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Technological progress in masonry structures has resulted in the creation of competitive solutions, which force the need for an ever deeper recognition of this type of structure. Masonry is a composite with heterogeneous strength properties. Therefore, the most appropriate way to accurately describe the behavior of the masonry structure under the influence of the working load are experimental research and their statistical and probabilistic analysis. This article presents a series of experimental tests carried out on real masonry structures. The results of the experiments were subjected to static evaluation, determining the most important parameter in the probabilistic analysis—the coefficient of variability of strength. The variability obtained in the experimental studies was used to determine the safety of the structure in the probabilistic method. Achieved values of coefficients of variation and safety coefficients proved to be satisfactory and adequate to the emerging technological progress in the production and embedding of masonry components. [ABSTRACT FROM AUTHOR]