8 results on '"Demar, Magalie"'
Search Results
2. Primaquine 30 mg/day versus 15 mg/day during 14 days for the prevention of Plasmodium vivax relapses in adults in French Guiana: a historical comparison
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Valdes, Audrey, Epelboin, Loic, Mosnier, Emilie, Walter, Gaelle, Vesin, Guillaume, Abboud, Philippe, Melzani, Alessia, Blanchet, Denis, Blaise, Nicaise, Nacher, Mathieu, Demar, Magalie, and Djossou, Felix
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- 2018
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3. Hyperparasitaemia during bouts of malaria in French Guiana
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Carme Bernard and Demar Magalie
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Malaria ,Plasmodium falciparum ,Plasmodium vivax ,Hyperparasitaemia ,Severe malaria ,French Guiana ,Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background High circulating parasite load is one of the WHO criteria for severe falciparum malaria. During a period of 11 years (2000–2010), the frequency of hyperparasitaemia (HP) (≥4% infected erythrocytes) during bouts of malaria due to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae in patients referred to Cayenne General Hospital (CGH) in French Guiana and the frequency of their admission to the Intensive Care Unit (ICU) were evaluated. Methods A mean of 1,150 malaria cases were referred to the Parasitology Laboratory of CGH each year over the last decade. During this period, malaria diagnostic (microscopy) and parasitaemia evaluation have remained unchanged: determination of the parasitized erythrocytes percentage with asexual forms on thin blood smears for all cases of parasitaemia exceeding 0.1%. Patients admitted to the ICU can be counted by origin of the request for malaria testing. All the data collected retrospectively were anonymized in a standardized case report form and in database. Results Between 2000 and 2010, 12,254 bouts of malaria were confirmed at the Parasitology Laboratory of CHG: P. vivax: 56.2%, P. falciparum: 39.5%, co-infection with both species: 3.4%, P. malariae: 0.9%. HP was observed in 262 cases, at a frequency of 4.9% for P. falciparum and only 0.041% for P. vivax, with no recorded cases for P. malariae. The need for intensive care was correlated with P. falciparum parasite load: 12.3% of cases for parasitaemia of 4-9%, 21.2% for parasitaemia 10-19%, 50% for parasitaemia 20-29% and 77.8% for parasitaemia ≥30% (n=9). The patient with the highest parasitaemia (75% infected erythrocytes with asexual form) presented a major concomitant lupus flare-up treated with corticoids. He survived without obvious sequelae. Conclusions In French Guiana during bouts of malaria, HP was observed at a frequency of ~ 5% for P. falciparum and two orders of magnitude less frequent for P. vivax. HP is a severity criterion for falciparum malaria in this endemic area. However, two of the patients with HP ≥30% were not admitted to the ICU and sequel-free cure in malaria patients with 75% parasitaemia is, therefore, possible.
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- 2013
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4. Primaquine 30 mg/day versus 15 mg/day during 14 days for the prevention of Plasmodium vivax relapses in adults in French Guiana: a historical comparison
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Epelboin, Loïc, Caumes, Eric, Guermonprez, Geraldine, Leturcq, France, Clarke, Peter, Nacher, Mathieu, Adenis, Antoine, Huber, Florence, Hallet, Edouard, Abboud, Philippe, Mosnier, Emilie, Bideau, Bastien, Marty, Christian, Lucarelli, Aude, Morel, Vanessa, Lacapère, François, Couppié, Pierre, Paraskevis, Dimitrios, Valdes, Audrey, Walter, Gaelle, Vesin, Guillaume, Melzani, Alessia, Blanchet, Denis, Blaise, Nicaise, Demar, Magalie Pierre, Djossou, Félix, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Fondation Maison des Champs, Biochimie et Génétique Moléculaire, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Croix-rouge française [Cayenne, Guyane Fraçaise], Service de Dermatologie, Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française], Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie, Université des Antilles (UA)-Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA), Service de Pharmacie [Cayenne, Guyane Française], Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine [Cayenne, Guyane] (COREVIH), and Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424
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Adult ,Male ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,Primaquine ,lcsh:RC955-962 ,030231 tropical medicine ,Plasmodium vivax ,Context (language use) ,World health ,lcsh:Infectious and parasitic diseases ,Antimalarials ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Internal medicine ,parasitic diseases ,Epidemiology ,Malaria, Vivax ,Secondary Prevention ,Humans ,Medicine ,lcsh:RC109-216 ,030212 general & internal medicine ,Relapse ,ComputingMilieux_MISCELLANEOUS ,Survival analysis ,Dose-Response Relationship, Drug ,biology ,business.industry ,Research ,Middle Aged ,biology.organism_classification ,medicine.disease ,Malaria ,French Guiana ,3. Good health ,Infectious Diseases ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Tropical medicine ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Parasitology ,business ,medicine.drug - Abstract
