1. Natural Short-term Course of Recurrent Macular Edema Following Intravitreal Bevacizumab Therapy in Branch Retinal Vein Occlusion.
- Author
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Yoo SJ, Kim JH, Lee TG, Kim JW, Cho SW, and Han JI
- Subjects
- Aged, Aged, 80 and over, Angiogenesis Inhibitors administration & dosage, Angiogenesis Inhibitors adverse effects, Bevacizumab administration & dosage, Female, Fluorescein Angiography, Follow-Up Studies, Fovea Centralis pathology, Fundus Oculi, Humans, Intravitreal Injections, Macular Edema diagnosis, Male, Middle Aged, Recurrence, Retinal Vein Occlusion complications, Retinal Vein Occlusion diagnosis, Retrospective Studies, Tomography, Optical Coherence, Bevacizumab adverse effects, Macular Edema chemically induced, Retinal Vein Occlusion drug therapy
- Abstract
Purpose: To evaluate the 3-month natural course of recurrent macular edema secondary to branch retinal vein occlusion (BRVO) treated with intravitreal bevacizumab., Methods: This retrospective, observational study included 36 eyes with macular edema secondary to BRVO. All patients were initially treated with intravitreal bevacizumab for macular edema. Recurrence of macular edema was either not treated (untreated group) or treated with a single intravitreal bevacizumab injection (treated group). Central foveal thickness (CFT) and best-corrected visual acuity (BCVA) were compared at the time of recurrence and 3 months later., Results: At the time of recurrence, the mean CFT and logarithm of the minimum angle of resolution BCVA were 484.9 ± 124.1 µm and 0.58 ± 0.26 in the untreated group (n = 19) and 456.3 ± 126.8 µm and 0.51 ± 0.21 in the treated group (n = 17), respectively. Three months later, the mean CFT and BCVA had changed to 493.7 ± 123.9 µm and 0.62 ± 0.29 in the untreated group and 294.7 ± 104.4 µm and 0.40 ± 0.24 in the treated group, respectively. The differences in CFT and BCVA between the two time points were not significant in the untreated group ( p = 0.106 and p = 0.687, respectively), whereas statistically significant differences were noted in the treated group ( p = 0.002 and p < 0.001, respectively)., Conclusions: Unlike the first episode of macular edema following BRVO, recurrent macular edema following intravitreal bevacizumab therapy did not spontaneously resolve, suggesting the potential benefit of prompt treatment., Competing Interests: Conflict of Interest: No potential conflict of interest relevant to this article was reported.
- Published
- 2017
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