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Your search keyword '"Castrop, Hayo"' showing total 1 results
Start Over Author "Castrop, Hayo" Topic erythropoietin Journal kidney international
1 results on '"Castrop, Hayo"'

1. Functional evidence confirmed by histological localization: overlapping expression of erythropoietin and HIF-2alpha in interstitial fibroblasts of the renal cortex.

Author

Castrop H and Kurtz A

Subjects
Animals, Basic Helix-Loop-Helix Transcription Factors biosynthesis, Erythropoietin biosynthesis, Fibroblasts metabolism, Kidney cytology, Kidney metabolism
Abstract

Erythropoietin (EPO) is the central hormone in the regulation of erythropoiesis. Synthesis of EPO and its constitutive release into the circulation are controlled by the transcriptional activity of the EPO gene. A key regulator of EPO is the dimeric hypoxia-inducible transcription factor (HIF), which has three isoforms. Paliege and co-workers provide convincing morphological evidence that it is the HIF-2 isoform that essentially triggers EPO in the kidney, which is the primary source of EPO in the body.

Published
2010
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