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Your search keyword '"Vuppusetty C"' showing total 2 results
Start Over Author "Vuppusetty C" Journal leukemia (08876924)
2 results on '"Vuppusetty C"'

1. Activation of the mTOR signaling pathway by L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts.

Author

Yip, B H, Vuppusetty, C, Attwood, M, Giagounidis, A, Germing, U, Lamikanra, A A, Roberts, D J, Maciejewski, J P, Vandenberghe, P, Mecucci, C, Wainscoat, J S, Pellagatti, A, and Boultwood, J

Subjects
*LEUCINE, *CELL growth, *PROGENITOR cells, *PHOSPHORYLATION, *RIBOSOMAL proteins, *MYELODYSPLASTIC syndromes, *MTOR protein
Abstract

The article presents a study which examines the potential role of L-leucine in cell growth and human erythroid progenitor cells. It analyzes the effects of L-leucine on the phosphorylation levels of ribosomal protein gene RPS14-deficient erythroblasts in patients with del(5q) myelodysplastic syndromes (MDS) and mTORC1 signaling. It suggests that L-leucine treatment may result to the improvement of erythroid defect in patients with del(5q) MDS.

Published
2013
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2. Effects of L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts.

Author

Yip, B H, Pellagatti, A, Vuppusetty, C, Giagounidis, A, Germing, U, Lamikanra, A A, Roberts, D J, Fernandez-Mercado, M, McDonald, E-J, Killick, S, Wainscoat, J S, and Boultwood, J

Subjects
LETTERS to the editor, LEUCINE, MYELODYSPLASTIC syndromes
Abstract

A letter to the editor is presented regarding a study of the effects of L-leucine in RPS14-deficient erythroblasts, such as 5q- syndrome.

Published
2012
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