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Your search keyword '"Lorand-Metze, Irene"' showing total 14 results
Start Over Author "Lorand-Metze, Irene" Journal leukemia research
14 results on '"Lorand-Metze, Irene"'

13. Reduced expression of FLIP SHORT in bone marrow of low risk myelodysplastic syndrome

Author

Campos, Paula de Melo, Traina, Fabíola, Duarte, Adriana da Silva Santos, Lorand-Metze, Irene, Costa, Fernando F., and Saad, Sara T.O.

Subjects
*APOPTOSIS, *BONE marrow, *CANCER research, *MEDICAL care research
Abstract

Abstract: Apoptosis is dysregulated in patients with myelodysplastic syndrome (MDS) and acute myelogenous leukaemia (AML). FLIP (FLICE (FAS-associated death-domain-like IL-1beta-converting enzyme)-inhibitory protein) has been described as an anti-apoptotic protein. Here, we characterize the expression level of FLIP LONG and FLIP SHORT mRNA in bone marrow aspirates from 61 patients diagnosed with MDS or AML. FLIP SHORT mRNA expression was significantly lower in low risk MDS, compared to high risk MDS, according to FAB classification (RA/RARS versus RAEB/RAEBt, P =0.0127) and IPSS (low risk/intermediate-1 versus intermediate-2/high risk, P =0.0345). Furthermore, FLIP SHORT mRNA expression was significantly lower in low risk MDS, compared to MDS-AML/AML de novo (P =0.0006), according to FAB classification. FLIP LONG expression did not differ between these groups. Increased levels of FLIP SHORT in RAEB and AML may be related to apoptosis resistance in these diseases and to MDS progression. [Copyright &y& Elsevier]

Published
2007
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14. Reduced expression of FLIP SHORT in bone marrow of low risk myelodysplastic syndrome.

Author

de Melo Campos P, Traina F, da Silva Santos Duarte A, Lorand-Metze I, Costa FF, and Saad ST

Subjects
Adult, Aged, Aged, 80 and over, Apoptosis Regulatory Proteins genetics, CASP8 and FADD-Like Apoptosis Regulating Protein metabolism, Female, Humans, Leukemia, Myeloid, Acute genetics, Male, Middle Aged, Myelodysplastic Syndromes genetics, Risk Factors, Apoptosis, Apoptosis Regulatory Proteins biosynthesis, CASP8 and FADD-Like Apoptosis Regulating Protein biosynthesis, Gene Expression Regulation, Leukemic, Leukemia, Myeloid, Acute metabolism, Myelodysplastic Syndromes metabolism
Abstract

Apoptosis is dysregulated in patients with myelodysplastic syndrome (MDS) and acute myelogenous leukaemia (AML). FLIP (FLICE (FAS-associated death-domain-like IL-1 beta-converting enzyme)-inhibitory protein) has been described as an anti-apoptotic protein. Here, we characterize the expression level of FLIP(LONG) and FLIP(SHORT) mRNA in bone marrow aspirates from 61 patients diagnosed with MDS or AML. FLIP(SHORT) mRNA expression was significantly lower in low risk MDS, compared to high risk MDS, according to FAB classification (RA/RARS versus RAEB/RAEBt, P=0.0127) and IPSS (low risk/intermediate-1 versus intermediate-2/high risk, P=0.0345). Furthermore, FLIP(SHORT) mRNA expression was significantly lower in low risk MDS, compared to MDS-AML/AML de novo (P=0.0006), according to FAB classification. FLIP(LONG) expression did not differ between these groups. Increased levels of FLIP(SHORT) in RAEB and AML may be related to apoptosis resistance in these diseases and to MDS progression.

Published
2007
Full Text
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