International audience; BACKGROUND:The preventive treatment of Plasmodium vivax relapse recommended by the World Health Organization is primaquine at a dose of 15 mg/day for 14 days, except for malaria cases from Asia and Oceania. Since 2006, CDC recommends the use of primaquine at 30 mg/day for 14 days. In France, all cases of malaria due to P. vivax are treated with 30 mg of primaquine. This systematically increased dosage needs to be evaluated according to epidemiological context. The aim of the study was to compare relapses after 14 days of primaquine at 15 or 30 mg/day.METHODS:All patients treated with primaquine after a vivax malaria episode in French Guiana, between 1 January, 2007 and 1 August, 2016, were studied. Based on the compulsory hospital pharmacy forms for primaquine delivery, adult patients who received 15 or 30 mg of primaquine during 14 days for hypnozoite eradication were included. The recommended dose was initially 15 mg and was changed to 30 mg in 2011. Vivax malaria recurrences within 2 months after primaquine treatment, and vivax malaria recurrences 2-6 months after primaquine in each treatment group were analysed using survival analysis at 2, 3 and 6 months.RESULTS:Out of 544 patients included, 283 received 15 mg/day and 261 received 30 mg/day of primaquine. At 2 and 3 months after primaquine treatment, the number of recurrences was 7 (2.5%) and 19 (7.3%), and 9 (3.4%) and 15 (5.3%), in the 15 and 30 mg groups (p = 0.51 respectively 0.35), respectively. Within 3 months, the median time to recurrence was 2.05 months in the 15 and 30 mg groups. At 6 months after primaquine treatment, the number of recurrences was 25 (8.8%) and 31 (11.9%) at 15 and 30 mg, respectively (p = 0.24). The median time to recurrence was 2.38 months at 15 mg/day and of 2.64 months at 30 mg/day.CONCLUSIONS:There were no significant differences between primaquine at 15 or 30 mg/day for 14 days in the prevention of P. vivax relapses at 2, 3 and 6 months after primaquine treatment in French Guiana
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- 2018
5. Prevalence of Plasmodium spp. in illegal gold miners in French Guiana in 2015: a hidden but critical malaria reservoir
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Douine, Maylis, primary, Musset, Lise, additional, Corlin, Florine, additional, Pelleau, Stéphane, additional, Pasquier, Jérémie, additional, Mutricy, Louise, additional, Adenis, Antoine, additional, Djossou, Felix, additional, Brousse, Paul, additional, Perotti, Frédérique, additional, Hiwat, Helene, additional, Vreden, Stephen, additional, Demar, Magalie, additional, and Nacher, Mathieu, additional
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- 2016
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6. Frequency and distribution of mixed Plasmodium falciparum-vivax infections in French Guiana between 2000 and 2008
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Ginouves, Marine, primary, Veron, Vincent, additional, Musset, Lise, additional, Legrand, Eric, additional, Stefani, Aurélia, additional, Prevot, Ghislaine, additional, Demar, Magalie, additional, Djossou, Félix, additional, Brousse, Paul, additional, Nacher, Mathieu, additional, and Carme, Bernard, additional
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- 2015
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7. The burden of Plasmodium vivax relapses in an Amerindian village in French Guiana
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Nacher, Mathieu, primary, Stefani, Aurelia, additional, Basurko, Celia, additional, Lemonnier, Delphine, additional, Djossou, Félix, additional, Demar, Magalie, additional, Elenga, Narcisse, additional, Brousse, Paul, additional, Ville, Muriel, additional, and Carme, Bernard, additional
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- 2013
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8. Primaquine 30 mg/day versus 15 mg/day during 14 days for the prevention of <italic>Plasmodium vivax</italic> relapses in adults in French Guiana: a historical comparison.
- Author
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Valdes, Audrey, Epelboin, Loic, Mosnier, Emilie, Walter, Gaelle, Vesin, Guillaume, Abboud, Philippe, Melzani, Alessia, Blanchet, Denis, Blaise, Nicaise, Nacher, Mathieu, Demar, Magalie, and Djossou, Felix
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PLASMODIUM vivax ,PREVENTIVE medicine ,PRIMAQUINE ,MALARIA treatment ,THERAPEUTICS - Abstract
Background: The preventive treatment of
Plasmodium vivax relapse recommended by the World Health Organization is primaquine at a dose of 15 mg/day for 14 days, except for malaria cases from Asia and Oceania. Since 2006, CDC recommends the use of primaquine at 30 mg/day for 14 days. In France, all cases of malaria due toP. vivax are treated with 30 mg of primaquine. This systematically increased dosage needs to be evaluated according to epidemiological context. The aim of the study was to compare relapses after 14 days of primaquine at 15 or 30 mg/day. Methods: All patients treated with primaquine after a vivax malaria episode in French Guiana, between 1 January, 2007 and 1 August, 2016, were studied. Based on the compulsory hospital pharmacy forms for primaquine delivery, adult patients who received 15 or 30 mg of primaquine during 14 days for hypnozoite eradication were included. The recommended dose was initially 15 mg and was changed to 30 mg in 2011. Vivax malaria recurrences within 2 months after primaquine treatment, and vivax malaria recurrences 2–6 months after primaquine in each treatment group were analysed using survival analysis at 2, 3 and 6 months. Results: Out of 544 patients included, 283 received 15 mg/day and 261 received 30 mg/day of primaquine. At 2 and 3 months after primaquine treatment, the number of recurrences was 7 (2.5%) and 19 (7.3%), and 9 (3.4%) and 15 (5.3%), in the 15 and 30 mg groups (p = 0.51 respectively 0.35), respectively. Within 3 months, the median time to recurrence was 2.05 months in the 15 and 30 mg groups. At 6 months after primaquine treatment, the number of recurrences was 25 (8.8%) and 31 (11.9%) at 15 and 30 mg, respectively (p = 0.24). The median time to recurrence was 2.38 months at 15 mg/day and of 2.64 months at 30 mg/day. Conclusions: There were no significant differences between primaquine at 15 or 30 mg/day for 14 days in the prevention ofP. vivax relapses at 2, 3 and 6 months after primaquine treatment in French Guiana. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
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