1. Association of high-sensitivity C-reactive protein with susceptibility to Schizophrenia in Tunisian population
- Author
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A. Salmi, H Ben Ammar, Amine Larnaout, Ons Mihoub, Fayza Ayari, Z. El Hechmi, Sonia Gara, A. Ben Ammar El Gaaied, Rahma Nefzi, Fethi Guemira, Hayet Douik, Marion Leboyer, A. Ben Chaaben, Nesrine Ouni, Hajer Abaza, Ryad Tamouza, and A. Aissa
- Subjects
Adult ,Male ,Tunisia ,Adolescent ,Population ,Tunisian population ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Arts and Humanities (miscellaneous) ,Risk Factors ,Inflammatory marker ,Medicine ,Humans ,Association (psychology) ,education ,Aged ,education.field_of_study ,Genetic diversity ,biology ,business.industry ,C-reactive protein ,Genetic data ,Middle Aged ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,C-Reactive Protein ,Schizophrenia ,Case-Control Studies ,Immunology ,biology.protein ,Female ,Disease Susceptibility ,business ,Biomarkers - Abstract
The pathogenic mechanisms underlying Schizophrenia (SZ), one of the most frequent mental disorders, are complex and poorly understood. Several evidences suggest that inflammatory processes may underpin some of its neurobiological correlates. The aim of this study was: (i) to analyze the potential association between circulating levels of the C-reactive protein (CRP), a crucial inflammatory marker, and Schizophrenia in Tunisian patients and healthy controls (HC) cohorts; (ii) to investigate the genetic diversity of three CRP variants (rs1417938, rs1130864 and rs1205) and; (iii) to analyze a potential relationship between expression and genetic data and clinical and socio demographical characteristics. CRP polymorphisms were exanimated for 155 patients and 203 HC by taqMan5′-nuclease. High-sensitivity CRP (hs-CRP) serum level was measured in 128 clinically stable out-patient SZ patients and 63 HC subjects via an automated biochemical analyzer. We found that hs-CRP levels were significantly higher in SZ patients as compared to HC. No significant differences were found when the proportions of CRP variants were compared in patients and HC. Further analysis according to clinical and socio demographical characteristics revealed a positive association with age and hypertension. Our data on an original Tunisian sample confirm the previous finding in others population groups.
- Published
- 2019