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7 results on '"D'Amore, Claudio"'

2. Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation

Author

Sepe, Valentina, primary, Di Leva, Francesco, additional, D'Amore, Claudio, additional, Festa, Carmen, additional, De Marino, Simona, additional, Renga, Barbara, additional, D'Auria, Maria, additional, Novellino, Ettore, additional, Limongelli, Vittorio, additional, D'Souza, Lisette, additional, Majik, Mahesh, additional, Zampella, Angela, additional, and Fiorucci, Stefano, additional

Published
2014
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4. Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis

Author

Mencarelli, Andrea, primary, D'Amore, Claudio, additional, Renga, Barbara, additional, Cipriani, Sabrina, additional, Carino, Adriana, additional, Sepe, Valentina, additional, Perissutti, Elisa, additional, D'Auria, Maria, additional, Zampella, Angela, additional, Distrutti, Eleonora, additional, and Fiorucci, Stefano, additional

Published
2013
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6. Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei

Author

Sepe, Valentina, primary, Ummarino, Raffaella, additional, D'Auria, Maria, additional, Taglialatela-Scafati, Orazio, additional, Marino, Simona, additional, D'Amore, Claudio, additional, Renga, Barbara, additional, Chini, Maria, additional, Bifulco, Giuseppe, additional, Nakao, Yoichi, additional, Fusetani, Nobuhiro, additional, Fiorucci, Stefano, additional, and Zampella, Angela, additional

Published
2012
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7. Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis.

Author

Mencarelli, Andrea, D'Amore, Claudio, Renga, Barbara, Cipriani, Sabrina, Carino, Adriana, Sepe, Valentina, Perissutti, Elisa, D'Auria, Maria Valeria, Zampella, Angela, Distrutti, Eleonora, and Fiorucci, Stefano

Abstract

In the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic inflammation and immune dysfunction in a mouse model of rheumatoid arthritis. Solomonsterol A was effective in protecting against the development of arthritis induced by injecting transgenic mice harboring a humanized PXR, with anti-collagen antibodies (CAIA) with beneficial effects on joint histopathology and local inflammatory response reducing the expression of inflammatory markers (TNFa, IFN? and IL-17 and chemokines MIP1a and RANTES) in draining lymph nodes. Solomonsterol A rescued mice from systemic inflammation were assessed by measuring arthritis score, CRP and cytokines in the blood. In summary, the present study provides a molecular basis for the regulation of systemic local and systemic immunity by PXR agonists. [ABSTRACT FROM AUTHOR]

Published
2014
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