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Lymphocytes phospholipid membranes fatty acid spectrum was studied in patients with coronary heart disease. The study involved 77 patients aged 45 to 72 years. Significant decrease of the oleic fatty acid relative content was determined, which violates the lymphocytes membranes structure and possibly negatively affect their functioning. The relative content of arachidonic, palmitic and stearic saturated fatty acids composition of lymphocytes lipids increased. The result indicate that in patients with coronary heart disease increasing polyunsaturated fatty acids elongation in lymphocytes. These changes in the lipid blood, lymphocytes state can explain the observed increase in lymphocytes functional activity.

The results of the survey 16 children with acute lymphoblastic leukemia, in which the resulting protocol chemotherapy using doxorubicin developed toxic anthracycline-induced cardiomyopathy. The control group was 20 healthy children of similar age studied. Distribution of research groups included age status and cumulative dose of doxorubicin. Studies of the cardiovascular system in children with acute leukemia was conducted before and at the end of each protocol chemotherapy. It is noted that the complaints of the cardiovascular system as palpitations and disruptions in the heart, cardialgia, autonomic crises occurred at the end of the first phase I protocol chemotherapy. Severity of complaints prevalent in patients with higher cumulative dose of doxorubicin. Noted a decrease in left ventricular contractile capacity and the development of myocardial ischemia in patients with acute leukemia at the end of the first phase II protocol. The increase pro-brain natriuretic peptide in all patients with acute lymphoblastic leukemia at the end of the first phase I protocols that can be considered as an early diagnostic marker of myocardial injury in these patients.

Present article is devoted to the study of the clinic features of ischemic heart desease associated with acid peptic disease. It was shown the more evident increase of myocardial infarction risk in associated pathology patients. Such results have to be caused by the special risk factor. As such factor we desided to study the hyperhomosysteinemia. During research there were discovered that the lowest vitamin B12 serum level and the highest homocysteine serum level have been registrated in associated pathology (ischemic heart disease and acid peptic disease according to long-term proton pump inhibitor use) patients. It was shown evident correlation between that changes and dyslipidemia.

Special features of silent myocardial ischemia course were examined depending on the presence of cardiovascular risk factors. Data on interdependence of risk factors presence and figures of holter monitoring of electrocardiography was received. It was ascertained that for the patients with silent myocardial ischemia with such risk factors occurrence of complicated course of ischemic heart disease, such as arterial hypertension, diabetes and hyperlipidemia, the following indicators are typical: higher average daily indicators of ischemic episodes per day, higher aggregate daily duration of ST-segment depression, higher aggregate amplitude of ST-segment depression, higher average duration of one ischemic episode, compared to the persons without risk factors. Probability of antinociceptional system activation processes influence on the risk of accrual of acute coronary syndrome was proved.

354 patients with chronic heart failure (CHF) of ischemic origin with systolic left ventricular dysfunction (SLVD) and 227 patients with preserved left ventricular ejection fraction (PLVEF) were examined. This study was aimed at the studying of comparative aspect of survival of patients with CHF and SLVD and with PLVEF for 48 months of observation, and the studying of nonsurvival predictors. Survival of patients with PLVEF is significantly better compared with survival of patients with SLVD for 48 months (66% and 42% respectively). The most informative predictors of 48 month in patients with SLVD were: uric acid level (OR = 3,17), end-systolic volume (OR = 2,71), hemoglobin level (OR = 2,64), creatinine level (OR = 2,36), end-dyastolic volume (OR = 2,49), index of end-systolic volume (OR = 2,44). The most informative predictors in patients PLVEF were: cholesterol level (OR = 2,14) and distance of 6-minute walk (OR = 2,11).

