1. [Density of lymphocyte beta-2 adrenoreceptors in the course of hypertension].
- Author
-
Parfenova EI, Krasnikova TL, D'iakonova EG, Masenko VP, Shinbaeva NA, Kivaeva GM, and Mazaev AV
- Subjects
- Adult, Centrifugation, Density Gradient, Follow-Up Studies, Humans, Hypertension complications, Hypertrophy, Left Ventricular physiopathology, Male, Middle Aged, Prognosis, Receptors, Adrenergic, beta-2 physiology, Time Factors, Hypertension physiopathology, Lymphocytes chemistry, Receptors, Adrenergic, beta-2 analysis
- Abstract
Baseline density of intact lymphocyte beta2 adrenoreceptors (B max., 3H-DHA) was compared to dynamics of left ventricular hypertrophy (LVH) and frequency of essential hypertension (EH) complications within 7-9-year follow-up in 27 patients with EH stage II. No significant correlation was noted between B max and LVH changes. In a subgroup of 9 patients with initially very high B max overall number of complications reached 77.8% against 27.5%) (p<0.05) in control. These patients also developed acute myocardial infarctions more frequently (33.3% versus 0%, p<0.05). Such complications as strokes, coronary failure occurred with the same frequency. More extended trials are needed to infer on prognostic value of lymphocytic beta2-adrenoreceptor density.
- Published
- 1995