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40 results on '"Parikh, Chirag R."'

1. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events

Author

Menez, Steven, Wen, Yumeng, Xu, Leyuan, Moledina, Dennis G., Thiessen-Philbrook, Heather, Hu, David, Obeid, Wassim, Bhatraju, Pavan K., Ikizler, T. Alp, Siew, Edward D., Chinchilli, Vernon M., Garg, Amit X., Go, Alan S., Liu, Kathleen D., Kaufman, James S., Kimmel, Paul L., Himmelfarb, Jonathan, Coca, Steven G., Cantley, Lloyd G., and Parikh, Chirag R.

Published
2023
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2. Rationale and design of the Kidney Precision Medicine Project

Author

de Boer, Ian H, Alpers, Charles E, Azeloglu, Evren U, Balis, Ulysses GJ, Barasch, Jonathan M, Barisoni, Laura, Blank, Kristina N, Bomback, Andrew S, Brown, Keith, Dagher, Pierre C, Dighe, Ashveena L, Eadon, Michael T, El-Achkar, Tarek M, Gaut, Joseph P, Hacohen, Nir, He, Yongqun, Hodgin, Jeffrey B, Jain, Sanjay, Kellum, John A, Kiryluk, Krzysztof, Knight, Richard, Laszik, Zoltan G, Lienczewski, Chrysta, Mariani, Laura H, McClelland, Robyn L, Menez, Steven, Moledina, Dennis G, Mooney, Sean D, O’Toole, John F, Palevsky, Paul M, Parikh, Chirag R, Poggio, Emilio D, Rosas, Sylvia E, Rosengart, Matthew R, Sarwal, Minnie M, Schaub, Jennifer A, Sedor, John R, Sharma, Kumar, Steck, Becky, Toto, Robert D, Troyanskaya, Olga G, Tuttle, Katherine R, Vazquez, Miguel A, Waikar, Sushrut S, Williams, Kayleen, Wilson, Francis Perry, Zhang, Kun, Iyengar, Ravi, Kretzler, Matthias, Himmelfarb, Jonathan, Project, Kidney Precision Medicine, Lecker, Stewart, Stillman, Isaac, Waikar, Sushrut, Mcmahon, Gearoid, Weins, Astrid, Short, Samuel, Hoover, Paul, Aulisio, Mark, Cooperman, Leslie, Herlitz, Leal, O’Toole, John, Poggio, Emilio, Sedor, John, Jolly, Stacey, Appelbaum, Paul, Balderes, Olivia, Barasch, Jonathan, Bomback, Andrew, Canetta, Pietro A, d’Agati, Vivette D, Kudose, Satoru, Mehl, Karla, Radhakrishnan, Jai, Weng, Chenhua, Alexandrov, Theodore, Ashkar, Tarek, Barwinska, Daria, Dagher, Pierre, Dunn, Kenneth, Eadon, Michael, Ferkowicz, Michael, Kelly, Katherine, Sutton, Timothy, Winfree, Seth, Parikh, Chirag, Rosenberg, Avi, Villalobos, Pam, Malik, Rubab, Fine, Derek, Atta, Mohammed, Trujillo, Jose Manuel Monroy, Slack, Alison, Rosas, Sylvia, and Williams, Mark

Subjects
Clinical Research, Transplantation, Kidney Disease, Prevention, Renal and urogenital, Good Health and Well Being, Acute Kidney Injury, Adult, Humans, Kidney, Precision Medicine, Prospective Studies, Proteomics, Renal Insufficiency, Chronic, acute kidney injury, chronic kidney disease, diabetes, hypertension, precision medicine, Kidney Precision Medicine Project, Clinical Sciences, Urology & Nephrology
Abstract

Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.

Published
2021

3. A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death.

Author

Ikizler, T Alp, Parikh, Chirag R, Himmelfarb, Jonathan, Chinchilli, Vernon M, Liu, Kathleen D, Coca, Steven G, Garg, Amit X, Hsu, Chi-Yuan, Siew, Edward D, Wurfel, Mark M, Ware, Lorraine B, Faulkner, Georgia Brown, Tan, Thida C, Kaufman, James S, Kimmel, Paul L, Go, Alan S, and ASSESS-AKI Study Investigators

Subjects
ASSESS-AKI Study Investigators, Kidney, Humans, Cardiovascular Diseases, Glomerular Filtration Rate, Aftercare, Patient Discharge, Risk Factors, Prospective Studies, Adult, Acute Kidney Injury, acute kidney injury, acute renal failure, cardiovascular disease, chronic kidney disease, heart failure, mortality, Cardiovascular, Clinical Research, Kidney Disease, Aging, Renal and urogenital, Urology & Nephrology, Clinical Sciences
Abstract

Acute kidney injury (AKI) has been reported to be associated with excess risks of death, kidney disease progression and cardiovascular events although previous studies have important limitations. To further examine this, we prospectively studied adults from four clinical centers surviving three months and more after hospitalization with or without AKI who were matched on center, pre-admission CKD status, and an integrated priority score based on age, prior cardiovascular disease or diabetes mellitus, preadmission estimated glomerular filtration rate (eGFR) and treatment in the intensive care unit during the index hospitalization between December 2009-February 2015, with follow-up through November 2018. All participants had assessments of kidney function before (eGFR) and at three months and annually (eGFR and proteinuria) after the index hospitalization. Associations of AKI with outcomes were examined after accounting for pre-admission and three-month post-discharge factors. Among 769 AKI (73% Stage 1, 14% Stage 2, 13% Stage 3) and 769 matched non-AKI adults, AKI was associated with higher adjusted rates of incident CKD (adjusted hazard ratio 3.98, 95% confidence interval 2.51-6.31), CKD progression (2.37,1.28-4.39), heart failure events (1.68, 1.22-2.31) and all-cause death (1.78, 1.24-2.56). AKI was not associated with major atherosclerotic cardiovascular events in multivariable analysis (0.95, 0.70-1.28). After accounting for degree of kidney function recovery and proteinuria at three months after discharge, the associations of AKI with heart failure (1.13, 0.80-1.61) and death (1.29, 0.84-1.98) were attenuated and no longer significant. Thus, assessing kidney function recovery and proteinuria status three months after AKI provides important prognostic information for long-term clinical outcomes.

