1. The corrected donor age for hepatitis C virus–infected liver transplant recipients
- Author
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Dirchwolf, Melisa, Dodge, Jennifer L, Gralla, Jane, Bambha, Kiran M, Nydam, Trevor, Hung, Kenneth W, Rosen, Hugo R, Feng, Sandy, Terrault, Norah A, and Biggins, Scott W
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Organ Transplantation ,Chronic Liver Disease and Cirrhosis ,Hepatitis - C ,Digestive Diseases ,Emerging Infectious Diseases ,Infectious Diseases ,Liver Disease ,Hepatitis ,Transplantation ,Good Health and Well Being ,Adult ,Age Factors ,Decision Support Techniques ,Donor Selection ,End Stage Liver Disease ,Female ,Graft Survival ,Hepatitis C ,Humans ,Likelihood Functions ,Liver Transplantation ,Male ,Middle Aged ,Multivariate Analysis ,Predictive Value of Tests ,Proportional Hazards Models ,Reproducibility of Results ,Risk Assessment ,Risk Factors ,Time Factors ,Tissue Donors ,Treatment Outcome ,United States ,Surgery ,Clinical sciences - Abstract
Donor age has become the dominant donor factor used to predict graft failure (GF) after liver transplantation (LT) in hepatitis C virus (HCV) recipients. The purpose of this study was to develop and validate a model of corrected donor age (CDA) for HCV LT recipients that transforms the risk of other donor factors into the scale of donor age. We analyzed all first LT recipients with HCV in the United Network for Organ Sharing (UNOS) registry from January 1998 to December 2007 (development cohort, n = 14,538) and January 2008 to December 2011 (validation cohort, n = 7502) using Cox regression, excluding early GF ( 8 hours and -1 year/hour
- Published
- 2015