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Your search keyword '"Christina, Cox"' showing total 3 results
Start Over Author "Christina, Cox" Journal leukemia research
3 results on '"Christina, Cox"'

1. Cell of origin (COO), BCL2/MYC status and IPI define a group of patients with Diffuse Large B-cell Lymphoma (DLBCL) with poor prognosis in a real-world clinical setting

Author

Valentina Donati, Sara Galimberti, Stefano Sacchi, Stefania Bettelli, Tamar Tadmor, Pellegrino Musto, Aaron Polliack, Martina Quintini, Raffaella Marcheselli, Elisa Forti, Robel Papotti, Luigi Marcheselli, Antonino Maiorana, Samantha Pozzi, L. Flenghi, Arianna Di Napoli, Vittoria Lalinga, Giovanna Mansueto, and M. Christina Cox

Subjects
Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Poor prognosis, Vincristine, Cyclophosphamide, Lymphoma, cell of origin (COO), BCL2/MYC status, IPI, Diffuse Large B-cell Lymphoma (DLBCL), Adolescent, Cell of origin, Proto-Oncogene Proteins c-myc, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Doxorubicin, Female, Humans, Middle Aged, Prednisone, Retrospective Studies, Rituximab, Lymphoma, Large B-Cell, Diffuse, Proto-Oncogene Proteins c-bcl-2, Internal medicine, medicine, 80 and over, Large B-Cell, business.industry, Hematology, medicine.disease, Diffuse, business, Diffuse large B-cell lymphoma, medicine.drug
Published
2020

3. New reciprocal translocation t(6;10) (q27;q11) associated with idiopathic myelofibrosis and eosinophilia

Author

M. Christina Cox, Adriano Venditti, Paola Panetta, Giovanni Del Poeta, Maria Cantonetti, Sergio Amadori, and Elisabetta Abruzzese

Subjects
Male, Cancer Research, Pathology, Settore MED/06 - Oncologia Medica, myeloproliferative disorder, Myelofibrosis, Chromosomal translocation, Trisomy 8, cytogenetics, Translocation, Genetic, hemic and lymphatic diseases, Eosinophilia, Pair 11, Leukemia, article, case report, chromosome aberration, chromosome translocation, chromosome translocation 10, chromosome translocation 6, clinical feature, eosinophilia, extramedullary hematopoiesis, human, idiopathic disease, male, myelofibrosis, myelophthisic anemia, priority journal Adult, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 6, Disease Progression, Humans, Leukemia, Monocytic, Acute, Myeloproliferative Disorders, Hematology, Oncology, Pair 6, medicine.symptom, Adult, medicine.medical_specialty, Translocation, Biology, Acute, Chromosomes, Genetic, medicine, Monocytic, Cytogenetics, Chromosome, medicine.disease, Primary Myelofibrosis, Immunology, Trisomy, Settore MED/15 - Malattie del Sangue
Abstract

Idiopathic myelofibrosis (IM), is a chronic myeloproliferative disorder (MPD) characterised by marrow fibrosis, extramedullary haematopoiesis and a leuco-erythroblastic picture of the peripheral blood. Cytogenetic data of IM is scarce: no specific karyotypic anomalies have been yet described. Trisomy 1q, del(13q), del(20q) and trisomy 8, appear in two-thirds of the cases with chromosome aberrations. We report on a 41-year-old patient diagnosed with IM associated with eosinophilia, bearing a novel translocation t(6;10)(q27;q11) as the sole chromosome anomaly. The patient, progressed to AML-M5a within 18 months from diagnosis. Recently new specific chromosomal translocations have been described in chronic MPD. These findings have allowed the classification of new syndromes with defined molecular abnormalities. The case we describe, because of the peculiar clinical features and the association with a previously unreported chromosomal translocation, might be a noteworthy addition.

Published
2001

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