Published
2021

6. The SPRINT trial suggests that markers of tubule cell function in the urine associate with risk of subsequent acute kidney injury while injury markers elevate after the injury

Author

Bullen, Alexander L, Katz, Ronit, Lee, Alexandra K, Anderson, Cheryl AM, Cheung, Alfred K, Garimella, Pranav S, Jotwani, Vasantha, Haley, William E, Ishani, Areef, Lash, James P, Neyra, Javier A, Punzi, Henry, Rastogi, Anjay, Riessen, Erik, Malhotra, Rakesh, Parikh, Chirag R, Rocco, Michael V, Wall, Barry M, Bhatt, Udayan Y, Shlipak, Michael G, Ix, Joachim H, and Estrella, Michelle M

Subjects
Prevention, Kidney Disease, Clinical Research, Renal and urogenital, Good Health and Well Being, Acute Kidney Injury, Aged, Aged, 80 and over, Albuminuria, Alpha-Globulins, Biomarkers, Chitinase-3-Like Protein 1, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Interleukin-18, Kidney Tubules, Lipocalin-2, Longitudinal Studies, Male, Middle Aged, Renal Insufficiency, Chronic, Renal Reabsorption, Risk Assessment, Risk Factors, Uromodulin, acute kidney injury, alpha-1 microglobulin, beta-2 microglobulin, uromodulin, neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, interleukin-18, monocyte chemoattractant protein-1, chitinase-3-like protein, Clinical Sciences, Urology & Nephrology
Abstract

Urine markers can quantify tubular function including reabsorption (α-1 microglobulin [α1m]) and β-2-microglobulin [β2m]) and protein synthesis (uromodulin). Individuals with tubular dysfunction may be less able to compensate to insults than those without, despite similar estimated glomerular filtration rate (eGFR) and albuminuria. Among Systolic Blood Pressure Intervention Trial (SPRINT) participants with an eGFR under 60 ml/min/1.73m2, we measured urine markers of tubular function and injury (neutrophil gelatinase-associated lipocalin [NGAL], kidney injury molecule-1 [KIM-1], interleukin-18 [IL-18], monocyte chemoattractant protein-1, and chitinase-3-like protein [YKL-40]) at baseline. Cox models evaluated associations with subsequent acute kidney injury (AKI) risk, adjusting for clinical risk factors, baseline eGFR and albuminuria, and the tubular function and injury markers. In a random subset, we remeasured biomarkers after four years, and compared changes in biomarkers in those with and without intervening AKI. Among 2351 participants, 184 experienced AKI during 3.8 years mean follow-up. Lower uromodulin (hazard ratio per two-fold higher (0.68, 95% confidence interval [0.56, 0.83]) and higher α1m (1.20; [1.01, 1.44]) were associated with subsequent AKI, independent of eGFR and albuminuria. None of the five injury markers were associated with eventual AKI. In the random subset of 947 patients with repeated measurements, the 59 patients with intervening AKI versus without had longitudinal increases in urine NGAL, IL-19, and YKL-40 and only 1 marker of tubule function (α1m). Thus, joint evaluation of tubule function and injury provided novel insights to factors predisposing to AKI, and responses to kidney injury.

Published
2019

8. The authors reply

Author

Hu, David, primary, Menez, Steve, additional, Thiessen-Philbrook, Heather, additional, and Parikh, Chirag R., additional

Published
2024
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9. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

