1. Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers
- Author
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Frauke Kracke, Anna Jemeljanova, Arne Strassburg, Hanne Petersen, Jannis Kuepper, Julia Wenners, and Joerg C. Tiller
- Subjects
chemistry.chemical_classification ,Biocide ,Polymers and Plastics ,Chemistry ,Cationic polymerization ,Bioengineering ,Polymer ,Antimicrobial ,Biomaterials ,chemistry.chemical_compound ,Minimum inhibitory concentration ,Amphiphile ,Materials Chemistry ,Polyquaternium ,Organic chemistry ,Selectivity ,Biotechnology - Abstract
Amphiphilic polycations are an alternative to biocides but also toxic to mammalian cells. Antimicrobially active hydrophilic polycations based on 1,4-dibromo-2-butene and tetramethyl-1,3-propanediamine named PBI are not hemotoxic for porcine red blood cells with a hemocytotoxicity (HC50) of more than 40,000 μg · mL(-1). They are quickly killing bacterial cells at their MIC (minimal inhibitory concentration). The highest found selectivity HC50 /MIC is more than 20,000 for S. epidermidis. Investigations on sequentially prepared PBIs with defined molecular weight Mn and tailored end groups revealed that there is a dependence of antimicrobial activity and selectivity on Mn and nature of the end groups.
- Published
- 2015
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