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Start Over Author "Rehab Ali Hussein" Journal life sciences
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1. Phycocyanin stimulates ulcerative colitis healing via selective activation of cannabinoid receptor-2, intestinal mucosal healing, Treg accumulation, and p38MAPK/MK2 signaling inhibition

Author

Walaa H. El-Maadawy, Ehab Hafiz, Hend Okasha, Noha A. Osman, Gamila H. Ali, and Rehab Ali Hussein

Subjects
Lipopolysaccharides, Colon, MAP Kinase Signaling System, Dextran Sulfate, Anti-Inflammatory Agents, Phycocyanin, General Medicine, Colitis, T-Lymphocytes, Regulatory, General Biochemistry, Genetics and Molecular Biology, Molecular Docking Simulation, Disease Models, Animal, Mice, Animals, Humans, Colitis, Ulcerative, General Pharmacology, Toxicology and Pharmaceutics, Caco-2 Cells, Receptors, Cannabinoid
Abstract

Ulcerative colitis (UC) is a chronic inflammatory condition that until this date, lacks curative treatments. Previously, synthetic selective CB2 receptor (CB2R) agonists demonstrated effective preclinical anti-inflammatory activities in UC. Phycocyanin (PC), photosynthetic assistant protein isolated from Microcystis aeruginosa Kützing blue green algae, has multiple pharmacological effects, however, it's effect against UC remains unexplored. Our study aimed at investigating the therapeutic effectiveness of PC against UC, and correlating its mechanisms with CB2R agonistic activities. In silico; PC showed structural similarity with endocannabinoid receptors' ligand "Δ

Published
2022

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