581 patients with chronic heart failure (CHF) of ischemic origin with systolic left ventricular dysfunction (SLVD) and preserved left ventricular ejection fraction (PLVEF) were examined. The aim of the study was to investigate the comparative aspect of laboratory examination of patients with chronic heart failure of ischemic origin with left ventricular systolic dysfunction and patients with heart failure and preserved left ventricular ejection fraction. The study found no differences in the groups on the basic parameters: the number of white blood cells, hemoglobin concentration, red blood cell count, platelet count, the number of potassium and sodium ions. At the same time, patients with CHF and left ventricular systolic dysfunction characterized by the presence of a moderate decline in glomerular filtration rate, including more frequent patients with lymphocytopenia, hypoholesteremia, hyperuricemia. For patients with chronic heart failure and preserved left ventricular ejection fraction the following characteristics have been characterized: normal or increased glomerular filtration rate, hypercholesterolemia.

The results of the study parameters lipid profile and C-reactive protein (C-RP) in patients with angina pectoris after applying meksykoru. Combined treatment with meksykoru to correct the atherogenic lipid profile and CRP helped reduce content CRP, total cholesterol, low-density lipoprotein cholesterol, triglycerides, factor aterohenosti and raise HDL cholesterol.

The results suggest that addition of pioglitazone in a complex treatment therapy of patients with ischemic heart disease on background of metabolic syndrome was not associated with an increased ischemic heart disease (IHD) risk and improved the clinical course of IHD, increased effectiveness of standard therapy for patients with IHD and metabolic syndrome.

The aim of this investigation was to study the frequency and duration of silent myocardial ischemnia (SMI) and to evaluate its relationship with the duration of rheumatoid arthritis (RA) and hyperhomocysteinemia. 63 patients with rheumatoid arthritis were observed, during this study we investigated homocysteine blood level, markers of an inflammation and episodes of SMI using daily (cholter) ECG monitoring. It was often recorded "silent" myocardial ischemia in patients with the RA, which was associated with high activity of inflammatory process (high C-reactive protein, the disease activity score, HAQ, number of swollen and painful joints) and hyperhomocysteinemia, whereas disease duration was less important in formation of SMI.

The authors presents in the article information on influence of endothelial dysfunction and level of blood leukocytes with clinical course of stable angina pectoris in patients with ischemic heart disease (IHD). 104 male patients aged from 36 to 69 (on average 54.9+/-2.1 years) with IHD and stage I-III stable angina pectoris have been observed. The level of leukocytes, ECG daily monitoring, endotelial function with the help of Celermaera-Sorensena test and plasma concentration of endothelin I have been studied in patients. It was established that there is no significant different (P>0.05) in the level of leukocytes between health persons and patients with IHD independently of functional class of angina pectoris. Patients with IHD had higher level of endothelin I in their blood serum than those in a control group. Patients with IHD have a complicated endothelial-non-dependent vasodilation and an increased thickness of the complex intima-media, there is a negative correlation bond between these characteristics. Patients III functional class of angina pectoris has also reliably decreased endothelial-dependent vasodilation by 37%. Frequency of ventricular extrasystoles in patients with IHD and endothelial dysfunction increases by 12 times.

The study of 37 patients with chronic obstructive bronchitis combined with coronary heart disease during exacerbation of these diseases has revealed blood microcirculation disorders of its vascular, intra- and extravascular parts. It's also showed an increase in specific quantity of blood serum medium- and high-molecular surface-active substances, in mean corpuscular volume and sorptive activity of erythrocytes, nitrite/nitrate contents, and medium-molecular peptides. It has been revealed at the same time cytogenetic derangements of lymphocytes, low monocyte phagocytic activity. There were only 25.7% of the observed patients, who presented with some normal indices by the time of clinical remission of the diseases.

Systemic circulation compromise in patients with cardiac insufficiency results in disturbances of functional state of pancreas. The Willebrand's Factor takes a definite role in this pathological process. The usage of Peridopril 4 mg daily during the treatment decreases significantly Willebrand's Factor activity and normalizes function of the pancreas.

