1. Bactericidal block copolymer micelles.
- Author
-
Vyhnalkova R, Eisenberg A, and van de Ven T
- Subjects
- Escherichia coli drug effects, Micelles, Microscopy, Electron, Scanning, Nanocapsules, Particle Size, Acrylates chemistry, Anti-Bacterial Agents pharmacology, Benzothiazoles pharmacology, Polystyrenes chemistry, Polyvinyls chemistry, Pyridines chemistry, Thiocyanates pharmacology, Triclosan pharmacology
- Abstract
Block copolymer micelles with bactericidal properties were designed to deactivate pathogens such as E. coli bacteria. The micelles of PS-b-PAA and PS-b-P4VP block copolymers were loaded with biocides TCMTB or TCN up to 20 or 30 wt.-%, depending on the type of antibacterial agent. Bacteria were exposed to loaded micelles and bacterial deactivation was evaluated. The micelles loaded with TCN are bactericidal; bacteria are killed in less than two minutes of exposure. The most likely interpretation of the data is that the biocide is transferred to the bacteria by repeated micelle/bacteria contacts, and not via the solution., (Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2011
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