1. Factors associated with total laryngectomy following organ‐preserving treatment of laryngeal SCC
- Author
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Victor, Mitchell T, Faraji, Farhoud, Voora, Rohith, Kalavacherla, Sandhya, Mell, Loren K, Rose, Brent S, and Guo, Theresa W
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Cancer ,Good Health and Well Being ,laryngeal squamous cell carcinoma ,larynx preservation ,salvage laryngectomy ,recurrence ,Veterans Affairs - Abstract
ObjectivesA subset of laryngeal squamous cell carcinoma (LSCC) patients undergoing larynx preserving treatment ultimately require total laryngectomy (TL) for oncologic or functional reasons. This study aims to identify TL risk factors in these patients.MethodsRetrospective cohort study using Veterans Affairs (VA) database. T1-T4 LSCC cases treated with primary radiotherapy (XRT) or chemoradiotherapy (CRT) were assessed for TL and recurrence. Binary logistic and Cox regression and Kaplan-Meier analyses were implemented.ResultsOf 5390 cases, 863 (16.0%) underwent TL. On multivariable analysis, age (adjusted odds ratio: 0.97 [0.96-0.98]; p T1 disease (T2, 1.76 [1.44-2.17]; p
- Published
- 2024