Author

Knight, Richard, Lecker, Stewart H., Stillman, Isaac, Bogen, Steve, Amodu, Afolarin A., Ilori, Titlayo, Maikhor, Shana, Schmidt, Insa M., Beck, Laurence H., Henderson, Joel M., Onul, Ingrid, Verma, Ashish, McMahon, Gearoid M., Valerius, M. Todd, Waikar, Sushrut, Weins, Astrid, Colona, Mia R., Greka, Anna, Hacohen, Nir, Hoover, Paul J., Marshall, Jamie L., Aulisio, Mark, Chen, Yijiang M., Janowczyk, Andrew, Jayapandian, Catherine, Viswanathan, Vidya S., Bush, William S., Crawford, Dana C., Madabhushi, Anant, Bush, Lakeshia, Cooperman, Leslie, Gonzalez-Vicente, Agustin, Herlitz, Leal, Jolly, Stacey, Nguyen, Jane, O’toole, John, Palmer, Ellen, Poggio, Emilio, Sedor, John, Sendrey, Dianna, Spates-Harden, Kassandra, Taliercio, Jonathan, Bjornstad, Petter M., Pyle, Laura, Vinovskis, Carissa, Appelbaum, Paul, Balderes, Olivia, Barasch, Jonathan M., Bomback, Andrew S., Canetta, Pietro A., D’Agati, Vivette D., Kiryluk, Krzysztof, Kudose, Satoru, Mehl, Karla, Shang, Ning, Bansal, Shweta, Alexandrov, Theodore, Rennke, Helmut, El-Achkar, Tarek M., Barwinska, Daria, Bledso, Sharon, Borner, Katy, Bueckle, Andreas, Cheng, Yinghua, Dagher, Pierre C., Dunn, Kenneth W., Eadon, Michael T., Ferkowicz, Michael J., Herr, Bruce W., Kelly, Katherine J., Ferreira, Ricardo Melo, Quardokus, Ellen M., Record, Elizabeth, Rivera, Marcelino, Su, Jing, Sutton, Timothy A., Williams, James C., Jr., Winfree, Seth, Jain, Yashvardhan, Menez, Steven, Parikh, Chirag R., Rosenberg, Avi, Corona-Villalobos, Celia P., Wen, Yumeng, Johansen, Camille, Rosas, Sylvia E., Roy, Neil, Sun, Jennifer, Williams, Mark, Azeloglu, Evren U., Hansen, Jens, He, Cijang, Iyengar, Ravi, Xiong, Yuguang, Prasad, Pottumarthi, Srivastava, Anand, Madhavan, Sethu M., Parikh, Samir, Rovin, Brad, Shapiro, John P., Anderton, Christopher R., Lukowski, Jessica, Pasa-Tolic, Ljiljana, Velickovic, Dusan, Oliver, George (Holt), Ardayfio, Joseph, Bebiak, Jack, Brown, Keith, Campbell, Taneisha, Campbell, Catherine E., Hayashi, Lynda, Jefferson, Nichole, Roberts, Glenda V., Saul, John, Shpigel, Anna, Stutzke, Christy, Koewler, Robert, Pinkeney, Roy, Sealfon, Rachel, Troyanskaya, Olga, Wong, Aaron, Tuttle, Katherine R., Pollack, Ari, Goltsev, Yury, Ginley, Brandon, Lucarelli, Nicholas, Lutnick, Brendon, Sarder, Pinaki, Lake, Blue B., Zhang, Kun, Boada, Patrick, Laszik, Zoltan G., Nolan, Garry, Anjani, Kavya, Sarwal, Minnie, Mukatash, Tariq, Sigdel, Tara, Alloway, Rita R., Burg, Ashley R., Lee, Paul J., Rike, Adele, Shi, Tiffany, Woodle, E. Steve, Ascani, Heather, Balis, Ulysses G.J., Blanc, Victoria M., Conser, Ninive C., Eddy, Sean, Frey, Renee, He, Yougqun, Hodgin, Jeffrey B., Kretzler, Matthias, Lienczewski, Chrysta, Luo, Jinghui, Mariani, Laura H., Menon, Rajasree, Otto, Edgar, Schaub, Jennifer, Steck, Becky, Elder, Michele M., Gilliam, Matthew, Hall, Daniel E., Murugan, Raghavan, Palevsky, Paul M., Randhawa, Parmjeet, Rosengart, Matthew, Tublin, Mitchell, Vita, Tina, Winters, James, Kellum, John A., Alpers, Charles E., Berglund, Ashley, Berry, Brooke, Blank, Kristina N., Carson, Jonas, Daniel, Stephen, De Boer, Ian H., Dighe, Ashveena L., Dowd, Frederick, Grewenow, Stephanie M., Himmelfarb, Jonathan, Hoofnagle, Andrew N., Limonte, Christine, McClelland, Robyn L., Mooney, Sean D., Rezaei, Kasra, Shankland, Stuart, Snyder, Jamie, Wang, Ruikang, Wilcox, Adam, Williams, Kayleen, Park, Christopher, Montellano, Richard, Pamreddy, Annapurna, Sharma, Kumar, Venkatachalam, Manjeri, Ye, Hongping, Zhang, Guanshi, Basit, Mujeeb, Hedayati, S. Susan, Kermani, Asra, Lee, Simon C., Lu, Christopher Y., Miller, R. Tyler, Moe, Orson W., Patel, Jiten, Pillai, Anil, Sambandam, Kamalanathan, Torrealba, Jose, Toto, Robert D., Vazquez, Miguel, Wang, Nancy, Wen, Natasha, Zhang, Dianbo, Park, Harold, Caprioli, Richard M., Patterson, Nathan, Sharman, Kavya, Spraggins, Jeffrey M., Van de Plas, Raf, Basta, Jeanine, Diettman, Sabine M., Gaut, Joseph P., Jain, Sanjay, Rauchman, Michael I., Vijayan, Anitha, Cantley, Lloyd G., Kakade, Vijaykumar R., Moledina, Dennis, Shaw, Melissa M., Ugwuowo, Ugochukwu, Wilson, Francis P., Arora, Tanima, Kestenbaum, Bryan R., Alexopoulos, Leonidas G., Palsson, Ragnar, Liu, Jing, Stillman, Isaac E., Rennke, Helmut G., Vaidya, Vishal S., Wu, Haojia, Humphreys, Benjamin D., and Waikar, Sushrut S.

Published
2021
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11. A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death

Author

Chinchilli, Vernon M., Go, Alan S., Himmelfarb, Jonathan, Ikizler, T. Alp, Kaufman, James S., Kimmel, Paul L., Parikh, Chirag R., Stokes, John B., Coca, Steven, Garg, Amit, Zheng, Sijie, Pravoverov, Leonid, Hsu, Chi-yuan, Hsu, Raymond K., Liu, Kathleen D., Reeves, W. Brian, Siew, Edward D., Lewis, Julia B., Ware, Lorraine, Devarajan, Prasad, Krawczeski, Catherine, Bennett, Michael, Zappitelli, Michael, Wurfel, Mark, Coca, Steven G., Garg, Amit X., Wurfel, Mark M., Ware, Lorraine B., Faulkner, Georgia Brown, and Tan, Thida C.

