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2 results on '"Robert Star"'

1. Epidemiology, molecular, and genetic methodologies to evaluate causes of CKDu around the world: report of the Working Group from the ISN International Consortium of Collaborators on CKDu

Author

Shuchi Anand, Ben Caplin, Marvin Gonzalez-Quiroz, Stephen L. Schensul, Vivek Bhalla, Xavier Parada, Nishantha Nanayakkara, Andrew Fire, Adeera Levin, David J. Friedman, Angie Aguilar-Gonzalez, Kevin Abbot, Thilak Abeysekara, Kerstin Amann, Gloria Ashuntantang, Daniel Brooks, Denis Chavarria, Daniel Christoph, Ricardo Correa Rotter, Marc De Broe, P. Mangala C.S. De Silva, Jose Dominguez, Kai-Uwe Eckardt, Dorien Fader, Fred Finkelstein, Rebecca Fischer, David Friedman, Anirban Ganguli, Ramon Antonio Garcia Trabinho, Jason Glaser, Marvin Antonio Gonzalez Quiroz, Lalarukh (Lali) Haider, David Harris, Chulani Herath, Raul Herrera, Anne Hradsky, Wendy Hoy, Kristina Jakobsson, Saroj Jayasinghe, Channa Jaysummana, Vivek Jha, Richard Johnson, Neeraja Kambham, Nishamani Karanasema, Francois Kaze, Paul Kimmel, Erik Koritzinsky, Robyn Langham, Laurent Le Bellego, Nathan Levin, Valerie Lyuckx, Magdalena Madero, Ekiti Martin, Charu Malik, Louise Moist, Marva Moxey-Mims, Andrew Narva, Fabiana Nerbass, Donal O'Donoghue, Carlos Orantes, Neil Pearce, Charaka Ratnayake, Prabheer Roy-Chaudhury, Agnese Ruggiero, Laura Gabriela Sanchez-Lozada, Rajiv Saran, Stephen Schensul, Luca Segantini, Isabelle Seksek, David Sheikh-Hamad, Robert Star, Luisa Strani, Penny Vlahos, David H. Wegman, Ilana Weiss, Eranga Wijewickrama, Julia Wijkstrom, Paul Wise, Emily Wright, Chih-Wei Yang, Karen Yeates, and Int Soc Nephrology's Int

Subjects
medicine.medical_specialty, business.industry, Interstitial nephritis, medicine.disease, Ethics, Research, Molecular Diagnostic Techniques, Nephrology, Family medicine, Epidemiology, Global health, Humans, Medicine, Molecular diagnostic techniques, Human medicine, Renal Insufficiency, Chronic, business
Published
2019

2. Dialysis dose and the effect of gender and body size on outcome in the HEMO Study

Author

Thomas Depner, John Daugirdas, Tom Greene, Michael Allon, Gerald Beck, Cameron Chumlea, James Delmez, Frank Gotch, John Kusek, Nathan Levin, Edwin Macon, Edgar Milford, William Owen, Robert Star, Robert Toto, Garabed Eknoyan, and null for the Hemodialysis (HEMO) Study Group

Subjects
Male, Risk, Nephrology, medicine.medical_specialty, Time Factors, body water volume, medicine.medical_treatment, Black People, survival, HEMO Study, law.invention, Randomized controlled trial, Renal Dialysis, law, Cause of Death, Internal medicine, gender, medicine, Humans, race, Dialysis, Cause of death, Sex Characteristics, hemodialysis, business.industry, Mortality rate, clinical trial, weight, Middle Aged, Kt/V, Surgery, Treatment Outcome, Body Constitution, Kidney Failure, Chronic, Female, Hemodialysis, body size, business, Body mass index
Abstract

Dialysis dose and the effect of gender and body size on outcome in the HEMO Study.BackgroundGender and body size have been associated with survival in hemodialysis populations. In recent observational studies, overall mortality was similar in men and women and higher in small patients. The effect of dialysis dose in each of these subgroups has not been tested in a clinical trial.MethodsThe HEMO Study was a controlled trial of dialysis dose and membrane flux in 1846 hemodialysis patients followed up for 6.6years in 15 centers throughout the United States. We examined the effect of dialysis dose on mortality and on selected secondary outcomes in subgroups of patients.ResultsAdjusting for age only, overall mortality was lower in patients with higher body weight (P < 0.001), higher body mass index (P < 0.001), and higher body water content determined by the Watson formula (Vw) (P < 0.001), but was not associated with gender (P = 0.27). The RR of mortality comparing the high dose with the standard dose group was related to gender (P = 0.014). Women randomized to the high dose had a lower mortality rate than women randomized to the standard dose (RR = 0.81, P = 0.02), while men randomized to the high dose had a nonsignificant trend for a higher mortality rate than men randomized to the standard dose (RR = 1.16, P = 0.16). Analysis of both genders combined showed no overall dose effect (R = 0.96, P = 0.52), as reported previously. Vw was greater than 35L in 84% of men compared with 17% of women. However, the RR of mortality for the high versus standard dose remained lower in women than in men after adjustment for the interaction of dose with Vw or with other size parameters, including weight and body mass index. Conversely, the dose effect was not significantly related to size parameters after controlling for the relationship of the dose comparison with gender.ConclusionThe data suggest that mortality and morbidity might be reduced by increasing the dialysis dose above the current standard in women but not in men. This effect was not explained by differences between men and women in age, race, or in several indices of body size. Because multiple comparisons were considered in this analysis, the role of gender on the effect of dialysis dose is suggestive and invites further study.

Published
2004
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