1. Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases.
- Author
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Murati, A, Gervais, C, Carbuccia, N, Finetti, P, Cervera, N, Adélaïde, J, Struski, S, Lippert, E, Mugneret, F, Tigaud, I, Penther, D, Bastard, C, Poppe, B, Speleman, F, Baranger, L, Luquet, I, Cornillet-Lefebvre, P, Nadal, N, Nguyen-Khac, F, and Pérot, C
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ACUTE myeloid leukemia ,GENOMICS ,DNA microarrays ,ACUTE leukemia ,GENE expression - Abstract
The t(8;16)(p11;p13) is a rare translocation involved in de novo and therapy-related myelomonocytic and monocytic acute leukemia. It fuses two genes encoding histone acetyltransferases (HATs), MYST3 located at 8p11 to CREBBP located at 16p13. Variant translocations involve other HAT-encoding genes such as EP300, MYST4, NCOA2 or NCOA3. MYST3-linked acute myeloid leukemias (AMLs) share specific clinical and biological features and a poor prognosis. Because of its rarity, the molecular biology of MYST3-linked AMLs remains poorly understood. We have established the genome and gene expression profiles of a multicentric series of 61 M4/M5 AMLs including 18 MYST3-linked AMLs by using array comparative genome hybridization (aCGH) (n=52) and DNA microarrays (n=44), respectively. We show that M4/5 AMLs have a variety of rare genomic alterations. One alteration, a gain of the MYB locus, was found recurrently and only in the MYST3-linked AMLs (7/18 vs 0/34). MYST3-AMLs have also a specific a gene expression profile, which includes overexpression of MYB, CD4 and HOXA genes. These features, reminiscent of T-cell acute lymphoid leukemia (ALL), suggest the targeting of a common T-myeloid progenitor.Leukemia (2009) 23, 85–94; doi:10.1038/leu.2008.257; published online 25 September 2008 [ABSTRACT FROM AUTHOR]
- Published
- 2009
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