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6 results on '"Lightwood, Daniel"'

2. The rapid generation of recombinant functional monoclonal antibodies from individual, antigenspecific bone marrow-derived plasma cells isolated using a novel fluorescence-based method

Author

Clargo, Alison M, Hudson, Ashley R, Ndlovu, Welcome, Wootton, Rebecca J, Cremin, Louise A, OʼDowd, Victoria L, Nowosad, Carla R, Starkie, Dale O, Shaw, Sophie P, Compson, Joanne E, White, Dominic P, MacKenzie, Brendon, Snowden, James R, Newnham, Laura E, Wright, Michael, Stephens, Paul E, Griffiths, Meryn R, Lawson, Alastair DG, and Lightwood, Daniel J

Published
2014

3. Antibody-mediated degradation of 4R-tau restores mitochondrial membrane polarization in human induced pluripotent stem cell-derived neurons with the MAPT10+16 mutation

Author

Starkie, Dale O., Arber, Charles, Baker, Terry, Lightwood, Daniel J., and Wray, Selina

Abstract

ABSTRACTMicrotubule-associated protein tau is inextricably linked to a group of clinically diverse neurodegenerative diseases termed tauopathies. The ratio balance of the major tau splicing isoform groups (3 R- and 4 R-tau) is critical in maintaining healthy neurons. An imbalance causing excess 4 R tau is associated with diseases such as progressive supranuclear palsy and frontotemporal dementia. The mechanisms by which increased 4 R results in neuronal dysfunction and neurodegeneration are not fully understood, and progress has been limited partly by a lack of suitable tools to investigate tau isoform imbalance. This work generated novel 3 R- and 4 R-specific antibody tools and 4 R-tau degrading intracellular antibody fragment “degrabodies”. These were used to probe the molecular mechanisms of excess 4 R-tau in disease-mutant induced pluripotent stem cell-derived neurons. For the first time, we demonstrate a causative link between excess 4 R-tau and mitochondrial membrane hyperpolarization with wide-ranging potential for elucidating novel therapeutic approaches to treat neurodegenerative disease.

Published
2024
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4. Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration

Author

Smith, Bryan, primary, Kiessling, Andrea, additional, Lledo-Garcia, Rocio, additional, Dixon, Kate L., additional, Christodoulou, Louis, additional, Catley, Matthew C., additional, Atherfold, Paul, additional, D’Hooghe, Lena E., additional, Finney, Helene, additional, Greenslade, Kevin, additional, Hailu, Hanna, additional, Kevorkian, Lara, additional, Lightwood, Daniel, additional, Meier, Christoph, additional, Munro, Rebecca, additional, Qureshi, Omar, additional, Sarkar, Kaushik, additional, Shaw, Sophie P., additional, Tewari, Roohi, additional, Turner, Alison, additional, Tyson, Kerry, additional, West, Shauna, additional, Shaw, Stevan, additional, and Brennan, Frank R., additional

Published
2018
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5. The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method

Author

Clargo, Alison M, primary, Hudson, Ashley R, additional, Ndlovu, Welcome, additional, Wootton, Rebecca J, additional, Cremin, Louise A, additional, O'Dowd, Victoria L, additional, Nowosad, Carla R, additional, Starkie, Dale O, additional, Shaw, Sophie P, additional, Compson, Joanne E, additional, White, Dominic P, additional, MacKenzie, Brendon, additional, Snowden, James R, additional, Newnham, Laura E, additional, Wright, Michael, additional, Stephens, Paul E, additional, Griffiths, Meryn R, additional, Lawson, Alastair DG, additional, and Lightwood, Daniel J, additional

Published
2013
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6. The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method.

Author

Clargo, Alison M., Hudson, Ashley R., Ndlovu, Welcome, Wootton, Rebecca J., Cremin, Louise A., O'Dowd, Victoria L., Nowosad, Carla, Starkie, Dale O., Shaw, Sophie P., Compson, Joanne E., White, Dominic P., MacKenzie, Brendon, Snowden, James, Newnham, Laura, Wright, Michael, Stephens, Paul, Griffiths, Meryn, Lawson, Alastair D. G., and Lightwood, Daniel J.

Published
2014
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