1. Murine Schnurri-2 controls natural killer cell function and lymphoma development.
- Author
-
Yamashita, Junji, Iwamura, Chiaki, Mitsumori, Kunitoshi, Hosokawa, Hiroyuki, Sasaki, Tetsuya, Takahashi, Munehisa, Tanaka, Hitoshi, Kaneko, Kenji, Hanazawa, Asami, Watanabe, Yukiko, Shinoda, Kenta, Tumes, Damon, Motohashi, Shinichiro, and Nakayama, Toshinori
- Subjects
- *
KILLER cells , *CELL physiology , *T-cell lymphoma , *ZINC-finger proteins , *GROWTH factors , *CELLULAR signal transduction , *LYMPHOCYTES , *CELL-mediated cytotoxicity - Abstract
Schnurri (Shn)-2 is a large zinc finger-containing protein implicated in cell growth, signal transduction and lymphocyte development. Here, we report that Shn-2-deficient ( Shn-2−//−) mice develop CD3-positive lymphoma spontaneously. In Shn-2−//− mice, we observed decreased cytotoxicity of natural killer (NK) cells accompanied by decreased expression of perforin and granzyme-B. In addition, phosphorylation of signal transducer and activator of transcription (STAT) 5 was reduced in Shn-2−//− NK cells, while phosphorylation of STAT3 and protein expression of nuclear factor-κB p65 subunit were enhanced in Shn-2−//− NK cells. Moreover, cell-surface expression of activation molecules such as CD27, CD69 and CD122 were decreased on Shn-2−//− NK cells. Thus, Shn-2 is considered to play an important role in the activation and function of NK cells and the development of T cell lymphoma in vivo. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF