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Your search keyword '"Paganin, M"' showing total 6 results
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6 results on '"Paganin, M"'

5. Minimal residual disease is an important predictive factor of outcome in children with relapsed ‘high-risk’ acute lymphoblastic leukemia

Author

Francesco Locatelli, Maddalena Paganin, Katia Polato, Giulia Fabbri, Marco Zecca, Andrea Biondi, Carmelo Rizzari, Giuseppe Basso, Paganin, M, Zecca, M, Fabbri, G, Polato, K, Biondi, A, Rizzari, C, Locatelli, F, and Basso, G

Subjects
Male, Oncology, Cancer Research, Neoplasm, Residual, medicine.medical_treatment, Predictive Value of Test, Hematopoietic stem cell transplantation, Risk Factors, Recurrence, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Medicine, Prospective Studies, Child, Prospective cohort study, Multivariate Analysi, Mercaptopurine, Reverse Transcriptase Polymerase Chain Reaction, Hematopoietic Stem Cell Transplantation, Cytarabine, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Combined Modality Therapy, Treatment Outcome, Vincristine, Child, Preschool, Predictive value of tests, Female, Survival Analysi, Human, medicine.drug, 6-Mercaptopurine, medicine.medical_specialty, Adolescent, Cyclophosphamide, Prognosi, Disease-Free Survival, Predictive Value of Tests, Internal medicine, Humans, Asparaginase, Survival analysis, Antineoplastic Combined Chemotherapy Protocol, business.industry, Risk Factor, Daunorubicin, Infant, Survival Analysis, Minimal residual disease, Surgery, body regions, Prospective Studie, Methotrexate, Multivariate Analysis, Prednisone, business
Abstract

The aim of the study was to analyze the impact of minimal residual disease (MRD) after reinduction therapy on the outcome of children with relapsed 'high-risk' acute lymphoblastic leukemia (ALL). Sixty patients with isolated or combined marrow relapse were studied. All patients belonged to the S3 or S4 groups, as defined by the Berlin-Frankfurt-Münster stratification for relapsed ALL. MRD was studied by real-time quantitative PCR after the first, second and third chemotherapy course (time points 1 (TP1), 2 (TP2) and 3 (TP3), respectively). MRD results, not used for treatment refinement, were categorized as negative (NEG MRD), positive not-quantifiable (POS-NQ MRD) when MRD level was below quantitative range (a level or=10(-4). With a median observation time of 15 months, overall 3-year event-free survival (EFS) was 27%. The 3-year EFS was 73, 45 and 19% for patients with NEG-MRD, POS NQ-MRD and POS-MRD at TP1, respectively (P

Published
2008

6. Acute lymphoblastic leukemia with t(4;11) in children 1 year and older: The ‘big sister’ of the infant disease?

Author

J. J. M. Van Dongen, V H J van der Velden, Alexander M. Dohnal, Helmut Gadner, Martin Schrappe, Georg Mann, E R Panzer-Grümayer, A Schrauder, Andrea Biondi, Thomas Flohr, Maddalena Paganin, Eva Csinady, Giovanni Cazzaniga, Mann, G, Cazzaniga, G, van der Velden, V, Flohr, T, Csinady, E, Paganin, M, Schrauder, A, Dohnal, A, Schrappe, M, Biondi, A, Gadner, H, van Dongen, J, Panzer Grümayer, E, and Immunology

Subjects
Cancer Research, Pediatrics, medicine.medical_specialty, Immunoglobulin Heavy Chain, Receptors, Antigen, T-Cell, Disease, Sister, Biology, Translocation, Genetic, Immunophenotyping, hemic and lymphatic diseases, Acute lymphocytic leukemia, medicine, Humans, Childhood Acute Lymphoblastic Leukemia, Neoplasm Staging, Acute leukemia, Genes, Immunoglobulin, Chromosomes, Human, Pair 11, Infant, hemic and immune systems, Hematology, Gene rearrangement, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Oncology, El Niño, Immunology, Chromosomes, Human, Pair 4, Immunoglobulin Heavy Chains
Abstract

The t(4;11)-positive acute lymphoblastic leukemia (ALL) is a rare disease in children above the age of 1 year. We studied the clinical and biological characteristics in 32 consecutively diagnosed childhood cases (median age 10.0 years, range 1.0-17.1 years). Immunophenotyping revealed a pro-B and a pre-B stage in 24 and eight cases, respectively. IGH genes were rearranged in 84% of leukemias with a predominance of incomplete DJ(H) joints. Whereas IGK-Kde and TCRD rearrangements were rare, TCRG rearrangements were present in 50% of cases and involved mainly Vgamma11 or Vgamma9 together with a Jgamma1.3./2.3 gene segment, an unusual combination among t(4;11)-negative B-cell precursor ALL. Oligoclonality was found in about 30% as assessed by heterogeneous IGH and TCRG rearrangements. Our data are in line with transformation of a precursor cell at an early stage of B-cell development but retaining the potential to differentiate to the pre-B cell stage in vivo. Although a distinct difference between infant and older childhood cases with t(4;11) became evident, no age-related biological features were found within the childhood age group. In contrast to infants with t(4;11)-positive ALL, childhood cases had a relatively low cumulative incidence of relapse of 25% at 3.5 years with BFM-based high-risk protocols.

Published
2007

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