Search

Showing total 47 results
Start Over Topic electrophoresis, paper Language german Journal klinische wochenschrift
47 results

46. [Paraproteins as the product of clonal immune proliferation--a contribution to the immunology and oncology of monoclonal proteins (author's transl)]

Author

O, Wetter

Subjects
Blood Protein Disorders, Antibodies, Neoplasm, Immune Sera, Blood Proteins, Cytotoxicity Tests, Immunologic, Antibodies, Immunoglobulin A, Epitopes, Mice, Immunoglobulin M, Agglutinins, Histocompatibility Antigens, Immunoglobulin G, Animals, Humans, Electrophoresis, Paper, Antibody-Producing Cells, Immunoelectrophoresis, Immunoglobulin Fragments, Antilymphocyte Serum, Autoantibodies, Plasmacytoma
Published
1973

47. [Alpha 1-anti trypsin-deficiency: combination of pulmonary emphysema and liver cirrhosis in infancy (author's transl)]

Author

D, Kaiser, O M, Rennert, H, Joller-Jemelka, H, Götze, H, Sollberger, and P, Kehrli

Subjects
Adult, Liver Cirrhosis, Heterozygote, Immunodiffusion, Blood Protein Disorders, Cholestasis, Homozygote, Proteins, Middle Aged, Pedigree, Respiratory Function Tests, Diagnosis, Differential, Erythroblastosis, Fetal, Nasal Mucosa, Phenotype, Pulmonary Emphysema, Pregnancy, Child, Preschool, Tears, alpha 1-Antitrypsin, alpha 1-Antitrypsin Deficiency, Humans, Electrophoresis, Paper, Female
Abstract

The combination of pulmonary emphysema and liver cirrhosis in early childhood is documented for the first time in a 31/2 year old girl with homozygous (ZZ) deficiency of a1-antitrypsin. Examination of relatives in the generation of parents and grand parents revealed 7 heterozygous (MS) and five normal members (MM). Lung function tests showed altered respiratory function in 4 out of these 7 heterozygous subjects. Measurement of trypsin inhibitory capacity in plasma gave a good correlation to the genotype, however determinations of a1-antitrypsin coincided with it to a lesser degree. A high trypsin inhibitory capacity was detected in the tears of the propositi, which was shown to be immunologically distinguishable from serum a1-antitrypsin. Similarly, antiprotease activity was demonstrated in nasal secretions. This too did not reflect the serum profile.

Published
1975