1. Administration of the phosphodiesterase type 4 inhibitor rolipram into the amygdala at a specific time interval after learning increases recognition memory persistence
- Author
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Martina Blank, Paulo Fernandes Costa Jobim, Raissa R. Christoff, Thiago Rodrigues Pedroso, Aline Werenicz, Nadja Schröder, Rafael Roesler, and Gustavo Kellermann Reolon
- Subjects
Male ,Phosphodiesterase Type 4 ,Time Factors ,Cognitive Neuroscience ,Specific time ,Pharmacology ,Amygdala ,Persistence (computer science) ,Cellular and Molecular Neuroscience ,medicine ,Animals ,Learning ,Rats, Wistar ,Rolipram ,Recognition memory ,Chi-Square Distribution ,Long-term memory ,Retention, Psychology ,Recognition, Psychology ,Rats ,Neuropsychology and Physiological Psychology ,medicine.anatomical_structure ,Exploratory Behavior ,Memory consolidation ,Phosphodiesterase 4 Inhibitors ,Psychology ,Photic Stimulation ,medicine.drug ,Cognitive psychology - Abstract
Here we show that administration of the phosphodiesterase type 4 (PDE4) inhibitor rolipram into the basolateral complex of the amygdala (BLA) at a specific time interval after training enhances memory consolidation and induces memory persistence for novel object recognition (NOR) in rats. Intra-BLA infusion of rolipram immediately, 1.5 h, or 6 h after training had no effect on retention tested at 1, 7, and 14 d later. However, rolipram infused 3 h post-training promoted memory persistence for up to at least 14 d. The findings suggest that PDE4 inhibition in the BLA can enhance long-term memory formation when induced specifically 3 h after learning.
- Published
- 2012