Published
2021
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13. Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Author

Menon, Rajasree, primary, Bomback, Andrew S., additional, Lake, Blue B., additional, Stutzke, Christy, additional, Grewenow, Stephanie M., additional, Menez, Steven, additional, D’Agati, Vivette D., additional, Jain, Sanjay, additional, Knight, Richard, additional, Lecker, Stewart H., additional, Stillman, Isaac, additional, Bogen, Steve, additional, Beck, Laurence H., additional, Waikar, Sushrut, additional, McMahon, Gearoid M., additional, Weins, Astrid, additional, Colona, Mia R., additional, Hacohen, Nir, additional, Hoover, Paul J., additional, Aulisio, Mark, additional, Bush, William S., additional, Crawford, Dana C., additional, O'toole, John, additional, Poggio, Emilio, additional, Sedor, John, additional, Cooperman, Leslie, additional, Jolly, Stacey, additional, Herlitz, Leal, additional, Nguyen, Jane, additional, Gonzalez-Vicente, Agustin, additional, Palmer, Ellen, additional, Sendrey, Dianna, additional, Vinovskis, Carissa, additional, Bjornstad, Petter M., additional, Appelbaum, Paul, additional, Barasch, Jonathan M., additional, D'Agati, Vivette D., additional, Kiryluk, Krzysztof, additional, Mehl, Karla, additional, Canetta, Pietro A., additional, Shang, Ning, additional, Balderes, Olivia, additional, Kudose, Satoru, additional, Bansal, Shweta, additional, Alexandrov, Theodore, additional, Rennke, Helmut, additional, El-Achkar, Tarek M., additional, Cheng, Yinghua, additional, Dagher, Pierre C., additional, Eadon, Michael T., additional, Dunn, Kenneth W., additional, Kelly, Katherine J., additional, Sutton, Timothy A., additional, Barwinska, Daria, additional, Ferkowicz, Michael J., additional, Winfree, Seth, additional, Bledsoe, Sharon, additional, Rivera, Marcelino, additional, Williams, James C., additional, Ferreira, Ricardo Melo, additional, Parikh, Chirag R., additional, Corona-Villalobos, Celia P., additional, Rosenberg, Avi, additional, Rosas, Sylvia E., additional, Roy, Neil, additional, Williams, Mark, additional, Azeloglu, Evren U., additional, He, Cijang, additional, Iyengar, Ravi, additional, Hansen, Jens, additional, Xiong, Yuguang, additional, Rovin, Brad, additional, Parikh, Samir, additional, Shapiro, John P., additional, Anderton, Christopher R., additional, Pasa-Tolic, Ljiljana, additional, Velickovic, Dusan, additional, Lukowski, Jessica, additional, Oliver, George, additional, Ardayfio, Joseph, additional, Bebiak, Jack, additional, Brown, Keith, additional, Campbell, Catherine E., additional, Saul, John, additional, Shpigel, Anna, additional, Koewler, Robert, additional, Campbell, Taneisha, additional, Hayashi, Lynda, additional, Jefferson, Nichole, additional, Roberts, Glenda V., additional, Pinkeney, Roy, additional, Troyanskaya, Olga, additional, Sealfon, Rachel, additional, Tuttle, Katherine R., additional, Goltsev, Yury, additional, Zhang, Kun, additional, Laszik, Zoltan G., additional, Nolan, Garry, additional, Boada, Patrick, additional, Sarwal, Minnie, additional, Sigdel, Tara, additional, Lee, Paul J., additional, Alloway, Rita R., additional, Woodle, E. Steve, additional, Ascani, Heather, additional, Balis, Ulysses G.J., additional, Hodgin, Jeffrey B., additional, Kretzler, Matthias, additional, Lienczewski, Chrysta, additional, Mariani, Laura H., additional, Menon, Rajasree, additional, Steck, Becky, additional, He, Yougqun, additional, Otto, Edgar, additional, Schaub, Jennifer, additional, Blanc, Victoria M., additional, Eddy, Sean, additional, Conser, Ninive C., additional, Luo, Jinghui, additional, Palevsky, Paul M., additional, Rosengart, Matthew, additional, Kellum, John A., additional, Hall, Daniel E., additional, Randhawa, Parmjeet, additional, Tublin, Mitchell, additional, Murugan, Raghavan, additional, Elder, Michele M., additional, Winters, James, additional, Alpers, Charles E., additional, Blank, Kristina N., additional, Carson, Jonas, additional, De Boer, Ian H., additional, Dighe, Ashveena L., additional, Himmelfarb, Jonathan, additional, Mooney, Sean D., additional, Shankland, Stuart, additional, Williams, Kayleen, additional, Park, Christopher, additional, Dowd, Frederick, additional, McClelland, Robyn L., additional, Daniel, Stephen, additional, Hoofnagle, Andrew N., additional, Wilcox, Adam, additional, Sharma, Kumar, additional, Venkatachalam, Manjeri, additional, Zhang, Guanshi, additional, Pamreddy, Annapurna, additional, Ye, Hongping, additional, Montellano, Richard, additional, Toto, Robert D., additional, Vazquez, Miguel, additional, Lee, Simon C., additional, Miller, R. Tyler, additional, Moe, Orson W., additional, Torrealba, Jose, additional, Wang, Nancy, additional, Kermani, Asra, additional, Sambandam, Kamalanathan, additional, Park, Harold, additional, Hedayati, S. Susan, additional, Lu, Christopher Y., additional, Vijayan, Anitha, additional, Gaut, Joseph P., additional, Moledina, Dennis, additional, Wilson, Francis P., additional, Ugwuowo, Ugochukwu, additional, and Arora, Tanima, additional

Published
2022
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14. Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Author

