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The aim of this research is to evaluate the mechanical properties and degradation behavior of the chitosan/hydroxyapatite/ferrite nanocomposites in the ringer solution. The initial materials, including chitosan and hydroxyapatite, were developed from shrimp shells and bovine cortical bone, respectively. Ferrite was also synthesized through wet-chemical method using FeCl 2 .4H 2 O and FeCl 3 .6H 2 O as precursors. The obtained results showed that the samples containing chitosan with a lesser deacetylation degree (73.5%) possess higher bending strength when compared to the samples with a higher deacetylation degree (82.5%). The samples with higher amounts of chitosan remain healthier and have a lesser weight loss percentage than the samples with more hydroxyapatite. The samples with the ratio of chitosan:hydroxyapatite (6:4) have displayed the smallest amount of degradation. Additionally, the samples with lower ratio of chitosan:hydroxyapatite (4:6) (the sample labeled as B) have demonstrated significantly higher fracture toughness (regarding to compression stress-strain curves) than other samples. Finally, it is concluded that chitosan/hydroxyapatite/ferrite nanocomposite with 6 g chitosan, 4 g hydroxyapatite, 0.5 g FeCl 2 .4H 2 O, and 1 g FeCl 3 .6H 2 O (the sample labeled as F) is selected as the optimal sample of this research, with regards to both of the mechanical properties and degradation behavior results. [ABSTRACT FROM AUTHOR]