1. Halloysite nanotubes as a carrier of cornelian cherry (Cornus mas L.) bioactives.
- Author
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Blagojević, Bojana, Četojević-Simin, Dragana, Parisi, Filippo, Lazzara, Giuseppe, and Popović, Boris M.
- Subjects
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HALLOYSITE , *FRUIT extracts , *CHERRIES , *LOCAL delivery services , *IRIDOIDS , *CELL growth , *ANTHOCYANINS - Abstract
Cornelian cherry fruit extract rich in anthocyanins and iridoids was encapsulated in the halloysite nanotubes in order to obtain a stable nanoscale system for better delivery and prolonged release of bioactive constituents. The cyclic vacuum technique was used for halloysite nanotubes-cornelian cherry composite preparation and the loading of 8.5 wt% was achieved. Pure cornelian cherry extract exhibited antiproliferative effect on HT-29, MCF7, and MRC-5 cells, pristine halloysite nanotubes affected the growth of MCF7 cells, while halloysite nanotubes-cornelian cherry composites demonstrated proliferative activity in all tested cells. The sustained release of anthocyanins was achieved by this encapsulation strategy. Additional implementation of halloysite nanotubes-cornelian cherry into yogurt prolonged the release of iridoid molecules. Obtained results indicate that halloysite nanoclay is a suitable nanocarrier for cornelian cherry constituents that can be utilized in food and pharmaceutical industries. Image 1 • Halloysite nanotubes were efficiently loaded with cornelian cherry bioactives. • Halloysite nanotubes-cornelian cherry composites promoted cell growth. • Halloysite nanotubes provided sustained release of cornelian cherry anthocyanins. • Addition to yogurt prolonged release of cornelian cherry iridoids. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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