1. Clinical significance of CD70 expression on T cells in human T-lymphotropic virus type-1 carriers and adult T cell leukemia/ lymphoma patients.
- Author
-
Masamoto I, Yoshimitsu M, Kuroki A, Horai S, Ezinne CC, Kozako T, Hachiman M, Kamada Y, Baba M, and Arima N
- Subjects
- Adult, Aged, Aged, 80 and over, Antigens, CD genetics, Antigens, CD metabolism, CD27 Ligand genetics, Cell Line, Tumor, Female, Gene Expression, Gene Products, tax genetics, Gene Products, tax metabolism, HTLV-I Infections immunology, Humans, Immunophenotyping, Male, Middle Aged, Phenotype, T-Lymphocytes pathology, T-Lymphocytes, Cytotoxic immunology, T-Lymphocytes, Cytotoxic metabolism, CD27 Ligand metabolism, HTLV-I Infections complications, HTLV-I Infections virology, Human T-lymphotropic virus 1 immunology, Leukemia-Lymphoma, Adult T-Cell etiology, Leukemia-Lymphoma, Adult T-Cell metabolism, T-Lymphocytes metabolism
- Abstract
Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATL). Miscellaneous host immune surveillance systems control T-cell growth/leukemogenesis during HTLV-1 infection. We characterized CD70 and CD27 expression on lymphocytes of HTLV-1 carriers and patients with ATL (study approved by the local Medical Ethical Committee). High CD70 expression was observed on CD4 + CD25+ T cells from patients with acute-type ATL, while patients with smoldering- or chronic-type ATL and HTLV-1 carriers exhibited lower expression. Furthermore, significantly higher CD27 expression was observed on HTLV-1-specific CTLs. We found an association between CD70 expression on CD4 + T cells and HTLV-1 infection; increased CD70 expression was observed after exposure to Tax. Moreover, addition of anti-CD70 antibodies enhanced the CD107a surface mobilization of HTLV-1 Tax-specific CTLs following Tax-peptide stimulation in the PBMCs of carriers. These data demonstrate the important role of the CD70/CD27 axis in immune responses in HTLV-1 carriers and ATL patients.
- Published
- 2016
- Full Text
- View/download PDF