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Your search keyword '"Mazur, Grzegorz"' showing total 9 results
Start Over Author "Mazur, Grzegorz" Journal leukemia & lymphoma
9 results on '"Mazur, Grzegorz"'

1. Cereblon (CRBN) gene polymorphisms predict clinical response and progression-free survival in relapsed/refractory multiple myeloma patients treated with lenalidomide: a pharmacogenetic study from the IMMEnSE consortium

Author

Iskierka-Jażdżewska, Elżbieta, primary, Canzian, Federico, additional, Stępień, Anna, additional, Martino, Alessandro, additional, Campa, Daniele, additional, Stein, Angelica, additional, Krawczyk-Kuliś, Małgorzata, additional, Rybicka-Ramos, Malwina, additional, Kyrcz-Krzemień, Sławomira, additional, Butrym, Aleksandra, additional, Mazur, Grzegorz, additional, Jurczyszyn, Artur, additional, Zawirska, Daria, additional, Grząśko, Norbert, additional, Tomczak, Waldemar, additional, Subocz, Edyta, additional, Wątek, Marzena, additional, Pasiarski, Marcin, additional, Rymko, Marcin, additional, Całbecka, Małgorzata, additional, Druzd-Sitek, Agnieszka, additional, Walewski, Jan, additional, Kruszewski, Marcin, additional, Raźny, Małgorzata, additional, Zaucha, Jan Maciej, additional, Dudziński, Marek, additional, Gaj, Paweł, additional, Robak, Tadeusz, additional, Warzocha, Krzysztof, additional, and Jamroziak, Krzysztof, additional

Published
2019
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2. Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study

Author

Campa, Daniele, primary, Martino, Alessandro, additional, Macauda, Angelica, additional, Dudziński, Marek, additional, Suska, Anna, additional, Druzd-Sitek, Agnieszka, additional, Raab, Marc-Steffen, additional, Moreno, Victor, additional, Huhn, Stefanie, additional, Butrym, Aleksandra, additional, Sainz, Juan, additional, Szombath, Gergely, additional, Rymko, Marcin, additional, Marques, Herlander, additional, Lesueur, Fabienne, additional, Vangsted, Annette Juul, additional, Vogel, Ulla, additional, Kruszewski, Marcin, additional, Subocz, Edyta, additional, Buda, Gabriele, additional, Iskierka-Jażdżewska, Elżbieta, additional, Ríos, Rafael, additional, Merz, Maximilian, additional, Schöttker, Ben, additional, Mazur, Grzegorz, additional, Perrial, Emeline, additional, Martinez-Lopez, Joaquin, additional, Butterbach, Katja, additional, García Sanz, Ramón, additional, Goldschmidt, Hartmut, additional, Brenner, Hermann, additional, Jamroziak, Krzysztof, additional, Reis, Rui Manuel, additional, Kadar, Katalin, additional, Dumontet, Charles, additional, Wątek, Marzena, additional, Haastrup, Eva Kannik, additional, Helbig, Grzegorz, additional, Jurczyszyn, Artur, additional, Jerez, Andrés, additional, Varkonyi, Judit, additional, Barington, Torben, additional, Grzasko, Norbert, additional, Zaucha, Jan Maciej, additional, Andersen, Vibeke, additional, Zawirska, Daria, additional, and Canzian, Federico, additional

Published
2019
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3. Cereblon (CRBN) gene polymorphisms predict clinical response and progression-free survival in relapsed/refractory multiple myeloma patients treated with lenalidomide: a pharmacogenetic study from the IMMEnSE consortium.

Author

Iskierka-Jażdżewska, Elżbieta, Canzian, Federico, Stępień, Anna, Martino, Alessandro, Campa, Daniele, Stein, Angelica, Krawczyk-Kuliś, Małgorzata, Rybicka-Ramos, Malwina, Kyrcz-Krzemień, Sławomira, Butrym, Aleksandra, Mazur, Grzegorz, Jurczyszyn, Artur, Zawirska, Daria, Grząśko, Norbert, Tomczak, Waldemar, Subocz, Edyta, Wątek, Marzena, Pasiarski, Marcin, Rymko, Marcin, and Całbecka, Małgorzata

Subjects
MULTIPLE myeloma, PROGRESSION-free survival, GENETIC polymorphisms, SINGLE nucleotide polymorphisms, CONSORTIA, CD38 antigen
Abstract

Cereblon (CRBN) is crucial for antiproliferative and immunomodulatory properties of immunomodulatory drugs. The objective of this study was to verify whether germline single nucleotide polymorphisms (SNPs) in the CRBN gene may influence response to lenalidomide in multiple myeloma (MM). Fourteen tagging SNPs covering the genetic variability in the CRBN gene region were genotyped in 167 Polish patients with refractory/relapsed MM treated with lenalidomide-based regimens. We found that carriers of minor alleles of two studied CRBN SNPs rs1714327G > C (OR = 0.26; 95% CI = 0.1–0.67; p =.0055, Bonferroni corrected p =.033) and rs1705814T > C (OR = 0.22; 95% CI = 0.07–0.65; p =.0063, Bonferroni corrected p =.037) were significantly associated with lower probability of achievement at least partial remission while treated with lenalidomide-based regimens, using the dominant inheritance model. Moreover, one of these SNPs, namely rs1705814T > C, was correlated with shorter progression-free survival (HR = 2.49; 95%CI = 1.31–4.74, p =.0054, Bonferroni corrected p =.033). It is suggested that selected germline CRBN allelic variants (rs1714327G > C and rs1705814T > C) affect lenalidomide efficacy in patients with relapsed/refractory MM. [ABSTRACT FROM AUTHOR]

Published
2020
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4. Phase III, randomized study of ofatumumab versus physicians’ choice of therapy and standard versus extended-length ofatumumab in patients with bulky fludarabine-refractory chronic lymphocytic leukemia

Author

Österborg, Anders, primary, Udvardy, Miklós, additional, Zaritskey, Andrey, additional, Andersson, Per-Ola, additional, Grosicki, Sebastian, additional, Mazur, Grzegorz, additional, Kaplan, Polina, additional, Steurer, Michael, additional, Schuh, Anna, additional, Montillo, Marco, additional, Kryachok, Iryna, additional, Middeke, Jan Moritz, additional, Kulyaba, Yaroslav, additional, Rekhtman, Grygoriy, additional, Gorczyca, Michele, additional, Daly, Siobhan, additional, Chang, Chai-Ni, additional, Lisby, Steen, additional, and Gupta, Ira, additional

Published
2016
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9. Unclassifiable small B-cell lymphoma with marked plasmacytic differentiation and Mott cell formation.

Author

Butrym, Aleksandra, Prochorec-Sobieszek, Monika, Dzietczenia, Justyna, and Mazur, Grzegorz

Subjects
LYMPHOMA diagnosis, DIFFERENTIAL diagnosis, IMMUNOHISTOCHEMISTRY, B cell lymphoma, PLASMA cells, CELL differentiation
Abstract

The article presents a case study of a 54-year-old man who underwent radiographs and computed tomography (CT) to evaluate a growing skin tumor on his left thigh and lymph node enlargement. An immunohistochemical analysis was performed and he was diagnosed with unclassifiable small B-cell lymphoma with marked plasmacytic differentiation and Mott cell formation. The article discusses the challenges of differential diagnosis in marginal zone lymphoma (MZL) with plasmacytic differentiation.

Published
2014
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