Search

Your search keyword '"Zilin Ren"' showing total 2 results
Start Over Author "Zilin Ren" Journal marine drugs
2 results on '"Zilin Ren"'

1. Antibacterial Cyclic Tripeptides from Antarctica-Sponge-Derived Fungus Aspergillus insulicola HDN151418

Author

Chunxiao Sun, Ziping Zhang, Zilin Ren, Liu Yu, Huan Zhou, Yaxin Han, Mudassir Shah, Qian Che, Guojian Zhang, Dehai Li, and Tianjiao Zhu

Subjects
cyclic tripeptides, antibacterial, Antarctica sponge-derived fungus, Aspergillus insulicola, Biology (General), QH301-705.5
Abstract

Three new aspochracin-type cyclic tripeptides, sclerotiotides M–O (1–3), together with three known analogues, sclerotiotide L (4), sclerotiotide F (5), and sclerotiotide B (6), were obtained from the ethyl acetate extract of the fungus Aspergillus insulicola HDN151418, which was isolated from an unidentified Antarctica sponge. Spectroscopic and chemical approaches were used to elucidate their structures. The absolute configuration of the side chain in compound 4 was elucidated for the first time. Compounds 1 and 2 showed broad antimicrobial activity against a panel of pathogenic strains, including Bacillus cereus, Proteus species, Mycobacterium phlei, Bacillus subtilis, Vibrio parahemolyticus, Edwardsiella tarda, MRCNS, and MRSA, with MIC values ranging from 1.56 to 25.0 µM.

Published
2020
Full Text
View/download PDF

2. Antibacterial Cyclic Tripeptides from Antarctica-Sponge-Derived Fungus Aspergillus insulicola HDN151418

Author

Guojian Zhang, Chunxiao Sun, Zilin Ren, Huan Zhou, Ziping Zhang, Qian Che, Yaxin Han, Liu Yu, Mudassir Shah, Tianjiao Zhu, and Dehai Li

Subjects
Cell Survival, Protein Conformation, Stereochemistry, Bacillus cereus, Ethyl acetate, Antarctic Regions, Pharmaceutical Science, Antineoplastic Agents, Tripeptide, Bacillus subtilis, 01 natural sciences, Article, 03 medical and health sciences, chemistry.chemical_compound, cyclic tripeptides, antibacterial, Antarctica sponge-derived fungus, Aspergillus insulicola, Cell Line, Tumor, Drug Discovery, Animals, Humans, Aspergillus insulicola, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), lcsh:QH301-705.5, Mycobacterium phlei, 030304 developmental biology, 0303 health sciences, Bacteria, biology, 010405 organic chemistry, fungi, Edwardsiella tarda, Absolute configuration, Antarctica sponge-derived fungus, biology.organism_classification, Antimicrobial, Anti-Bacterial Agents, Porifera, 0104 chemical sciences, antibacterial, Aspergillus, chemistry, lcsh:Biology (General), cyclic tripeptides, Peptides
Abstract

Three new aspochracin-type cyclic tripeptides, sclerotiotides M–O (1–3), together with three known analogues, sclerotiotide L (4), sclerotiotide F (5), and sclerotiotide B (6), were obtained from the ethyl acetate extract of the fungus Aspergillus insulicola HDN151418, which was isolated from an unidentified Antarctica sponge. Spectroscopic and chemical approaches were used to elucidate their structures. The absolute configuration of the side chain in compound 4 was elucidated for the first time. Compounds 1 and 2 showed broad antimicrobial activity against a panel of pathogenic strains, including Bacillus cereus, Proteus species, Mycobacterium phlei, Bacillus subtilis, Vibrio parahemolyticus, Edwardsiella tarda, MRCNS, and MRSA, with MIC values ranging from 1.56 to 25.0 µM.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results