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Background:  The effect of physical exercise on hypothyroidism exists argumentative and require more ferrets. Poor knowledge of the patients with hypothyroidism regarding physical exercise and Activity Daily Livings (ADLs) can change in their lifestyle, deteriorate symptoms and complications.   Objective: The main objective of the present research is to evaluate the effectiveness of an instructional program on hypothyroidism patients’ knowledge toward physical exercise and ADLs.   Methodology: one group study (pretest– posttest) a pre experimental design study was used to conduct this study at Baghdad teaching hospitals from 2th March, 2021 to 30th   Jun, 2021. A purposive sampling non probability was applied to select 50 patients with hypothyroidism were coming to Baghdad teaching hospitals. The validity of the questionnaire was verified by 20 experts. The reliability was determined the knowledge questionnaire by using (test and retest) approach. Statistics were used to analyze the results of the study using (SPSS) version (22). Results: Statistically significant differences found between the scores of the patients’ knowledge in two levels of measurements (pre- test and post-test) at (p<0.01), where the statistical global mean of score (GMS) for knowledge of patients regarding the physical exercise in pre-test was (0.195), while GMS . becomes (0.880) in post-test. Furthermore, there is no relationship among age, gender and level of education variables and hypothyroidism patients’ knowledge toward physical exercise and ADLs at (p>0.05) in pre and posttest. Conclusion: Poor knowledge of hypothyroidism patients’ toward physical exercise and Activity Daily Livings (ADLs) in (pretest) and clear improvement in their knowledge of the patients after applying the instructional program in (posttest) and there is no relationship between Socio- Demographic variables(Age, Gender and Level of education) with knowledge of hypothyroidism patients’ regard to physical exercise and  ADLs. Recommendations: The study recommends conduct further large cross- sectional studies on big populations to develop the knowledge of the patients and achieving the well-being of the society. [ABSTRACT FROM AUTHOR]