1. Activation of central sympathetic neurons by angiotensin II
- Author
-
K.L. Keim and E.B. Sigg
- Subjects
Male ,Left vertebral artery ,medicine.medical_specialty ,Sympathetic Nervous System ,Autonomic Fibers, Preganglionic ,Hypothalamus ,Action Potentials ,Baroreflex ,Tachyphylaxis ,General Biochemistry, Genetics and Molecular Biology ,Internal medicine ,medicine ,Animals ,General Pharmacology, Toxicology and Pharmaceutics ,Vertebral Artery ,Neurons ,business.industry ,Angiotensin II ,Sympathetic nerve activity ,General Medicine ,Electric Stimulation ,Endocrinology ,Injections, Intra-Arterial ,Cats ,Female ,Hypothalamic stimulation ,business - Abstract
The injection of AT II in doses of 0.001 to 1.0 ug into the left vertebral artery caused an increase in spontaneous preganglionic cervical sympathetic nerve activity. This response showed tachyphylaxis and was independent of the vasopressor response. The enhancement of sympathetic discharges in response to hypothalamic stimulation was unaltered by AT II. It is concluded that one of the many different effects of AT II on the autonomic system involves a central sympathetic component.
- Published
- 1971
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