1. Evidence for regulation of oxidative stress by latent membrane protein 1 oncoprotein in patients with low-grade leukemic B cell lymphoma with latent Epstein-Barr virus infection
- Author
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Elina Kontandreopoulou, Vasiliki Papadopoulou, Eleni Variami, Athanasios Galanopoulos, Katerina Polonyfi, Panagoula Kollia, Panagiotis Kouzis, Gerassimos A. Pangalis, Theodoros Iliakis, Konstantinos Zervakis, Christine Kyrtsonis, George Vaiopoulos, Theodoros P. Vassilakopoulos, Nora-Athina Viniou, Panagiotis T. Diamantopoulos, Despoina Perrea, and Nikolaos Spanakis
- Subjects
Male ,Cancer Research ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,Lymphoma, B-Cell ,Gene Expression ,Biology ,Virus ,Pathogenesis ,Viral Matrix Proteins ,hemic and lymphatic diseases ,medicine ,Humans ,B-cell lymphoma ,Epstein–Barr virus infection ,Lactate Dehydrogenases ,B cell ,Aged ,Aged, 80 and over ,Oncogene Proteins ,Hematology ,Middle Aged ,medicine.disease ,Lymphoma ,Oxidative Stress ,medicine.anatomical_structure ,Oncology ,Proto-Oncogene Proteins c-bcl-2 ,Apoptosis ,Immunology ,Female ,Neoplasm Grading ,Lymphoid leukemia - Abstract
The role of latent Epstein-Barr virus (EBV) infection in the pathogenesis of low-grade B cell non-Hodgkin lymphoma (B-NHL) has not been studied. We therefore investigated the incidence of latent EBV infection in a group of patients with leukemic low-grade B-NHL, as well as the incidence of viral latent membrane protein 1 (LMP1) oncoprotein expression in the same patient group. Furthermore, in an attempt to elucidate the role of this viral oncoprotein in non-EBV-related lymphomas, we correlated the expression of LMP1 with the level of oxidative stress, a parameter related to apoptosis. In the present study we detected lower levels of oxidative stress in the sera of LMP1-positive patients. This possibly implies an anti-apoptotic role of this viral oncoprotein in low-grade B cell lymphomas. However, LMP1 expression status did not affect expression of the major anti-apoptotic gene BCL-2.
- Published
- 2013