1. Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases.
- Author
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Mehta, Pakhuri, Miszta, Przemysław, Rzodkiewicz, Przemysław, Michalak, Olga, Krzeczyński, Piotr, and Filipek, Sławomir
- Subjects
HISTAMINE receptors ,G protein coupled receptors ,INTERLEUKIN-4 ,LIGANDS (Biochemistry) ,DISEASES ,PULMONARY fibrosis ,MAST cells - Abstract
The histamine H
4 receptor, belonging to the family of G-protein coupled receptors, is an increasingly attractive drug target. It plays an indispensable role in many cellular pathways, and numerous H4 R ligands are being studied for the treatment of several inflammatory, allergic, and autoimmune disorders, including pulmonary fibrosis. Activation of H4 R is involved in cytokine production and mediates mast cell activation and eosinophil chemotaxis. The importance of this receptor has also been shown in inflammatory models: peritonitis, respiratory tract inflammation, colitis, osteoarthritis, and rheumatoid arthritis. Recent studies suggest that H4 R acts as a modulator in cancer, neuropathic pain, vestibular disorders, and type-2 diabetes, however, its role is still not fully understood. [ABSTRACT FROM AUTHOR]- Published
- 2020
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