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2 results on '"Ferreira AGP"'

1. Correction to: Use of a NAT-based assay to improve the surveillance system and prevent transfusion-transmitted malaria in blood banks.

Author

Rocha D, de Melo GC, Carneiro JMH, Ribeiro M, Ribeiro S, de Godoy DT, Costa E, de Almeida ACG, de Andrade EF, de Moura Abrahim CM, Fraiji NA, Ferreira AGP, Monteiro WM, Brindeiro R, Tanuri A, de Lacerda MVG, and Alvarez P

Abstract

An amendment to this paper has been published and can be accessed via the original article.

Published
2020
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2. Use of a NAT-based assay to improve the surveillance system and prevent transfusion-transmitted malaria in blood banks.

Author

Rocha D, de Melo GC, Carneiro JMH, Ribeiro M, Ribeiro S, de Godoy DT, Costa E, de Almeida ACG, de Andrade EF, Abrahim CMM, Fraiji NA, Ferreira AGP, Monteiro WM, Brindeiro R, Tanuri A, de Lacerda MVG, and Alvarez P

Subjects
Adolescent, Adult, Blood Banks, Blood Transfusion, Brazil, Epidemiological Monitoring, Female, HIV Infections diagnosis, Hepatitis B diagnosis, Hepatitis C diagnosis, Humans, Malaria transmission, Male, Mass Screening instrumentation, Middle Aged, Pilot Projects, Plasmodium genetics, RNA, Protozoan analysis, RNA, Ribosomal, 18S analysis, Young Adult, Malaria prevention & control, Mass Screening methods, Nucleic Acid Amplification Techniques methods, Plasmodium isolation & purification, Population Surveillance methods
Abstract

Background: Malaria can be transmitted by blood transfusion through donations collected from asymptomatic donors. Transfusion-transmitted malaria (TTM) poses a great risk to blood services worldwide. A good screening tool for Plasmodium spp. detection in blood banks must have a high sensitivity for prevention of TTM. However, in Brazilian blood banks, screening for malaria still relies on microscopy., Methods: In Brazil, screening for human immunodeficiency virus type 1 (HIV), RNA/DNA for hepatitis C (HCV) and hepatitis B (HBV) viruses is mandatory for every blood donation and uses nucleic acid amplification testing (NAT). The aim of this study was to evaluate the inclusion of an assay for malaria to identify Plasmodium sp. from total nucleic acid (TNA; DNA/RNA) by targeting the 18S rRNA gene of the parasite., Results: Considering the limitations of microscopy and the wide availability of the Brazilian NAT platform in the screening of blood units for HIV, HCV, and HBV, a molecular diagnostic tool was validated for detection of Plasmodium sp. in blood banks; a pilot study showed that using this novel NAT assay could reduce the risk of TTM., Conclusion: The prototype HIV/HCV/HBV/malaria NAT assay was effective in detecting infected candidate donors and has good prospects to be applied in routine screening for preventing TTM.

Published
2020
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