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Your search keyword '"Luana Fianchi"' showing total 11 results
Start Over Author "Luana Fianchi" Journal leukemia research
11 results on '"Luana Fianchi"'

1. Topic: AS04-MDS Biology and Pathogenesis/AS04d-Somatic mutations

Author

Sabrina Giammarco, Giovanni Scambia, Gessica Minnella, Luana Fianchi, Monica Rossi, Simona Sica, Anna Fagotti, Elisabetta Metafuni, Vanda Salutari, Claudia Marchetti, P Chiusolo, and M. Di Stefano

Subjects
Pathogenesis, Genetics, Cancer Research, Oncology, Somatic cell, Hematology, Biology
Published
2021

2. Expression Profile of Bone Marrow Mesenchymal Stromal Cells Isolated from Patients with Therapy-Related Myeloid Neoplasms

Author

Francesco Buccisano, Luana Fianchi, Emiliano Fabiani, Luca Maurillo, M.T. Voso, Giulia Falconi, Stefan Hohaus, Marianna Criscuolo, Luca Laurenti, Tiziana Ottone, F. D’Alò, and Francesco Lo-Coco

Subjects
Cancer Research, Myeloid, Stromal cell, Therapy related, business.industry, Mesenchymal stem cell, Hematology, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Oncology, medicine, Cancer research, Bone marrow, business, 030215 immunology
Published
2017

3. Impaired bactericidal and fungicidal activities of neutrophils in patients with myelodysplastic syndrome

Author

Brunella Posteraro, Caterina Giovanna Valentini, Livio Pagano, Maria Teresa Voso, Luana Fianchi, Giuseppe Leone, Francesco Guidi, and Maurizio Sanguinetti

Subjects
Adult, Male, Blood Bactericidal Activity, Cancer Research, Neutrophils, Cells, medicine.disease_cause, Aged, Aged, 80 and over, Candida albicans, Case-Control Studies, Cells, Cultured, Escherichia coli, Female, Humans, Lactococcus lactis, Leukemia, Myelomonocytic, Chronic, Middle Aged, Myelodysplastic Syndromes, Prognosis, Risk Factors, hemic and lymphatic diseases, 80 and over, medicine, Chronic, Cultured, Leukemia, biology, Myelodysplastic syndromes, Case-control study, Myelomonocytic, Hematology, medicine.disease, biology.organism_classification, In vitro, Oncology, Immunology, Settore MED/15 - Malattie del Sangue
Abstract

Infections are a major cause of morbidity and mortality in patients with myelodysplastic syndrome (MDS) due to quantitative and qualitative granulocytic defects. We evaluated the in vitro bactericidal and fungicidal activities of neutrophils isolated from MDS. With comparison to those from healthy individuals, MDS neutrophils following infection showed a significantly reduced killing activity against Escherichia coli at 8 (p=0.002), 24 (p

Published
2012

4. Azacitidine in a patient with myelodysplastic syndrome: Impact of switching from a 5-day to the approved 7-day dosing schedule

Author

Marco Greco, Livio Pagano, Stefan Hohaus, Francesco D'Alo', Marianna Criscuolo, Luana Fianchi, Giuseppe Leone, and Maria Teresa Voso

Subjects
Male, Antimetabolites, Antineoplastic, Cancer Research, Schedule, Pediatrics, medicine.medical_specialty, Time Factors, Antimetabolites, Azacitidine, Pharmacology, Drug Administration Schedule, Dose-Response Relationship, medicine, Drug approval, Humans, Dosing, Aged, Disease Progression, Dose-Response Relationship, Drug, Drug Approval, Myelodysplastic Syndromes, business.industry, Myelodysplastic syndromes, Disease progression, Hematology, medicine.disease, Antineoplastic, Settore MED/15 - MALATTIE DEL SANGUE, Oncology, Drug, business, medicine.drug
Published
2012

7. 198 OUTCOME OF AZACITIDINE TREATMENT AND INCIDENCE OF FEBRILE EVENTS IN 'REAL WORLD' PATIENTS WITH MDS OR LOW-BLAST COUNT AML

