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Your search keyword '"Choi, Sung In"' showing total 33 results
Start Over Author "Choi, Sung In" Journal macromolecular research
33 results on '"Choi, Sung In"'

32. Alginate hydrogel embedding poly( D,L-lactide- co-glycolide) porous scaffold disks for cartilage tissue engineering.

Author

Choi, Sung-Wook, Moon, Seung-Kwan, Chu, Ji-Yeon, Lee, Hye-Won, Park, Tae-Joon, and Kim, Jung-Hyun

Abstract

Small poly( D,L-lactide- co-glycolide) scaffold disks (2 mm in diameter) with a bimodal porous structure of 237.5±34.2 μm for large pores and 9.2±3.9 μm for micropores were prepared by gas-forming and controlled-precipitation methods. Chondrocyte-seeded scaffold disks were dispersed in an alginate solution containing culture media. The dispersion was transferred into a Teflon mold with a specific shape, eventually forming an alginate hydrogel (approximately 1 cm in dimension) that contains cell/disk aggregates after crosslinking using CaCl. In vitro assessment of the alginate hydrogel showed significant increases in DNA and glycosaminoglycan content after 21 days, suggesting that chondrocyte still proliferated on the small scaffold disks in the alginate hydrogel despite its large dimensions. Moreover, in vivo immunohistochemical analysis of the alginate hydrogel demonstrated that chondrocytes secreted native extracellular matrix proteins ( e.g., collagen, proteoglycan). We believe that our approach of using alginate hydrogel containing cell/disk aggregates with a shape fitted to the target site could provide a versatile platform to engineer large and thick tissues and/or organs. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

Published
2012
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33. Core-shell poly( d,l-lactide- co-glycolide)/poly(ethyl 2-cyanoacrylate) microparticles with doxorubicin to reduce initial burst release.

Author

Lee, Sang-Hyuk, Baek, Hyon-Ho, Kim, Jung, and Choi, Sung-Wook

Abstract

Monodispersed microparticles with a poly( d,l-lactide-co-glycolide) (PLGA) core and a poly(ethyl 2-cyanoacrylate) (PE2CA) shell were prepared by Shirasu porous glass (SPG) membrane emulsification to reduce the initial burst release of doxorubicin (DOX). Solution mixtures with different weight ratios of PLGA polymer and E2CA monomer were permeated under pressure through an SPG membrane with 1.9 ώm pore size into a continuous water phase with sodium lauryl sulfate as a surfactant. Core-shell structured microparticles were formed by the mechanism of anionic interfacial polymerization of E2CA and precipitation of both polymers. The average diameter of the resulting microparticles with various PLGA:E2CA ratios ranged from 1.42 to 2.73 ώm. The morphology and core-shell structure of the microparticles were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The DOX release profiles revealed that the microparticles with an equivalent PLGA:E2CA weight ratio of 1:1 exhibited the optimal condition to reduce the initial burst of DOX. The initial release rate of DOX was dependent on the PLGA:E2CA ratio, and was minimized at a 1:1 ratio. [ABSTRACT FROM AUTHOR]

Published
2009
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