Knight, Richard, Lecker, Stewart H., Stillman, Isaac, Bogen, Steve, Beck, Laurence H., Waikar, Sushrut, McMahon, Gearoid M., Weins, Astrid, Colona, Mia R., Hacohen, Nir, Hoover, Paul J., Aulisio, Mark, Bush, William S., Crawford, Dana C., O'toole, John, Poggio, Emilio, Sedor, John, Cooperman, Leslie, Jolly, Stacey, Herlitz, Leal, Nguyen, Jane, Gonzalez-Vicente, Agustin, Palmer, Ellen, Sendrey, Dianna, Vinovskis, Carissa, Bjornstad, Petter M., Appelbaum, Paul, Barasch, Jonathan M., Bomback, Andrew S., D'Agati, Vivette D., Kiryluk, Krzysztof, Mehl, Karla, Canetta, Pietro A., Shang, Ning, Balderes, Olivia, Kudose, Satoru, Bansal, Shweta, Alexandrov, Theodore, Rennke, Helmut, El-Achkar, Tarek M., Cheng, Yinghua, Dagher, Pierre C., Eadon, Michael T., Dunn, Kenneth W., Kelly, Katherine J., Sutton, Timothy A., Barwinska, Daria, Ferkowicz, Michael J., Winfree, Seth, Bledsoe, Sharon, Rivera, Marcelino, Williams, James C., Jr., Ferreira, Ricardo Melo, Parikh, Chirag R., Corona-Villalobos, Celia P., Menez, Steven, Rosenberg, Avi, Rosas, Sylvia E., Roy, Neil, Williams, Mark, Azeloglu, Evren U., He, Cijang, Iyengar, Ravi, Hansen, Jens, Xiong, Yuguang, Rovin, Brad, Parikh, Samir, Shapiro, John P., Anderton, Christopher R., Pasa-Tolic, Ljiljana, Velickovic, Dusan, Lukowski, Jessica, Oliver, George, Ardayfio, Joseph, Bebiak, Jack, Brown, Keith, Campbell, Catherine E., Saul, John, Shpigel, Anna, Stutzke, Christy, Koewler, Robert, Campbell, Taneisha, Hayashi, Lynda, Jefferson, Nichole, Roberts, Glenda V., Pinkeney, Roy, Troyanskaya, Olga, Sealfon, Rachel, Tuttle, Katherine R., Goltsev, Yury, Zhang, Kun, Lake, Blue B., Laszik, Zoltan G., Nolan, Garry, Boada, Patrick, Sarwal, Minnie, Sigdel, Tara, Lee, Paul J., Alloway, Rita R., Woodle, E. Steve, Ascani, Heather, Balis, Ulysses G.J., Hodgin, Jeffrey B., Kretzler, Matthias, Lienczewski, Chrysta, Mariani, Laura H., Menon, Rajasree, Steck, Becky, He, Yougqun, Otto, Edgar, Schaub, Jennifer, Blanc, Victoria M., Eddy, Sean, Conser, Ninive C., Luo, Jinghui, Palevsky, Paul M., Rosengart, Matthew, Kellum, John A., Hall, Daniel E., Randhawa, Parmjeet, Tublin, Mitchell, Murugan, Raghavan, Elder, Michele M., Winters, James, Alpers, Charles E., Blank, Kristina N., Carson, Jonas, De Boer, Ian H., Dighe, Ashveena L., Himmelfarb, Jonathan, Mooney, Sean D., Shankland, Stuart, Williams, Kayleen, Park, Christopher, Dowd, Frederick, McClelland, Robyn L., Daniel, Stephen, Hoofnagle, Andrew N., Wilcox, Adam, Grewenow, Stephanie M., Sharma, Kumar, Venkatachalam, Manjeri, Zhang, Guanshi, Pamreddy, Annapurna, Ye, Hongping, Montellano, Richard, Toto, Robert D., Vazquez, Miguel, Lee, Simon C., Miller, R. Tyler, Moe, Orson W., Torrealba, Jose, Wang, Nancy, Kermani, Asra, Sambandam, Kamalanathan, Park, Harold, Hedayati, S. Susan, Lu, Christopher Y., Jain, Sanjay, Vijayan, Anitha, Gaut, Joseph P., Moledina, Dennis, Wilson, Francis P., Ugwuowo, Ugochukwu, Arora, Tanima, and D’Agati, Vivette D.

Published
2022
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15. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