Effect of Simvastatin on lipid metabolism, platelet aggregation properties and vasoactive eicosanoids content in blood plasma of patients with hypercholesterinemia (dislipoproteinemia II-A, II-B, and IV type) has been studied by the authors. 49 patients with coronary heart disease, stable angina of effort, II-III functional classes by NYHA have been observed. 57.1% of the patients had normal cholesterol levels (less 200 mg/dl) at the end of the therapy, 37.6% of the patients had reached border levels of cholesterol in their blood serum (200 to 240 mg/dl). It was established that beneficial effect of Simvastatin is associated not only with its hypolipidemic activity but also with pleothropic effect of the medication. Positive shifts in morphofunctional state and thrombocytes aggregation indexes have been noted in the process of the treatment.

The article presents a current view on the pathophysiology of acute coronary syndrome with and without ST elevation. Up-to-date thrombolytic agents and heparins are illustrated in the article. Current principles and thrombolytic therapy methods of an acute coronary syndrome without ST elevation are given in the article.

The authors have studied effects of the course treatment with doxasosine, a selective alpha 1-adrenoblocker, on lipid and immunological indices in 46 male subjects with ischemic heart disease presenting with functional class I-III exertional angina. A significant improvement in indices for lipid metabolism has been shown together with absence of negative influence on parameters characterizing immunologic vigour with no worsening of manifestations of T-cellular immune deficiency. In hypercholesterinemia-free middle-aged subjects, posttreatment alterations in the peripheral blood can be regarded as a result of a positive effect on immunological reactivity.

The paper focuses on the membrane lipid complex status and lymphocyte metabolic activity in IHD patients to elaborate new approaches toward treatment and prevention of immune disorders in the above pathology. The study was made in blood specimens from 53 coronary patients presenting with progressive unstable angina. The diagnosis was made on the basis of a complex clinical-and-laboratory and electrocardiographic evaluation. The composition of the lymphocyte membrane lipid complex and blood serum was studied with the aid of the gas chromatography techniques. Three variants were identified of change in the lipid composition of lymphocyte membranes in IHD patients having undergone the above evaluation. We consider it expediant to use criteria for the state of lymphocyte membranes in IHD patients in order that we might properly deal with issues concerning diagnosis, prognosis and selection of optimum pathogenetic therapy of the medical condition in question.

Results are submitted of investigations designed to study effects of prazosine on the clinical course, immune and lipid spectrum of blood plasma in IHD patients with functional class I-II middle-aged and elderly-onset exertional angina. Efficiency of prazosine monotherapy was recordable in all FC I-II effort angina patients 30 to 50 years old, which fact was manifested by a decline in the number of angina attacks over the 24-hour period, number and duration of both pain and symptom-free myocardial ischemia, improvement in physical load tolerance. Also recordable in all patients was a positive effect of the drug on blood plasma lipid spectrum and certain immunological indices.

Coagulating activity was studied of the arterial and venous blood platelet-rich and platelet-poor plasma in 16 patients with unstable angina (UA). An unusual activation of the hemostatic potential was recordable in the venous and arterial beds, as per changes in the general index of thrombophilia, which fact, along with the presence of FDR and fibrin-monomer complexes, can be regarded as signs of disseminated intravascular coagulation which can cause thrombogenic complications in UA patients. Changes in the system of hemostasis in the above patients (as evidenced by the index of thrombophilia) might suggest the prethrombotic state. The results obtained showed that platelets had an important role in the formation of the hemostatic potential both in the venous and arterial blood in UA.

Efficiency has been studied of a combined treatment involving the use of mineral baths with the brine of bischofite Poltavsky. Bischofite is a natural efficacious preparation, low-cost, it is easily obtainable. The Poltava lands abound in bischofite deposits.

Changes were studied in the blood plasma content of trace elements (iron, zinc, manganese, copper and zinc) before and after a 20-day course of treatment in patients with IHD, stable angina, who were given, apart from antianginal therapy, eunicap M having in its composition trace elements (iron, manganese, cuprum, and other trace elements). It has been ascertained that IHD is accompanied by changes in the blood plasma content of trace elements. Combination of eunicap M with antianginal therapy promotes the tendency toward normalization of iron and cuprum metabolism; there was no significant change in the content of zinc and manganese, which fact may be related to a deficient content of manganese in the given drug preparation or a greater demand for them in patients with atherosclerosis.

