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Start Over Author "Lishmanov, Y B" Journal life sciences
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2. Participation of central kappa-opioid receptor in arrhythmogenesis.

Author

Lishmanov YB, Maslov LN, Ugdyzhekova DS, and Smagin GN

Subjects
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Animals, Dynorphins pharmacology, Epinephrine, Hexamethonium pharmacology, Male, Naloxone pharmacology, Naltrexone analogs & derivatives, Naltrexone pharmacology, Narcotic Antagonists pharmacology, Peptide Fragments pharmacology, Pyrrolidines pharmacology, Rats, Rats, Wistar, Receptors, Opioid, kappa agonists, Receptors, Opioid, kappa antagonists & inhibitors, Arrhythmias, Cardiac chemically induced, Receptors, Opioid, kappa physiology
Abstract

The effect of kappa receptors agonists and antagonists was studied in the model of epinephrine induced arrhythmias. Kappa receptor agonists U-50,488 and [D-Ala2]-Dynorphin A (1-13) administered I.C.V. potentiate the arrhythmogenic effect of epinephrine. The effect of U-50,488 was completely blocked by kappa receptor antagonist, nor-binaltorphine. Administration of N-cholinergic receptor inhibitor, hexamethonium, prevented pro-arrhythmic effects of U-50,488 and [D-Ala2]-Dynorphin A (1-13). The data support the hypothesis that central kappa opioid receptors play an important role in the arrhythmogenesis.

Published
1997
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