Author

Schmidt, Insa M., primary, Colona, Mia R., additional, Kestenbaum, Bryan R., additional, Alexopoulos, Leonidas G., additional, Palsson, Ragnar, additional, Srivastava, Anand, additional, Liu, Jing, additional, Stillman, Isaac E., additional, Rennke, Helmut G., additional, Vaidya, Vishal S., additional, Wu, Haojia, additional, Humphreys, Benjamin D., additional, Waikar, Sushrut S., additional, Knight, Richard, additional, Lecker, Stewart H., additional, Stillman, Isaac, additional, Bogen, Steve, additional, Amodu, Afolarin A., additional, Ilori, Titlayo, additional, Maikhor, Shana, additional, Schmidt, Insa M., additional, Beck, Laurence H., additional, Henderson, Joel M., additional, Onul, Ingrid, additional, Verma, Ashish, additional, McMahon, Gearoid M., additional, Valerius, M. Todd, additional, Waikar, Sushrut, additional, Weins, Astrid, additional, Greka, Anna, additional, Hacohen, Nir, additional, Hoover, Paul J., additional, Marshall, Jamie L., additional, Aulisio, Mark, additional, Chen, Yijiang M., additional, Janowczyk, Andrew, additional, Jayapandian, Catherine, additional, Viswanathan, Vidya S., additional, Bush, William S., additional, Crawford, Dana C., additional, Madabhushi, Anant, additional, Bush, Lakeshia, additional, Cooperman, Leslie, additional, Gonzalez-Vicente, Agustin, additional, Herlitz, Leal, additional, Jolly, Stacey, additional, Nguyen, Jane, additional, O’toole, John, additional, Palmer, Ellen, additional, Poggio, Emilio, additional, Sedor, John, additional, Sendrey, Dianna, additional, Spates-Harden, Kassandra, additional, Taliercio, Jonathan, additional, Bjornstad, Petter M., additional, Pyle, Laura, additional, Vinovskis, Carissa, additional, Appelbaum, Paul, additional, Balderes, Olivia, additional, Barasch, Jonathan M., additional, Bomback, Andrew S., additional, Canetta, Pietro A., additional, D’Agati, Vivette D., additional, Kiryluk, Krzysztof, additional, Kudose, Satoru, additional, Mehl, Karla, additional, Shang, Ning, additional, Bansal, Shweta, additional, Alexandrov, Theodore, additional, Rennke, Helmut, additional, El-Achkar, Tarek M., additional, Barwinska, Daria, additional, Bledso, Sharon, additional, Borner, Katy, additional, Bueckle, Andreas, additional, Cheng, Yinghua, additional, Dagher, Pierre C., additional, Dunn, Kenneth W., additional, Eadon, Michael T., additional, Ferkowicz, Michael J., additional, Herr, Bruce W., additional, Kelly, Katherine J., additional, Ferreira, Ricardo Melo, additional, Quardokus, Ellen M., additional, Record, Elizabeth, additional, Rivera, Marcelino, additional, Su, Jing, additional, Sutton, Timothy A., additional, Williams, James C., additional, Winfree, Seth, additional, Jain, Yashvardhan, additional, Menez, Steven, additional, Parikh, Chirag R., additional, Rosenberg, Avi, additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Johansen, Camille, additional, Rosas, Sylvia E., additional, Roy, Neil, additional, Sun, Jennifer, additional, Williams, Mark, additional, Azeloglu, Evren U., additional, Hansen, Jens, additional, He, Cijang, additional, Iyengar, Ravi, additional, Xiong, Yuguang, additional, Prasad, Pottumarthi, additional, Madhavan, Sethu M., additional, Parikh, Samir, additional, Rovin, Brad, additional, Shapiro, John P., additional, Anderton, Christopher R., additional, Lukowski, Jessica, additional, Pasa-Tolic, Ljiljana, additional, Velickovic, Dusan, additional, Oliver, George (Holt), additional, Ardayfio, Joseph, additional, Bebiak, Jack, additional, Brown, Keith, additional, Campbell, Taneisha, additional, Campbell, Catherine E., additional, Hayashi, Lynda, additional, Jefferson, Nichole, additional, Roberts, Glenda V., additional, Saul, John, additional, Shpigel, Anna, additional, Stutzke, Christy, additional, Koewler, Robert, additional, Pinkeney, Roy, additional, Sealfon, Rachel, additional, Troyanskaya, Olga, additional, Wong, Aaron, additional, Tuttle, Katherine R., additional, Pollack, Ari, additional, Goltsev, Yury, additional, Ginley, Brandon, additional, Lucarelli, Nicholas, additional, Lutnick, Brendon, additional, Sarder, Pinaki, additional, Lake, Blue B., additional, Zhang, Kun, additional, Boada, Patrick, additional, Laszik, Zoltan G., additional, Nolan, Garry, additional, Anjani, Kavya, additional, Sarwal, Minnie, additional, Mukatash, Tariq, additional, Sigdel, Tara, additional, Alloway, Rita R., additional, Burg, Ashley R., additional, Lee, Paul J., additional, Rike, Adele, additional, Shi, Tiffany, additional, Woodle, E. Steve, additional, Ascani, Heather, additional, Balis, Ulysses G.J., additional, Blanc, Victoria M., additional, Conser, Ninive C., additional, Eddy, Sean, additional, Frey, Renee, additional, He, Yougqun, additional, Hodgin, Jeffrey B., additional, Kretzler, Matthias, additional, Lienczewski, Chrysta, additional, Luo, Jinghui, additional, Mariani, Laura H., additional, Menon, Rajasree, additional, Otto, Edgar, additional, Schaub, Jennifer, additional, Steck, Becky, additional, Elder, Michele M., additional, Gilliam, Matthew, additional, Hall, Daniel E., additional, Murugan, Raghavan, additional, Palevsky, Paul M., additional, Randhawa, Parmjeet, additional, Rosengart, Matthew, additional, Tublin, Mitchell, additional, Vita, Tina, additional, Winters, James, additional, Kellum, John A., additional, Alpers, Charles E., additional, Berglund, Ashley, additional, Berry, Brooke, additional, Blank, Kristina N., additional, Carson, Jonas, additional, Daniel, Stephen, additional, De Boer, Ian H., additional, Dighe, Ashveena L., additional, Dowd, Frederick, additional, Grewenow, Stephanie M., additional, Himmelfarb, Jonathan, additional, Hoofnagle, Andrew N., additional, Limonte, Christine, additional, McClelland, Robyn L., additional, Mooney, Sean D., additional, Rezaei, Kasra, additional, Shankland, Stuart, additional, Snyder, Jamie, additional, Wang, Ruikang, additional, Wilcox, Adam, additional, Williams, Kayleen, additional, Park, Christopher, additional, Montellano, Richard, additional, Pamreddy, Annapurna, additional, Sharma, Kumar, additional, Venkatachalam, Manjeri, additional, Ye, Hongping, additional, Zhang, Guanshi, additional, Basit, Mujeeb, additional, Hedayati, S. Susan, additional, Kermani, Asra, additional, Lee, Simon C., additional, Lu, Christopher Y., additional, Miller, R. Tyler, additional, Moe, Orson W., additional, Patel, Jiten, additional, Pillai, Anil, additional, Sambandam, Kamalanathan, additional, Torrealba, Jose, additional, Toto, Robert D., additional, Vazquez, Miguel, additional, Wang, Nancy, additional, Wen, Natasha, additional, Zhang, Dianbo, additional, Park, Harold, additional, Caprioli, Richard M., additional, Patterson, Nathan, additional, Sharman, Kavya, additional, Spraggins, Jeffrey M., additional, Van de Plas, Raf, additional, Basta, Jeanine, additional, Diettman, Sabine M., additional, Gaut, Joseph P., additional, Jain, Sanjay, additional, Rauchman, Michael I., additional, Vijayan, Anitha, additional, Cantley, Lloyd G., additional, Kakade, Vijaykumar R., additional, Moledina, Dennis, additional, Shaw, Melissa M., additional, Ugwuowo, Ugochukwu, additional, Wilson, Francis P., additional, and Arora, Tanima, additional

Published
2021
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16. Rationale and design of the Kidney Precision Medicine Project