Different variants of the prostanoid system response under paroxysms of tachycardia in patients with ischemic heart disease presenting with preexcitation syndrome are believed to be not only a manifestation of etiological and pathogenetic differences--they also reflect particular features of the state of the neurohumoral control on the whole in the nosological forms studied.

Effects were studied of diltiazem on parameters characterizing cardiohemodynamics, peripheral bloodflow, condition of atrial natriuretic peptide (ANUP), of cyclic nucleotides (cGMP), the renin-angiotensin system in patients with various manifestations of stenocardia. An inhibitory action of diltiazem on ANUP and cGMP secretion in a VEM-test was recordable but changes were not significant at the height of the drug action in rest. Improvement in myocardial contractility after the course treatment with the drug was accompanied by reduction in blood plasma levels of ANUP and cGMP. It is suggested that changes in ANUP concentration might be traced to improvement in the anginal course and to the drug effects such as lowering of myocardial oxygen demand, of pre- and afterload, improvement in the indices for myocardial contractility.

The data obtained by the authors suggest that lipanor may correct those lipid metabolic disturbances that are most pronounced in each individual case. Moreover, the above drug is capable of lowering substantially the level of total blood cholesterol and atherogenic fractions of lipoproteins as early as at day 14 after its intake. Being associated with minimum adverse effects, and intended to be taken on a once-daily schedule, the drug will, we believe, come in wide use.

With the purpose of assessing the influence that platelet morphofunctional state may have on the degree of destabilization in patients with different forms of unstable angina we examined 198 patients using stress tests, Holter ECG monitoring, studying activation of thrombocytes with the aid of a luminescent-microscopy technique, and performing an analysis of aggregation. Important differences have been revealed in the studied parameters in those patients presenting with freshly detected and progressive stenocardia and with a developing, despite of the treatments administered, myocardial infarction, that might be caused by abnormal shifts in the thrombocyte intact/activated forms ratio.

In a study of 114 patients with ischemic heart disease (IHD) a relatedness has been found out of frequency and duration of "silent" ischemia of the myocardium to the degree of severity of atherosclerotic affection of the vascular bed and aggravation of IHD clinical symptomatology, with the activity of the opioid system tending to decline, catecholamines concentration being on the increase. It is beta-endorphin and leucine-enkephalin that have an important part to play in the regulation of algesthesia in IHD patients, the plasma content of which substances gets appreciably higher in exercise-induced painless ischemia. A change in the opioid-adrenosympathetic equilibrium is considered to be related to features of IHD clinical course. It is suggested that maintenance of the above two systems dynamic equilibrium might be of adaptive, antistressor character.

A total of 156 patients with ischemic heart disease were examined under conditions of preoperative stress in a multiple-modality study performed with the aid of such techniques as echocardiography involving calculation of the myocardial mass index, coronaroventriculography, measurements of the adrenocorticotrophic hormone, hydrocortisone, somatotrophic hormone, triiodothyronine and thyroxin in the blood from the coronary sinus and aorta. A conclusion has been reached that emotional strain influences myocardial hypertrophy. A possible significance of the studied hormonal indices is shown together with features thereof in IHD patients presenting with different degrees of left ventricular hypertrophy.

Measured in 119 patients with chronic heart disease (exercise-induced angina in 62, cardiosclerosis in 57 cases) presenting with arrhythmias (extrasystolic arrhythmia, permanent form cardiac fibrillation, association of cardiac fibrillation with ventricular arrhythmia, with n = 58, 38, 23 respectively) were blood levels of thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxin (T4) using immunoradiometric assay. In extrasystolic arrhythmia, permanent form cardiac fibrillation, there were no deviations from the norm in the basal TSH blood levels, reduction in (T3) as well as augmentation of (T4) in cardiac fibrillation. With permanent form cardiac fibrillation associated with ventricular arrhythmia the TSH blood level got decreased, the (T3) and (T4) content undergoing no changes The posttreatment blood content of (T3) tended to augment in extrasystolic arrhythmia.

