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2. Effects of dexamethasone on human synovial fibroblast-like cells, from osteoarthritic joints, in culture

Author

F. Piccione, Maria Valeria Torregrossa, Renza Vento, Michela Giuliano, G. Grecomoro, VENTO, R, TORREGROSSA, MV, GIULIANO, M, GRECOMORO, G, and PICCIONE, F

Subjects
endocrine system, medicine.medical_specialty, Time Factors, Cell division, Hydrocortisone, Somatic cell, Cell Survival, Cell Count, Biology, General Biochemistry, Genetics and Molecular Biology, Dexamethasone, Cell Line, chemistry.chemical_compound, Internal medicine, Osteoarthritis, Synovial Fluid, polycyclic compounds, medicine, Synovial fluid, Humans, General Pharmacology, Toxicology and Pharmaceutics, Fibroblast, Cell growth, General Medicine, DNA, Fibroblasts, Molecular biology, culture, Endocrinology, medicine.anatomical_structure, chemistry, Cell culture, RNA, Thymidine, hormones, hormone substitutes, and hormone antagonists, Cell Division, medicine.drug
Abstract

The effect of Dexamethasone (DEX) on cell division and macromolecular synthesis was investigated in a line (McCoy cells, A 9) of synovial fibroblast-like cells derived from human osteoarthritic joints. DEX markedly reduced the proliferation of McCoy cells in a time and dose-dependent manner. The maximal inhibition (45%) was found at 500 nM DEX 24 h after incubation and was accompanied by the appearance of giant macrophage-like cells. After DEX treatment cells showed increased content of DNA, proteins and RNA together with the reduction of [3H]-thymidine incorporation into the TCA-precipitable fraction.

Published
1990

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