Author

Knight, Richard, Lecker, Stewart, Stillman, Isaac, Waikar, Sushrut, Mcmahon, Gearoid, Weins, Astrid, Short, Samuel, Hacohen, Nir, Hoover, Paul, Aulisio, Mark, Cooperman, Leslie, Herlitz, Leal, O’Toole, John, Poggio, Emilio, Sedor, John, Jolly, Stacey, Appelbaum, Paul, Balderes, Olivia, Barasch, Jonathan, Bomback, Andrew, Canetta, Pietro A., d’Agati, Vivette D., Kiryluk, Krzysztof, Kudose, Satoru, Mehl, Karla, Radhakrishnan, Jai, Weng, Chenhua, Barisoni, Laura, Alexandrov, Theodore, Ashkar, Tarek, Barwinska, Daria, Dagher, Pierre, Dunn, Kenneth, Eadon, Michael, Ferkowicz, Michael, Kelly, Katherine, Sutton, Timothy, Winfree, Seth, Menez, Steven, Parikh, Chirag, Rosenberg, Avi, Villalobos, Pam, Malik, Rubab, Fine, Derek, Atta, Mohammed, Monroy Trujillo, Jose Manuel, Slack, Alison, Rosas, Sylvia, Williams, Mark, Azeloglu, Evren, He, Cijang (John), Iyengar, Ravi, Hansen, Jens, Parikh, Samir, Rovin, Brad, Anderton, Chris, Pasa-Tolic, Ljiljana, Velickovic, Dusan, Lukowski, Jessica, Oliver, George (Holt), Ardayfio, Joseph, Bebiak, Jack, Brown, Keith, Campbell, Taneisha, Campbell, Catherine, Hayashi, Lynda, Jefferson, Nichole, Koewler, Robert, Roberts, Glenda, Saul, John, Shpigel, Anna, Stutzke, Edith Christine, Wright, Lorenda, Miegs, Leslie, Pinkeney, Roy, Sealfon, Rachel, Troyanskaya, Olga, Tuttle, Katherine, Dobi, Dejan, Goltsev, Yury, Lake, Blue, Zhang, Kun, Joanes, Maria, Laszik, Zoltan, Schroeder, Andrew, Sarwal, Minnie, Sigdel, Tara, Balis, Ulysses, Blanc, Victoria, He, Oliver, Hodgin, Jeffrey, Kretzler, Matthias, Mariani, Laura, Menon, Rajasree, Otto, Edgar, Schaub, Jennifer, Steck, Becky, Lienczewski, Chrysta, Eddy, Sean, Elder, Michele, Hall, Daniel, Kellum, John, Kruth, Mary, Murugan, Raghav, Palevsky, Paul, Randhawa, Parmjeet, Rosengart, Matthew, Sims-Lucas, Sunny, Stefanick, Mary, Stull, Stacy, Tublin, Mitchell, Alpers, Charles, de Boer, Ian, Dighe, Ashveena, Himmelfarb, Jonathan, Mcclelland, Robyn, Mooney, Sean, Shankland, Stuart, Williams, Kayleen, Blank, Kristina, Carson, Jonas, Dowd, Frederick, Drager, Zach, Park, Christopher, Sharma, Kumar, Zhang, Guanshi, Bansal, Shweta, Venkatachalam, Manjeri, Kermani, Asra, Lee, Simon, Lu, Christopher, Miller, Tyler, Moe, Orson, Park, Harold, Sambandam, Kamalanathan, Sanchez, Francisco, Torrealba, Jose, Robert, Toto, Vazquez, Miguel, Wang, Nancy, Gaut, Joe, Jain, Sanjay, Vijayan, Anitha, Luciano, Randy, Moledina, Dennis, Ugochukwu, Ugwuowo, Wilson, Francis Perry, Alfano, Sandy, de Boer, Ian H., Alpers, Charles E., Azeloglu, Evren U., Balis, Ulysses G.J., Barasch, Jonathan M., Blank, Kristina N., Bomback, Andrew S., Dagher, Pierre C., Dighe, Ashveena L., Eadon, Michael T., El-Achkar, Tarek M., Gaut, Joseph P., He, Yongqun, Hodgin, Jeffrey B., Kellum, John A., Laszik, Zoltan G., Mariani, Laura H., McClelland, Robyn L., Moledina, Dennis G., Mooney, Sean D., O’Toole, John F., Palevsky, Paul M., Parikh, Chirag R., Poggio, Emilio D., Rosas, Sylvia E., Rosengart, Matthew R., Sarwal, Minnie M., Schaub, Jennifer A., Sedor, John R., Toto, Robert D., Troyanskaya, Olga G., Tuttle, Katherine R., Vazquez, Miguel A., and Waikar, Sushrut S.

Published
2021
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22. The authors reply

Author

Hall, Isaac E., primary, Jia, Yaqi, additional, Thiessen-Philbrook, Heather R., additional, Greene, Tom, additional, Parikh, Chirag R., additional, Akalin, Enver, additional, Bromberg, Jonathan S., additional, Doshi, Mona D., additional, Harhay, Meera N., additional, Hall, Isaac E., additional, Mansour, Sherry G., additional, Mohan, Sumit, additional, Muthukumar, Thangamani, additional, Reese, Peter P., additional, Schröppel, Bernd, additional, Singh, Pooja, additional, and Weng, Francis L., additional

Published
2019
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24. Deceased-donor acute kidney injury is not associated with kidney allograft failure

Author

Hall, Isaac E., primary, Akalin, Enver, additional, Bromberg, Jonathan S., additional, Doshi, Mona D., additional, Greene, Tom, additional, Harhay, Meera N., additional, Jia, Yaqi, additional, Mansour, Sherry G., additional, Mohan, Sumit, additional, Muthukumar, Thangamani, additional, Reese, Peter P., additional, Schröppel, Bernd, additional, Singh, Pooja, additional, Thiessen-Philbrook, Heather R., additional, Weng, Francis L., additional, and Parikh, Chirag R., additional

