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12 results on '"Staudt L"'

2. Recurrent activating mutations of CD28 in peripheral T-cell lymphomas

Author

Rohr, J, Guo, S, Huo, J, Bouska, A, Lachel, C, Li, Y, Simone, P D, Zhang, W, Gong, Q, Wang, C, Cannon, A, Heavican, T, Mottok, A, Hung, S, Rosenwald, A, Gascoyne, R, Fu, K, Greiner, T C, Weisenburger, D D, Vose, J M, Staudt, L M, Xiao, W, Borgstahl, G E O, Davis, S, Steidl, C, McKeithan, T, Iqbal, J, and Chan, W C

Published
2016
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4. Array-based DNA methylation profiling in follicular lymphoma

Author

O'Riain, C, O'Shea, D M, Yang, Y, Le Dieu, R, Gribben, J G, Summers, K, Yeboah-Afari, J, Bhaw-Rosun, L, Fleischmann, C, Mein, C A, Crook, T, Smith, P, Kelly, G, Rosenwald, A, Ott, G, Campo, E, Rimsza, L M, Smeland, E B, Chan, W C, Johnson, N, Gascoyne, R D, Reimer, S, Braziel, R M, Wright, G W, Staudt, L M, Lister, T A, and Fitzgibbon, J

Published
2009
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5. Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma

Author

Iqbal, J, Greiner, T C, Patel, K, Dave, B J, Smith, L, Ji, J, Wright, G, Sanger, W G, Pickering, D L, Jain, S, Horsman, D E, Shen, Y, Fu, K, Weisenburger, D D, Hans, C P, Campo, E, Gascoyne, R D, Rosenwald, A, Jaffe, E S, Delabie, J, Rimsza, L, Ott, G, Müller-Hermelink, H K, Connors, J M, Vose, J M, McKeithan, T, Staudt, L M, and Chan, W C

Published
2007
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6. Array-based DNA methylation profiling in follicular lymphoma

Author

OʼRiain, C, OʼShea, D M, Yang, Y, Le Dieu, R, Gribben, J G, Summers, K, Yeboah-Afari, J, Bhaw-Rosun, L, Fleischmann, C, Mein, C A, Crook, T, Smith, P, Kelly, G, Rosenwald, A, Ott, G, Campo, E, Rimsza, L M, Smeland, E B, Chan, W C, Johnson, N, Gascoyne, R D, Reimer, S, Braziel, R M, Wright, G W, Staudt, L M, Lister, T A, and Fitzgibbon, J

Published
2009

8. Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets

Author

Karube, K, primary, Enjuanes, A, additional, Dlouhy, I, additional, Jares, P, additional, Martin-Garcia, D, additional, Nadeu, F, additional, Ordóñez, G R, additional, Rovira, J, additional, Clot, G, additional, Royo, C, additional, Navarro, A, additional, Gonzalez-Farre, B, additional, Vaghefi, A, additional, Castellano, G, additional, Rubio-Perez, C, additional, Tamborero, D, additional, Briones, J, additional, Salar, A, additional, Sancho, J M, additional, Mercadal, S, additional, Gonzalez-Barca, E, additional, Escoda, L, additional, Miyoshi, H, additional, Ohshima, K, additional, Miyawaki, K, additional, Kato, K, additional, Akashi, K, additional, Mozos, A, additional, Colomo, L, additional, Alcoceba, M, additional, Valera, A, additional, Carrió, A, additional, Costa, D, additional, Lopez-Bigas, N, additional, Schmitz, R, additional, Staudt, L M, additional, Salaverria, I, additional, López-Guillermo, A, additional, and Campo, E, additional

Published
2017
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9. Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma

Author

Bouska, A, primary, Zhang, W, additional, Gong, Q, additional, Iqbal, J, additional, Scuto, A, additional, Vose, J, additional, Ludvigsen, M, additional, Fu, K, additional, Weisenburger, D D, additional, Greiner, T C, additional, Gascoyne, R D, additional, Rosenwald, A, additional, Ott, G, additional, Campo, E, additional, Rimsza, L M, additional, Delabie, J, additional, Jaffe, E S, additional, Braziel, R M, additional, Connors, J M, additional, Wu, C-I, additional, Staudt, L M, additional, D‘Amore, F, additional, McKeithan, T W, additional, and Chan, W C, additional

Published
2016
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10. Recurrent activating mutations of CD28 in peripheral T-cell lymphomas

Author

Rohr, J, primary, Guo, S, additional, Huo, J, additional, Bouska, A, additional, Lachel, C, additional, Li, Y, additional, Simone, P D, additional, Zhang, W, additional, Gong, Q, additional, Wang, C, additional, Cannon, A, additional, Heavican, T, additional, Mottok, A, additional, Hung, S, additional, Rosenwald, A, additional, Gascoyne, R, additional, Fu, K, additional, Greiner, T C, additional, Weisenburger, D D, additional, Vose, J M, additional, Staudt, L M, additional, Xiao, W, additional, Borgstahl, G E O, additional, Davis, S, additional, Steidl, C, additional, McKeithan, T, additional, Iqbal, J, additional, and Chan, W C, additional

Published
2015
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11. Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets

Author

Karube, K, Enjuanes, A, Dlouhy, I, Jares, P, Martin-Garcia, D, Nadeu, F, Ordóñez, G R, Rovira, J, Clot, G, Royo, C, Navarro, A, Gonzalez-Farre, B, Vaghefi, A, Castellano, G, Rubio-Perez, C, Tamborero, D, Briones, J, Salar, A, Sancho, J M, Mercadal, S, Gonzalez-Barca, E, Escoda, L, Miyoshi, H, Ohshima, K, Miyawaki, K, Kato, K, Akashi, K, Mozos, A, Colomo, L, Alcoceba, M, Valera, A, Carrió, A, Costa, D, Lopez-Bigas, N, Schmitz, R, Staudt, L M, Salaverria, I, López-Guillermo, A, and Campo, E

Abstract

Genome studies of diffuse large B-cell lymphoma (DLBCL) have revealed a large number of somatic mutations and structural alterations. However, the clinical significance of these alterations is still not well defined. In this study, we have integrated the analysis of targeted next-generation sequencing of 106 genes and genomic copy number alterations (CNA) in 150 DLBCL. The clinically significant findings were validated in an independent cohort of 111 patients. Germinal center B-cell and activated B-cell DLBCL had a differential profile of mutations, altered pathogenic pathways and CNA. Mutations in genes of the NOTCH pathway and tumor suppressor genes (TP53/CDKN2A), but not individual genes, conferred an unfavorable prognosis, confirmed in the independent validation cohort. A gene expression profiling analysis showed that tumors with NOTCH pathway mutations had a significant modulation of downstream target genes, emphasizing the relevance of this pathway in DLBCL. An in silico drug discovery analysis recognized 69 (46%) cases carrying at least one genomic alteration considered a potential target of drug response according to early clinical trials or preclinical assays in DLBCL or other lymphomas. In conclusion, this study identifies relevant pathways and mutated genes in DLBCL and recognizes potential targets for new intervention strategies.

Published
2018
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