1. Rapid increase in inspired desflurane concentration does not elicit a hyperdynamic circulatory response in the pig
- Author
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Hans-Joachim Priebe, Jörg Haberstroh, Wolfgang Müller, and Waheedullah Karzai
- Subjects
Male ,Mean arterial pressure ,Time Factors ,Epinephrine ,Swine ,Blood Pressure ,Flunitrazepam ,Desflurane ,Catecholamines ,Heart Rate ,Heart rate ,medicine ,Animals ,Anesthesia ,GABA Modulators ,Propofol ,Vecuronium Bromide ,Isoflurane ,General Veterinary ,Chemistry ,Hemodynamics ,Anesthetics, Inhalation ,Breathing ,Female ,Animal Science and Zoology ,Premedication ,Anesthetics, Intravenous ,Preanesthetic Medication ,Neuromuscular Nondepolarizing Agents ,medicine.drug ,Blood sampling - Abstract
The effects of a rapid increase in inspired desflurane concentration on systemic haemodynamics and plasma catecholamines were studied in seven pigs (22-30 kg). Following premedication (flunitrazepam 0.4 mg/kg i.m.), anaesthesia was induced (propofol 2.5 mg/kg i.v., vecuronium 0.2 mg/kg i.v.), the trachea orally intubated, and ventilation controlled. Anaesthesia was maintained with N2O/O2 (70%/30%), propofol (50 μg/kg/min), desflurane 12% end-tidal concentration), and vecuronium (0.3 mg/kg/h). After cannulation of both femoral arteries for subsequent simultaneous systemic pressure measurements and blood sampling for determination of epinephrine (E) and norepinephrine (NE) plasma levels, N2O and propofol were discontinued, and FiO2 and end-tidal concentration of desflurane increased to >0.9 and 3%, respectively. Forty minutes later, the inspired concentration of desflurane was abruptly increased to 15%. Mean arterial pressure (MAP), heart rate (HR), and plasma concentrations of E and NE were determined before and 1, 2, 4, 8, 16, and 32 min after increasing the desflurane concentration. Plasma concentrations of E and NE were determined by high performance liquid chromatography (HPLC) with electrochemical detection. Data were analysed by repeated measures ANOVA (significance level P
- Published
- 1997