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2. Protein-Eye View of the in Meso Crystallization Mechanism

Author

van ‘t Hag, Leonie, primary, de Campo, Liliana, additional, Tran, Nhiem, additional, Sokolova, Anna, additional, Trenker, Raphael, additional, Call, Matthew E., additional, Call, Melissa J., additional, Garvey, Christopher J., additional, Leung, Anna E., additional, Darwish, Tamim A., additional, Krause-Heuer, Anwen, additional, Knott, Robert, additional, Meikle, Thomas G., additional, Drummond, Calum J., additional, Mezzenga, Raffaele, additional, and Conn, Charlotte E., additional

Published
2019
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4. How Peptide Molecular Structure and Charge Influence the Nanostructure of Lipid Bicontinuous Cubic Mesophases: Model Synthetic WALP Peptides Provide Insights

Author

van ‘t Hag, Leonie, primary, Li, Xu, additional, Meikle, Thomas G., additional, Hoffmann, Søren V., additional, Jones, Nykola C., additional, Pedersen, Jan Skov, additional, Hawley, Adrian M., additional, Gras, Sally L., additional, Conn, Charlotte E., additional, and Drummond, Calum J., additional

Published
2016
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15. Investigation of the Effect of Sugar Stereochemistryon Biologically Relevant LyotropicPhases from Branched-Chain Synthetic Glycolipids by Small-Angle X-rayScattering.

Author

Zahid, N. Idayu, Conn, Charlotte E., Brooks, Nicholas J., Ahmad, Noraini, Seddon, John M., and Hashim, Rauzah

Subjects
*STEREOCHEMISTRY, *GLYCOLIPIDS, *X-ray scattering, *CELL membranes, *IONIC surfactants, *BIOTECHNOLOGY
Abstract

Synthetic branched-chain glycolipidsare suitable as model systemsin understanding biological cell membranes, particularly because certainnatural lipids possess chain branching. Herein, four branched-chainglycopyranosides, namely, 2-hexyl-decyl-α-d-glucopyranoside(α-Glc–OC10C6), 2-hexyl-decyl-β-d-glucopyranoside (β-Glc–OC10C6), 2-hexyl-decyl-α-d-galactopyranoside (α-Gal–OC10C6), and 2-hexyl-decyl-β-d-galactopyranoside(β-Gal–OC10C6), with a total alkylchain length of 16 carbon atoms have been synthesized, and their phasebehavior has been studied. The partial binary phase diagrams of thesenonionic surfactants in water were investigated by optical polarizingmicroscopy (OPM) and small-angle X-ray scattering (SAXS). The introductionof chain branching in the hydrocarbon chain region is shown to resultin the formation of inverse structures such as inverse hexagonal andinverse bicontinuous cubic phases. A comparison of the four compoundsshowed that they exhibited different polymorphism, especially in thethermotropic state, as a result of contributions from anomeric andepimeric effects according to their stereochemistry. The neat α-Glc–OC10C6compound exhibited a lamellar (Lα) phase whereas dry α-Gal–OC10C6formed an inverse bicontinuous cubic Ia3d(QIIG) phase. Both β-anomersof glucoside and galactoside adopted the inverse hexagonal phase (HII) in the dry state. Generally, in the presence of water,all four glycolipids formed inverse bicontinuous cubic Ia3d(QIIG) and Pn3m(QIID) phases over widetemperature and concentration ranges. The formation of inverse nonlamellarphases by these Guerbet branched-chain glycosides confirms their potentialas materials for novel biotechnological applications such as drugdelivery and crystallization of membrane proteins. [ABSTRACT FROM AUTHOR]

Published
2013
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