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2 results on '"Bolin Hou"'

1. New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.

Author

Bolin Hou, Sushi Liu, Ruiyun Huo, Yueqian Li, Jinwei Ren, Wenzhao Wang, Tao Wei, Xuejun Jiang, Wenbing Yin, Hongwei Liu, Ling Liu, and Erwei Li

Subjects
mangrove-derived fungus, secondary metabolites, absolute configurations, bioactivity, Biology (General), QH301-705.5
Abstract

Two new diterpenoids, hypoxyterpoids A (1) and B (2), and four new isocoumarin derivatives, hypoxymarins A–D (4–7), together, with seven known metabolites (3 and 8–13) were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds 1, 2, 4, 5, and 7 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4′ in 6 and C-9 in 7 were determined by [Rh2(OCOCF3)4]-induced ECD spectra. Compound 1 showed moderate α-glucosidase inhibitory activities with IC50 values of 741.5 ± 2.83 μM. Compounds 6 and 11 exhibited DPPH scavenging activities with IC50 values of 15.36 ± 0.24 and 3.69 ± 0.07 μM, respectively.

Published
2021
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2. New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp

Author

Sushi Liu, Tao Wei, Wenzhao Wang, Yueqian Li, Wen-Bing Yin, Ling Liu, Xuejun Jiang, Ruiyun Huo, Erwei Li, Jinwei Ren, Hongwei Liu, and Bolin Hou

Subjects
Aquatic Organisms, Circular dichroism, Hypoxylon sp, Stereochemistry, QH301-705.5, Pharmaceutical Science, Fungus, 01 natural sciences, Article, Inhibitory Concentration 50, chemistry.chemical_compound, Drug Discovery, Ic50 values, Humans, Glycoside Hydrolase Inhibitors, Biology (General), Pharmacology, Toxicology and Pharmaceutics (miscellaneous), absolute configurations, Molecular Structure, biology, mangrove-derived fungus, 010405 organic chemistry, secondary metabolites, Fungi, Dpph scavenging, biology.organism_classification, Mass spectrometric, 0104 chemical sciences, Isocoumarin, 010404 medicinal & biomolecular chemistry, Isocoumarins, chemistry, bioactivity, Wetlands, Diterpenes
Abstract

Two new diterpenoids, hypoxyterpoids A (1) and B (2), and four new isocoumarin derivatives, hypoxymarins A–D (4–7), together, with seven known metabolites (3 and 8–13) were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds 1, 2, 4, 5, and 7 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4′ in 6 and C-9 in 7 were determined by [Rh2(OCOCF3)4]-induced ECD spectra. Compound 1 showed moderate α-glucosidase inhibitory activities with IC50 values of 741.5 ± 2.83 μM. Compounds 6 and 11 exhibited DPPH scavenging activities with IC50 values of 15.36 ± 0.24 and 3.69 ± 0.07 μM, respectively.

Published
2021

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