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Start Over Author "Schenk K" Journal klinische wochenschrift
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3. [Haemodynamic effects of furosemide and ethacrynic acid (author's transl)].

Author

Schenk KE, Biamino G, and Schröder R

Subjects
Acute Disease, Blood Pressure drug effects, Blood Vessels drug effects, Coronary Disease drug therapy, Ethacrynic Acid therapeutic use, Furosemide therapeutic use, Heart drug effects, Heart Atria physiopathology, Humans, Nitroglycerin pharmacology, Physical Exertion, Pulmonary Artery physiopathology, Vasodilator Agents, Ethacrynic Acid pharmacology, Furosemide pharmacology, Hemodynamics drug effects
Abstract

The haemodynamic effects of intravenous injections of furosemide and ethacrynic acid were studied in 12 patients during rest and exercise. Cardiac output, heart rate and arterial blood pressure showed no significant changes after injection of furosemide or ethacrynic acid. Few minutes after injection of furosemide there were significant falls of pulmonary artery diastolic pressure and right atrial pressure, whereas no changes were seen after injection of ethacrynic acid. This initial effect of furosemide apparently is of primarily vascular origin, causing an increased peripheral venous capacitance. Ethacrynic acid failed to exhibit any direct vascular effect.

Published
1975
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