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Your search keyword '"Mereu, E."' showing total 5 results
Start Over Author "Mereu, E." Journal leukemia
5 results on '"Mereu, E."'

3. Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22

Author

Arruga, F, primary, Gizdic, B, additional, Bologna, C, additional, Cignetto, S, additional, Buonincontri, R, additional, Serra, S, additional, Vaisitti, T, additional, Gizzi, K, additional, Vitale, N, additional, Garaffo, G, additional, Mereu, E, additional, Diop, F, additional, Neri, F, additional, Incarnato, D, additional, Coscia, M, additional, Allan, J, additional, Piva, R, additional, Oliviero, S, additional, Furman, R R, additional, Rossi, D, additional, Gaidano, G, additional, and Deaglio, S, additional

Published
2016
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4. The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma

Author

Piva, R, primary, Deaglio, S, additional, Famà, R, additional, Buonincontri, R, additional, Scarfò, I, additional, Bruscaggin, A, additional, Mereu, E, additional, Serra, S, additional, Spina, V, additional, Brusa, D, additional, Garaffo, G, additional, Monti, S, additional, Dal Bo, M, additional, Marasca, R, additional, Arcaini, L, additional, Neri, A, additional, Gattei, V, additional, Paulli, M, additional, Tiacci, E, additional, Bertoni, F, additional, Pileri, S A, additional, Foà, R, additional, Inghirami, G, additional, Gaidano, G, additional, and Rossi, D, additional

Published
2014
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5. Mutations in NOTCH1PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22

Author

Arruga, F, Gizdic, B, Bologna, C, Cignetto, S, Buonincontri, R, Serra, S, Vaisitti, T, Gizzi, K, Vitale, N, Garaffo, G, Mereu, E, Diop, F, Neri, F, Incarnato, D, Coscia, M, Allan, J, Piva, R, Oliviero, S, Furman, R R, Rossi, D, Gaidano, G, and Deaglio, S

Abstract

Even if NOTCH1is commonly mutated in chronic lymphocytic leukemia (CLL), its functional impact in the disease remains unclear. Using CRISPR/Cas9-generated Mec-1 cell line models, we show that NOTCH1 regulates growth and homing of CLL cells by dictating expression levels of the tumor suppressor gene DUSP22. Specifically, NOTCH1 affects the methylation of DUSP22promoter by modulating a nuclear complex, which tunes the activity of DNA methyltransferase 3A (DNMT3A). These effects are enhanced by PEST-domain mutations, which stabilize the molecule and prolong signaling. CLL patients with a NOTCH1-mutated clone showed low levels of DUSP22 and active chemotaxis to CCL19. Lastly, in xenograft models, NOTCH1-mutated cells displayed a unique homing behavior, localizing preferentially to the spleen and brain. These findings connect NOTCH1, DUSP22, and CCL19-driven chemotaxis within a single functional network, suggesting that modulation of the homing process may provide a relevant contribution to the unfavorable prognosis associated with NOTCH1mutations in CLL.

Published
2017
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