Published
2019
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30. Oral bisphosphonate use in the elderly is not associated with acute kidney injury

Author

Shih, Andrew W.Y., primary, Weir, Matthew A., additional, Clemens, Kristin K., additional, Yao, Zhan, additional, Gomes, Tara, additional, Mamdani, Muhammad M., additional, Juurlink, David N., additional, Hird, Amanda, additional, Hodsman, Anthony, additional, Parikh, Chirag R., additional, Wald, Ron, additional, Cadarette, Suzanne M., additional, and Garg, Amit X., additional

Published
2012
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34. Early postoperative serum cystatin C predicts severe acute kidney injury following pediatric cardiac surgery

Author

Zappitelli, Michael, primary, Krawczeski, Catherine D., additional, Devarajan, Prasad, additional, Wang, Zhu, additional, Sint, Kyaw, additional, Thiessen-Philbrook, Heather, additional, Li, Simon, additional, Bennett, Michael R., additional, Ma, Qing, additional, Shlipak, Michael G., additional, Garg, Amit X., additional, and Parikh, Chirag R., additional

Published
2011
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39. A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death

Author

Ikizler, T. Alp, Parikh, Chirag R., Himmelfarb, Jonathan, Chinchilli, Vernon M., Liu, Kathleen D., Coca, Steven G., Garg, Amit X., Hsu, Chi-yuan, Siew, Edward D., Wurfel, Mark M., Ware, Lorraine B., Faulkner, Georgia Brown, Tan, Thida C., Kaufman, James S., Kimmel, Paul L., Go, Alan S., Chinchilli, Vernon M., Go, Alan S., Himmelfarb, Jonathan, Ikizler, T. Alp, Kaufman, James S., Kimmel, Paul L., Parikh, Chirag R., Stokes, John B., Coca, Steven, Garg, Amit, Zheng, Sijie, Pravoverov, Leonid, Hsu, Chi-yuan, Hsu, Raymond K., Liu, Kathleen D., Reeves, W. Brian, Siew, Edward D., Lewis, Julia B., Ware, Lorraine, Devarajan, Prasad, Krawczeski, Catherine, Bennett, Michael, Zappitelli, Michael, and Wurfel, Mark

Abstract

Acute kidney injury (AKI) has been reported to be associated with excess risks of death, kidney disease progression and cardiovascular events although previous studies have important limitations. To further examine this, we prospectively studied adults from four clinical centers surviving three months and more after hospitalization with or without AKI who were matched on center, pre-admission CKD status, and an integrated priority score based on age, prior cardiovascular disease or diabetes mellitus, preadmission estimated glomerular filtration rate (eGFR) and treatment in the intensive care unit during the index hospitalization between December 2009-February 2015, with follow-up through November 2018. All participants had assessments of kidney function before (eGFR) and at three months and annually (eGFR and proteinuria) after the index hospitalization. Associations of AKI with outcomes were examined after accounting for pre-admission and three-month post-discharge factors. Among 769 AKI (73% Stage 1, 14% Stage 2, 13% Stage 3) and 769 matched non-AKI adults, AKI was associated with higher adjusted rates of incident CKD (adjusted hazard ratio 3.98, 95% confidence interval 2.51-6.31), CKD progression (2.37,1.28-4.39), heart failure events (1.68, 1.22-2.31) and all-cause death (1.78, 1.24-2.56). AKI was not associated with major atherosclerotic cardiovascular events in multivariable analysis (0.95, 0.70-1.28). After accounting for degree of kidney function recovery and proteinuria at three months after discharge, the associations of AKI with heart failure (1.13, 0.80-1.61) and death (1.29, 0.84-1.98) were attenuated and no longer significant. Thus, assessing kidney function recovery and proteinuria status three months after AKI provides important prognostic information for long-term clinical outcomes.

Published
2020
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40. Untargeted metabolomics of perfusate and their Association with pump perfusion and allograft failure

Author

Liu, Richard X., Koyawala, Neel, Thiessen-Philbrook, Heather R., Doshi, Mona D., Reese, Peter P., Hall, Isaac E., Mohan, Sumit, and Parikh, Chirag R.

Abstract

Although hypothermic machine perfusion (HMP) is associated with improved kidney graft viability and function, the underlying biological mechanisms are unknown. Untargeted metabolomic profiling may identify potential metabolites and pathways that can help assess allograft viability and contribute to organ preservation. Therefore, in this multicenter study, we measured all detectable metabolites in perfusate collected at the beginning and end of deceased-donor kidney perfusion and evaluated their associations with graft failure. In our cohort of 190 kidney transplants, 33 (17%) had death-censored graft failure over a median follow-up of 5.0 years (IQR 3.0-6.1 years). We identified 553 known metabolites in perfusate and characterized their experimental and biological consistency through duplicate samples and unsupervised clustering. After perfusion-time adjustment and false discovery correction, six metabolites in post-HMP perfusate were significantly associated with death-censored graft failure, including alpha-ketoglutarate, 3-carboxy-4-methyl-5-propyl-2-furanpropanoate, 1-carboxyethylphenylalanine, and three glycerol-phosphatidylcholines. All six metabolites were associated with an increased risk of graft failure (Hazard Ratio per median absolute deviation range 1.04-1.45). Four of six metabolites also demonstrated significant interaction with donation after cardiac death with notably greater risk in the donation after cardiac death group (Hazard Ratios up to 1.69). Discarded kidneys did not have significantly different levels of any death-censored graft failure-associated metabolites. On interrogation of pathway analysis, production of reactive oxygen species and increased metabolism of fatty acids were upregulated in kidneys that subsequently developed death-censored graft failure. Thus, further understanding the role of these metabolites may inform the HMP process and help improve the objective evaluation of allograft offers, thereby reducing the discard of potentially viable organs.

Published
2022
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