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11 results on '"Hsu, Stephen"'

1. Evidence from the Oxford Classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy

Author

Alpers, Charles E., Amore, Alessandro, Barratt, Jonathan, Berthoux, Francois, Bonsib, Stephen, Bruijn, Jan A., Cattran, Daniel C., Coppo, Rosanna, D'Agati, Vivette, D'Amico, Giuseppe, Emancipator, Steven, Emma, Francesco, Feehally, John, Ferrario, Franco, Fervenza, Fernando C., Florquin, Sandrine, Fogo, Agnes, Geddes, Colin C., Groene, Hermann-Josef, Haas, Mark, Herzenberg, Andrew M., Hill, Prue A., Hogg, Ronald J., Hsu, Stephen I., Jennette, J. Charles, Joh, Kensuke, Julian, Bruce A., Kawamura, Tetsuya, Lai, Fernand M., Li, Lei-Shi, Li, Philip K.T., Liu, Zhi-Hong, Mackinnon, Bruce, Mezzano, Sergio, Schena, F. Paolo, Tomino, Yasuhiko, Walker, Patrick D., Wang, Haiyan, Weening, Jan J., Yoshikawa, Nori, Zhang, Hong, Bellur, Shubha S., Lepeytre, Fanny, Vorobyeva, Olga, Troyanov, Stéphan, Cook, H. Terence, and Roberts, Ian S.D.

Published
2017
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2. The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults

Author

Coppo, Rosanna, Troyanov, Stéphan, Camilla, Roberta, Hogg, Ronald J., Cattran, Daniel C., Terence Cook, H., Feehally, John, Roberts, Ian S.D., Amore, Alessandro, Alpers, Charles E., Barratt, Jonathan, Berthoux, Francois, Bonsib, Stephen, Bruijn, Jan A., D'Agati, Vivette, D'Amico, Giuseppe, Emancipator, Steven N., Emma, Francesco, Ferrario, Franco, Fervenza, Fernando C., Florquin, Sandrine, Fogo, Agnes B., Geddes, Colin C., Groene, Hermann J., Haas, Mark, Herzenberg, Andrew M., Hill, Prue A., Hsu, Stephen I., Charles Jennette, J., Joh, Kensuke, Julian, Bruce A., Kawamura, Tetsuya, Lai, Fernand M., Li, Lei S., Li, Philip K., Liu, Zhi H., Mezzano, Sergio, Paolo Schena, F., Tomino, Yasuhiko, Walker, Patrick D., Wang, Haiyan, Weening, Jan J., Yoshikawa, Norishige, and Zhang, Hong

Published
2010
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3. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification

Author

A Working Group of the International IgA Nephropathy Network and the Renal Pathology Society, Cattran, Daniel C., Coppo, Rosanna, Cook, H. Terence, Feehally, John, Roberts, Ian S.D., Troyanov, Stéphan, Alpers, Charles E., Amore, Alessandro, Barratt, Jonathan, Berthoux, Francois, Bonsib, Stephen, Bruijn, Jan A., D'Agati, Vivette, D'Amico, Giuseppe, Emancipator, Steven, Emma, Francesco, Ferrario, Franco, Fervenza, Fernando C., Florquin, Sandrine, Fogo, Agnes, Geddes, Colin C., Groene, Hermann-Josef, Haas, Mark, Herzenberg, Andrew M., Hill, Prue A., Hogg, Ronald J., Hsu, Stephen I., Jennette, J. Charles, Joh, Kensuke, Julian, Bruce A., Kawamura, Tetsuya, Lai, Fernand M., Leung, Chi Bon, Li, Lei-Shi, Li, Philip K.T., Liu, Zhi-Hong, Mackinnon, Bruce, Mezzano, Sergio, Schena, F. Paolo, Tomino, Yasuhiko, Walker, Patrick D., Wang, Haiyan, Weening, Jan J., Yoshikawa, Nori, and Zhang, Hong

Published
2009
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4. The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility

Author

A Working Group of the International IgA Nephropathy Network and the Renal Pathology Society, Roberts, Ian S.D., Cook, H. Terence, Troyanov, Stéphan, Alpers, Charles E., Amore, Alessandro, Barratt, Jonathan, Berthoux, Francois, Bonsib, Stephen, Bruijn, Jan A., Cattran, Daniel C., Coppo, Rosanna, D'Agati, Vivette, D'Amico, Giuseppe, Emancipator, Steven, Emma, Francesco, Feehally, John, Ferrario, Franco, Fervenza, Fernando C., Florquin, Sandrine, Fogo, Agnes, Geddes, Colin C., Groene, Hermann-Josef, Haas, Mark, Herzenberg, Andrew M., Hill, Prue A., Hogg, Ronald J., Hsu, Stephen I., Jennette, J. Charles, Joh, Kensuke, Julian, Bruce A., Kawamura, Tetsuya, Lai, Fernand M., Li, Lei-Shi, Li, Philip K.T., Liu, Zhi-Hong, Mackinnon, Bruce, Mezzano, Sergio, Schena, F. Paolo, Tomino, Yasuhiko, Walker, Patrick D., Wang, Haiyan, Weening, Jan J., Yoshikawa, Nori, and Zhang, Hong

Published
2009
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9. Evidence from the Oxford Classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy

Author

Bellur, Shubha S., primary, Lepeytre, Fanny, additional, Vorobyeva, Olga, additional, Troyanov, Stéphan, additional, Cook, H. Terence, additional, Roberts, Ian S.D., additional, Alpers, Charles E., additional, Amore, Alessandro, additional, Barratt, Jonathan, additional, Berthoux, Francois, additional, Bonsib, Stephen, additional, Bruijn, Jan A., additional, Cattran, Daniel C., additional, Coppo, Rosanna, additional, D'Agati, Vivette, additional, D'Amico, Giuseppe, additional, Emancipator, Steven, additional, Emma, Francesco, additional, Feehally, John, additional, Ferrario, Franco, additional, Fervenza, Fernando C., additional, Florquin, Sandrine, additional, Fogo, Agnes, additional, Geddes, Colin C., additional, Groene, Hermann-Josef, additional, Haas, Mark, additional, Herzenberg, Andrew M., additional, Hill, Prue A., additional, Hogg, Ronald J., additional, Hsu, Stephen I., additional, Jennette, J. Charles, additional, Joh, Kensuke, additional, Julian, Bruce A., additional, Kawamura, Tetsuya, additional, Lai, Fernand M., additional, Li, Lei-Shi, additional, Li, Philip K.T., additional, Liu, Zhi-Hong, additional, Mackinnon, Bruce, additional, Mezzano, Sergio, additional, Schena, F. Paolo, additional, Tomino, Yasuhiko, additional, Walker, Patrick D., additional, Wang, Haiyan, additional, Weening, Jan J., additional, Yoshikawa, Nori, additional, and Zhang, Hong, additional

Published
2017
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10. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification.

Author

Cattran DC, Coppo R, Cook HT, Feehally J, Roberts IS, Troyanov S, Alpers CE, Amore A, Barratt J, Berthoux F, Bonsib S, Bruijn JA, D'Agati V, D'Amico G, Emancipator S, Emma F, Ferrario F, Fervenza FC, Florquin S, Fogo A, Geddes CC, Groene HJ, Haas M, Herzenberg AM, Hill PA, Hogg RJ, Hsu SI, Jennette JC, Joh K, Julian BA, Kawamura T, Lai FM, Leung CB, Li LS, Li PK, Liu ZH, Mackinnon B, Mezzano S, Schena FP, Tomino Y, Walker PD, Wang H, Weening JJ, Yoshikawa N, and Zhang H

Subjects
Adolescent, Adult, Aged, Biopsy, Child, Child, Preschool, Female, Glomerular Filtration Rate, Glomerulonephritis, IGA ethnology, Glomerulonephritis, IGA physiopathology, Humans, Kidney Glomerulus pathology, Male, Middle Aged, Glomerulonephritis, IGA classification, Glomerulonephritis, IGA pathology, Kidney pathology
Abstract

IgA nephropathy is the most common glomerular disease worldwide, yet there is no international consensus for its pathological or clinical classification. Here a new classification for IgA nephropathy is presented by an international consensus working group. The goal of this new system was to identify specific pathological features that more accurately predict risk of progression of renal disease in IgA nephropathy, thus enabling both clinicians and pathologists to improve individual patient prognostication. In a retrospective analysis, sequential clinical data were obtained on 265 adults and children with IgA nephropathy who were followed for a median of 5 years. Renal biopsies from all patients were scored by pathologists blinded to the clinical data for pathological variables identified as reproducible by an iterative process. Four of these variables: (1) the mesangial hypercellularity score, (2) segmental glomerulosclerosis, (3) endocapillary hypercellularity, and (4) tubular atrophy/interstitial fibrosis were subsequently shown to have independent value in predicting renal outcome. These specific pathological features withstood rigorous statistical analysis even after taking into account all clinical indicators available at the time of biopsy as well as during follow-up. The features have prognostic significance and we recommended they be taken into account for predicting outcome independent of the clinical features both at the time of presentation and during follow-up. The value of crescents was not addressed due to their low prevalence in the enrolled cohort.

Published
2009
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11. The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility.

Author

Roberts IS, Cook HT, Troyanov S, Alpers CE, Amore A, Barratt J, Berthoux F, Bonsib S, Bruijn JA, Cattran DC, Coppo R, D'Agati V, D'Amico G, Emancipator S, Emma F, Feehally J, Ferrario F, Fervenza FC, Florquin S, Fogo A, Geddes CC, Groene HJ, Haas M, Herzenberg AM, Hill PA, Hogg RJ, Hsu SI, Jennette JC, Joh K, Julian BA, Kawamura T, Lai FM, Li LS, Li PK, Liu ZH, Mackinnon B, Mezzano S, Schena FP, Tomino Y, Walker PD, Wang H, Weening JJ, Yoshikawa N, and Zhang H

Subjects
Biopsy, Humans, Mesangial Cells pathology, Necrosis, Reproducibility of Results, Glomerulonephritis, IGA classification, Glomerulonephritis, IGA pathology, Kidney pathology
Abstract

Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glomerular disease, IgA nephropathy, in which renal pathologists first undertook extensive iterative work to define pathologic variables with acceptable inter-observer reproducibility. Where groups of such features closely correlated, variables were further selected on the basis of least susceptibility to sampling error and ease of scoring in routine practice. This process identified six pathologic variables that could then be used to interrogate prognostic significance independent of the clinical data in IgA nephropathy (described in the accompanying article). These variables were (1) mesangial cellularity score; percentage of glomeruli showing (2) segmental sclerosis, (3) endocapillary hypercellularity, or (4) cellular/fibrocellular crescents; (5) percentage of interstitial fibrosis/tubular atrophy; and finally (6) arteriosclerosis score. Results for interobserver reproducibility of individual pathological features are likely applicable to other glomerulonephritides, but it is not known if the correlations between variables depend on the specific type of glomerular pathobiology. Variables identified in this study withstood rigorous pathology review and statistical testing and we recommend that they become a necessary part of pathology reports for IgA nephropathy. Our methodology, translating a strong evidence-based dataset into a working format, is a model for developing classifications of other types of renal disease.

Published
2009
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