7 results on '"Sehested, M"'
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2. Four out of six human NYH small cell lung cancer cell lines resistant to ICRF-187 have either R162Q or Y165S functional mutations in the Walker ATP binding site of topoisomerase II alpha
3. Targeting the cell kill of etoposide to brain metastases. A method for prophylactic cranial chemotherapy (PCC) in small cell lung cancer
4. 696 Immunohistochemical detection of topoisomerase II α (Topollα) P-glycoprotein (Pgp), and multidrug resistance protein (MRP) in non small cell lung cancer (NSCLC) and in small cell lung cancer (SCLC) before and after treatment with topoll directed drugs
5. 89 ICRF-187 enables dose escalation of the topoisomerase II poisons, etoposide and teniposide. An in vivo model targeting high-dose chemotherapy to CNS tumors
6. 558 Sequential coexpression of all 3 multidrug resistance (MDR) phenotypes in a single human small cell lung cancer (SCLC) cell line exposed to etoposide, H69VP. An illustration of the complex progression of drug resistance
7. 117 Characterization of high and low level resistance to topoisomerase I poisons in small cell lung cancer cells resistant to camptothecin and topotecan
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