1. Chronic Lymphocytic Leukemia Complicated by Plasmacytoma Originating from Different Clones
- Author
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Naoyuki Yahata, Hiroshi Iwama, Tetsuzo Tauchi, Kazuma Ohyashiki, Osamu Iwase, Kawanishi Y, and Hiromi Serizawa
- Subjects
endocrine system ,Cancer Research ,Immunoglobulin gamma-Chains ,Chronic lymphocytic leukemia ,Immunoglobulin light chain ,Immunoglobulin kappa-Chains ,Immunoglobulin lambda-Chains ,immune system diseases ,hemic and lymphatic diseases ,medicine ,Humans ,neoplasms ,Gene ,B cell ,Genes, Immunoglobulin ,biology ,Neoplasms, Second Primary ,Hematology ,Middle Aged ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,Clone Cells ,Blot ,Blotting, Southern ,Leukemia ,medicine.anatomical_structure ,Oncology ,Immunology ,biology.protein ,Cancer research ,Plasmacytoma ,Female ,Antibody - Abstract
In a woman with chronic lymphocytic leukemia (CLL), a plasmacytoma developed on the back region after four years. CLL cases complicated with plasmacytoma are rare. In the present case, the plasmacytoma showed kappa cytoplasmic immunoglobulin (Ig), and the CLL showed gamma lambda surface Ig. To reveal the clonal origin of CLL and plasmacytoma, we analyzed Ig gene rearrangements in the patient's peripheral blood and plasmacytoma. Ig gene DNA analysis confirmed the presence of different rearrangements in the heavy and light chain genes of CLL and plasmacytoma. These findings suggest that in this patient, the two B cell malignancies arose from expansion of two phenotypically and genotypically distinct clones.
- Published
- 2000
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