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According to different estimations, the systemic or topical administration of drugs is the 2nd or 3rd identified cause of urticarias. Urticaria may be the leading symptom of drug-induced immuno-allergic reactions such as anaphylaxis or serum sickness. More often, it is the manifestation of non-immune reactions by drug-induced direct release of histamine, activation of complement or enzymatic impairment of the metabolism of arachidonic acid derivatives. Skin tests may be helpful for the demonstration of the responsibility of drugs in the immuno-allergic reactions. Whatever the mechanism may be, one should dissuade from provocation reintroduction of the suspected drug without an extreme wariness.

At least, about a hundred of benign specific tumours originating in the epithelial and connective structures of the skin are nosologically individualized. In this count are not included all the clinicopathological variants of these entities and the numerous lesions which only look like tumours such viral warts or cheloidal scars. The most frequent benign skin tumours are seborrhoic keratoses, nevocytic nevi, dermatofibromas and hemangiomas. In this practical review we describe the most common tumours which have some clinical hallmarks and can be easily recognized without a histological checking.

The main cutaneous manifestation of allergy is eczema. In atopic dermatitis, the epidermal Langerhans cells express receptors for IgE and the eczematous lesions may be associated with other atopic disorders such as asthma or pollinosis. In contact dermatitis, the epidermal Langerhans' cells play the role of antigen-presenting cells; the antigens eliciting the eczematous lesions may be of occupational, vestimentary, cosmetical, therapeutical or other environmental origin. Epicutaneous test procedures enable their identification. Paraptic eczema is a concept including all the cutaneous and systemic complications of contact dermatitis.