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Your search keyword '"Yacoub, Abdulraheem"' showing total 5 results
Start Over Author "Yacoub, Abdulraheem" Journal leukemia & lymphoma
5 results on '"Yacoub, Abdulraheem"'

1. Safety and efficacy of fedratinib in patients with myelofibrosis previously treated with ruxolitinib: primary analysis of FREEDOM trial

Author

Gupta, Vikas, primary, Yacoub, Abdulraheem, additional, Mesa, Ruben A., additional, Harrison, Claire N., additional, Vannucchi, Alessandro M., additional, Kiladjian, Jean-Jacques, additional, Deeg, Hans-Joachim, additional, Fazal, Salman, additional, Foltz, Lynda, additional, Mattison, Ryan J., additional, Miller, Carole B., additional, Parameswaran, Vinod, additional, Brown, Patrick, additional, Hernandez, Christopher, additional, Wang, Jia, additional, and Talpaz, Moshe, additional

Published
2024
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2. Use of endpoints in phase III randomized controlled trials for acute myeloid leukemia over the last 15 years: a systematic review

Author

Shahzad, Moazzam, primary, Chaudhary, Sibgha Gull, additional, Tariq, Ezza, additional, Mushtaq, Ali Hassan, additional, Anwar, Iqra, additional, Ahmed, Nausheen, additional, Bansal, Rajat, additional, Lutfi, Forat, additional, Balusu, Ramesh, additional, Abdelhakim, Haitham, additional, Yacoub, Abdulraheem, additional, Hematti, Peiman, additional, Singh, Anurag K., additional, McGuirk, Joseph P., additional, and Mushtaq, Muhammad Umair, additional

Published
2022
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3. Outcomes after venetoclax with hypomethylating agents in myelodysplastic syndromes: a systematic review and meta-analysis

Author

Khanam, Razwana, primary, Shahzad, Moazzam, additional, Chaudhary, Sibgha Gull, additional, Ali, Fatima, additional, Shah, Zunairah, additional, Pachika, Pranali S., additional, Ahmed, Zahoor, additional, Chattaraj, Asmi, additional, Masood, Adeel, additional, Ahmed, Nausheen, additional, Bansal, Rajat, additional, Balusu, Ramesh, additional, Shune, Leyla, additional, Anwar, Faiz, additional, Hematti, Peiman, additional, McGuirk, Joseph P., additional, Yacoub, Abdulraheem, additional, and Mushtaq, Muhammad Umair, additional

Published
2022
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4. Use of endpoints in phase III randomized controlled trials for acute myeloid leukemia over the last 15 years: a systematic review.

Author

Shahzad, Moazzam, Chaudhary, Sibgha Gull, Tariq, Ezza, Mushtaq, Ali Hassan, Anwar, Iqra, Ahmed, Nausheen, Bansal, Rajat, Lutfi, Forat, Balusu, Ramesh, Abdelhakim, Haitham, Yacoub, Abdulraheem, Hematti, Peiman, Singh, Anurag K., McGuirk, Joseph P., and Mushtaq, Muhammad Umair

Subjects
ACUTE myeloid leukemia, OVERALL survival, PROGRESSION-free survival
Abstract

We systematically evaluated the primary and secondary endpoints used in acute myeloid leukemia (AML) phase III randomized controlled trials (RCTs). We included 238 phase III AML RCTs in the past 15 years that reported 279 primary endpoints and 657 secondary endpoints. Overall survival (OS), progression-free survival (PFS), event-free survival (EFS), and complete remission (CR) were primary endpoints in 120 (43%), 34 (12%), 30 (11%), and 41 (15%) studies, respectively. OS (12.5%), PFS (13.2%), CR (14%), safety (11%), and EFS (9%) were commonly reported secondary endpoints. Among primary endpoints, a higher use of OS (OR 2.03, 95%CI 1.10–3.75, p = 0.023) and lower use of PFS (OR 0.25, 95%CI 0.12–0.52, p < 0.001) was observed from 2014 to 2021 compared to 2006–2013; CR was frequently used in relapsed/refractory compared to frontline RCTs (OR 2.20, 95%CI 1.11–4.38, p = 0.025); EFS was frequently used in frontline compared to relapsed/refractory AML RCTs (OR 10.11, 95%CI 1.34–76.34, p = 0.025). A higher trend in the use of clinically meaningful and objective endpoint of OS over the last 15 years. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Phase 1/2 study of cyclin-dependent kinase (CDK)4/6 inhibitor palbociclib (PD-0332991) with bortezomib and dexamethasone in relapsed/refractory multiple myeloma

Author

Niesvizky, Ruben, primary, Badros, Ashraf Z., additional, Costa, Luciano J., additional, Ely, Scott A., additional, Singhal, Seema B., additional, Stadtmauer, Edward A., additional, Haideri, Nisreen A., additional, Yacoub, Abdulraheem, additional, Hess, Georg, additional, Lentzsch, Suzanne, additional, Spicka, Ivan, additional, Chanan-Khan, Asher A., additional, Raab, Marc S., additional, Tarantolo, Stefano, additional, Vij, Ravi, additional, Zonder, Jeffrey A., additional, Huang, Xiangao, additional, Jayabalan, David, additional, Di Liberto, Maurizio, additional, Huang, Xin, additional, Jiang, Yuqiu, additional, Kim, Sindy T., additional, Randolph, Sophia, additional, and Chen-Kiang, Selina, additional

Published
2015
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