Overall ninety-six ChIHD patients presenting with disturbances of cardiac rhythm were evaluated by radioimmunologic technique for blood content of somatotrophic hormone (STH) and hydrocortisone. In ChIHD patients presenting with extrasystolic arrhythmia, basal STH blood levels tend towards getting decreased, those of hydrocortisone increased. On dispelling extrasystole, blood STH content gets increased, with hydrocortisone levels remaining elevated. Recordable in ChIHD with invariable form of cardiac fibrillation are unchanged STH basal levels and increased content of hydrocortisone in blood.

Effects were studied of Na+ ions on parameters characterizing phases of blood coagulation as was the state of the fibrinolysis system in 22 patients with ischemic heart disease presenting with hypercoagulation, using a laboratory model of a new apparatus "Koaguloskop TS", its prototype being electrocoagulograph. It has been proved for the first time that Na+ ions are involved in the reduction of the blood coagulative potential and clot density, increase in the power of the anticoagulation system, quick activation of the processes of fibrinolysis and efficient lysis of the clot. A real idea of degree of hemostasis destruction permit obtaining values reflecting the result of the whole blood physical and chemical reaction of coagulation (or fibrinolysis) as a quantity of the substance produced and its density in each phase.

Overall eighty four patients suffering from ischemic heart disease (IHD) and hypertensive disease (HD) were evaluated for levels of glycated hemoglobin (gly-Hb) in blood and effects of glycating on blood serum lipid spectrum. Elevated gly-Hb levels were recordable in 51.1% of the patients. Such patients showed significant augmentation of content of total lipids, triglycerides, total cholesterin, Burstein's test, rise in the coefficient of atherogenicity as compared to those subjects having normal gly-Hb level. Positive correlation was established between gly-Hb, levels of total lipids, triglycerides. Given in this paper are the following recommendations for IHD and HD patients presenting with increased gly-Hb level: restricted consumption of easily assimilable carbohydrates, diet N 9, no diabetogenic drugs.

Low-temperature spectra were measured of blood plasma fluorescence and phosphorescence in patients with ischemic heart disease. It has been shown that structure of radiation spectra depends upon severity of illness and use of ultra-violet radiation of blood as a therapeutic procedure. It is suggested that radiational processes in blood plasma might be caused by luminescence of proteins, lipoproteins and radicals of blood plasma. A conclusion is reached to the effect that measurement of spectra of luminescence, phosphorescence under low temperatures of blood plasma is of great importance for understanding mechanisms of pathological processes and efficiency of the treatment options employed.

Derangement in freeradical processes (FRP) and lipid metabolism is known to occur in ischemic heart disease. Since autoimmune component appear to play an important role in the pathogenesis of IHD, the contributers to the article studied the state of freeradical processes in IHD patients during development of autosensibilization. A total of 42 patients with unstable angina and 8 essentially healthy subjects were examined. The blood level of FRP, antioxidant protection were determined using chemiluminometry technique. The blood serum content of free cholesterol and phospholipid fatty acid composition were evaluated by gas-liquid chromatography, the T- and B-lymphocyte functional status by fluorescent probing with acridine orange. The level of autoantibodies was determined as recommended by Boiden. The lymphocyte circulating population functional activity was found to be related to the state of FRP, antioxidant protection and the blood serum lipidic complex composition.

A study was made as well as a comparison of values of the cholesterol (Chs) lipid fractions concentrations, and of those of the lipid peroxidation processes activity (LPP) and the gluthathione antioxidant system (AOS) status in male subjects aged from 45 to 59 years, healthy individuals and patients with stable angina pectoris and myocardial infarction (micro- and macrofocal) during cicatrizing stage (health resort rehabilitation stage). In patients with various forms of IHD total cholesterol is raised as are atherogenic lipoproteins, and atherogenicity index, intensification being noted of LPO along with a considerable decrease in functional potencies of AOS. Similar pattern of changes of LPO and AOS in patients with stable angina pectoris and myocardial infarction (MI) during cicatrization stage certainly warrants correction of these systems not only in acute phase of MI but at the stage of rehabilitation as well.

The article deals with electro-kinetic potential of cellular nucleus considered as an indicator of unspecific reactivity and presents some data on molecular and cellular mechanisms of adreno- and muscarino-receptive interactions, such as adrenalin, noradrenaline and DOPA blood levels, lipid peroxidation, erythrocyte resistance to peroxidation. The attempt is made to comprehend directions and trends of aforementioned processes in patients with stable and unstable stenocardia as well as in myocardial infarction with regard to sex and influence of central M-cholinoblockader amizyl. The drug provides adaptive effect, corrects affected adreno-reception, protects biomembranes from lesion, promotes their "fluidity" and reduces rigidity.

Renin-angiotensin-aldosterone system (RAAS) in patients with rheumatic valve defects clearly tends to activation which in its turn aggravate chronic heart failure (CHF). Plasma renin activity in CHF depends on the cause of the latter, humoral changes in rheumatic heart disease being the most considerable. At the same time activated RAAS was characteristic of patients with rhythm disorders. All this evidence an important role of morphological changes and affected intracardiac haemodynamics in development of humoral vicious circle.

A study of 126 patients with stenocardia receiving antianginal treatment was carried out with purpose of evaluating the effect of plasmapheresis on the clinical course of the disease, functional activity of thrombocytes, eicosanoids and lipid metabolism. It was shown that plasmapheresis improves the clinical condition of patients with ischemic heart disease, increases the tolerance to physical loads in patients with stenocardia. The mechanism of action of plasmapheresis is related to improvement of the lipid metabolism, system of eicosanoids, and thrombocytic link of hemostasis.

Evaluation of the concentration of atrial natriuretic peptide, angiotensin P, renin activity in the blood of the coronary sinus and aorta in 18 patients with IHD and hypertrophy of the left ventricle during development of induced ischemia revealed that in left ventricular hypertrophy secretion of atrial natriuretic peptide by the myocardium is reduced. The level of this reduction depends on the kind of hypertrophy. Dilatation of the left ventricle cavity furthers exhaustion of the secretory function of the ischemic myocardium.

The effect of the thymus polypeptide factor-thymidin on the lipid spectrum of the blood, thymic factor content in the blood and clinical course of the disease were studied in 156 patients with exertion stenocardia (II-IV functional class). Results indicate that patients with exertion stenocardia show with advance of the disease a reduction of the blood thymic factor and 85.6% develop hyperlipidemia. Complex treatment with inclusion of thymalin resulted in an increase of the thymic factor, normalization of the lipid metabolism increase of the contractile function of the myocardium and, thus, increases the treatment efficacy.

A study is presented of the effect of reinfusions of ultraviolet-irradiated autologous blood on the number of lymphocytes, titer of circulating immune complexes and theophylline-sensitive cells, number of immunoglobulins A, G and M, number and form of erythrocytes in 30 patients with stable and progressive exertion stenocardia. Thirty control patients were treated with nitrates, calcium antagonists and acetylsalicylic acid. It was established that in patients with stenocardia quantum hemotherapy produces an immunocorrective action reduces the titer of circulating immune complexes, the content of T-lymphocytes, the number of immunoglobulins A and G, normalizes the morphological and functional activity of erythrocytes. Use of this method in the treatment of ischemic heart disease is pathogenetically justified and prevents development of myocardial infarction.

The efficacy of physiotherapeutic methods in association with preliminary aspirin intakes was examined in 276 patients with ischemic heart disease. Results indicate that the main clinicofunctional and laboratory indices showed a positive dynamics. The above treatment is considered perspective in the restorative treatment and secondary prophylaxis of patients with ischemic heart disease.