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Start Over Author "Safonova MV" Journal klinicheskaia meditsina
2 results on '"Safonova MV"'

1. [Colonic pathology in patients with liver cirrhosis].

Author

Safonova MV, Kozlova IV, Ovsyannikova VV, and Kvetnoy IM

Subjects
Capillaries pathology, Chromogranin A metabolism, Colonoscopy, Dilatation, Pathologic, Epithelial Cells metabolism, Female, Humans, Liver Cirrhosis complications, Male, Middle Aged, Serotonin metabolism, Colonic Diseases etiology, Colonic Diseases pathology, Intestinal Mucosa pathology, Liver Cirrhosis physiopathology
Abstract

The study of 146 patents with liver cirrhosis of different classes using clinical, endoscopic, morphological and immunohistochemical methods revealed characteristic colonic changes. The destructive and atrophic changes in colonic mucosa were associated with increased morphometric parameters of serotonin- and chromogranin A-positive epithelyocytes. Capillary dilatation in colonic mucosa developed earlier than rectal varicose veins and may be an earlier sign of portal colonopathy.

Published
2012

2. [Clinical and morphological features of gastric and duodenal lesions in patients with chronic hepatitis].

Author

Kozlova IV and Safonova MV

Subjects
Adult, Apoptosis, Cell Proliferation, Duodenal Diseases diagnosis, Duodenal Diseases metabolism, Endoscopy, Gastrointestinal, Endothelin-1 biosynthesis, Female, Hepatitis, Chronic diagnosis, Hepatitis, Chronic metabolism, Humans, Immunohistochemistry, Intestinal Mucosa metabolism, Intestinal Mucosa pathology, Male, Nitric Oxide Synthase biosynthesis, Prognosis, Severity of Illness Index, Stomach Diseases diagnosis, Stomach Diseases metabolism, Duodenal Diseases etiology, Hepatitis, Chronic complications, Stomach Diseases etiology
Abstract

Clinical presentation, endoscopic picture and morphological changes of gastric and duodenal mucosa were evaluated in 75 patients with chronic hepatitis of different (viral and non-viral) etiology. Endoscopic, morphological, and immunohistochemical studies revealed deterioration of morphometric characteristics of somatostatin-immunopositive epitheliocytes in gastric mucosa and their improvement in epitheliocytes producing endothelin-1 and nitric oxide synthase. These changes were associated with decreased proliferative activity and enhanced apoptosis of epitheliocytes in gastric mucosa.

Published
2008

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