Author

Maria Antonietta Aloe-Spiriti, Susanna Fenu, Luca Maurillo, Annalina Piccioni, Adriano Venditti, Luana Fianchi, Andrea Tendas, Massimo Breccia, Roberto Latagliata, Alfonso Piciocchi, Gina Zini, Francesco Buccisano, G. Mansueto, Livio Pagano, N. Filardi, M.T. Voso, R. Fragasso, Pellegrino Musto, Marianna Criscuolo, and Pasquale Niscola

Subjects
Cancer Research, medicine.medical_specialty, Oncology, business.industry, Incidence (epidemiology), Internal medicine, Azacitidine, Medicine, Hematology, business, Blast Count, Outcome (game theory), medicine.drug
Published
2015

8. MTHFR polymorphisms' influence on outcome and toxicity in acute lymphoblastic leukemia patients

Author

Giovanni Reddiconto, Alessia Fiorini, Patrizia Chiusolo, Giuseppe La Torre, Giuliana Farina, Luca Laurenti, Mariangela Palladino, Simona Sica, Alice Mannocci, Federica Sorà, Giuseppe Leone, and Luana Fianchi

Subjects
Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Adolescent, Drug-Related Side Effects and Adverse Reactions, Genotype, Lymphoblastic Leukemia, Relapse free survival, Recurrence, Internal medicine, medicine, Humans, Point Mutation, Child, Survival rate, Childhood Acute Lymphoblastic Leukemia, Methylenetetrahydrofolate Reductase (NADPH2), Aged, Polymorphism, Genetic, biology, business.industry, Hematology, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Survival Rate, Methotrexate, Treatment Outcome, Methylenetetrahydrofolate reductase, Toxicity, Immunology, biology.protein, Female, business, medicine.drug
Abstract

Recently the influence of polymorphisms of different genes involved in metabolism of chemoterapic agents have been studied especially in childhood acute lymphoblastic leukemia (ALL). We evaluated the influence of C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms on time to relapse and survival and on methotrexate (MTX) toxicity in 82 ALL adult patients. Relapse free survival and event free survival between homozygous wild-type and variant patients in both polymorphisms were not significantly different. However, we observed an association between 677TT variant and survival in a subset of ALL patients homogenously treated with MTX-based maintenance (p=0.02). In the same subgroup we confirmed the role of 677TT variant on toxicity during MTX treatment (p=0.003).

Published
2006

9. C002 Polymorphisms of DNA-repair and detoxification enzymes in myelodysplastic syndromes

Author

M.T. Voso, Francesco Guidi, Livio Pagano, F. D’Alò, Luana Fianchi, Stefan Hohaus, Alessandra Scardocci, Giuseppe Leone, A Di Ruscio, Emiliano Fabiani, and Mariangela Greco

Subjects
Genetics, Cancer Research, Oncology, DNA repair, business.industry, Myelodysplastic syndromes, medicine, Cancer research, Hematology, Detoxification enzymes, medicine.disease, business
Published
2007

10. 192 Response to 5-azacytidine in therapy-related malignant neoplasms (t-MN)

Author

M.T. Voso, Luca Maurillo, E.N. Oliva, Marianna Criscuolo, Luana Fianchi, A. Levis, Livio Pagano, Giuseppe Leone, Carlo Finelli, Mariangela Greco, and Pellegrino Musto

Subjects
Cancer Research, Therapy related, Oncology, business.industry, Cancer research, Medicine, Hematology, business
Published
2011

11. P025 Dap-kinase hypermethylation and apoptosis in myelodysplastic syndromes

Author

A Di Ruscio, Daniela Gumiero, S. Rutella, Stefan Hohaus, Alessandra Scardocci, Mariangela Greco, Emiliano Fabiani, Giuseppe Leone, M.T. Voso, Francesco Guidi, Silvia Bellesi, Luana Fianchi, and F. D’Alò

Subjects
Cancer Research, Oncology, Apoptosis, business.industry, Myelodysplastic syndromes, DNA methylation, medicine, Cancer research, Hematology, medicine.disease, DAP Kinase, business
Published
2007

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